Inflammatory Bowel Disease as a Model for Translating the Microbiome
The inflammatory bowel diseases (IBDs) are among the most closely studied chronic inflammatory disorders that involve environmental, host genetic, and commensal microbial factors. This combination of features has made IBD both an appropriate and a high-priority platform for translatable research in...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2014-06, Vol.40 (6), p.843-854 |
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| creator | Huttenhower, Curtis Kostic, Aleksandar D. Xavier, Ramnik J. |
| description | The inflammatory bowel diseases (IBDs) are among the most closely studied chronic inflammatory disorders that involve environmental, host genetic, and commensal microbial factors. This combination of features has made IBD both an appropriate and a high-priority platform for translatable research in host-microbiome interactions. Decades of epidemiology have identified environmental risk factors, although most mechanisms of action remain unexplained. The genetic architecture of IBD has been carefully dissected in multiple large populations, identifying several responsible host epithelial and immune pathways but without yet a complete systems-level explanation. Most recently, the commensal gut microbiota have been found to be both ecologically and functionally perturbed during the disease, but with as-yet-unexplained heterogeneity among IBD subtypes and individual patients. IBD thus represents perhaps the most comprehensive current model for understanding the human microbiome’s role in complex inflammatory disease. Here, we review the influences of the microbiota on IBD and its potential for translational medicine.
Inflammatory bowel diseases (IBDs) involve environmental, host genetic, and commensal microbial factors, thereby allowing interrogation of interactions between the microbiome and immune system. Here Huttenhower et al. review the role of microbiota in IBD and its potential for translational medicine. |
| doi_str_mv | 10.1016/j.immuni.2014.05.013 |
| format | Article |
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Inflammatory bowel diseases (IBDs) involve environmental, host genetic, and commensal microbial factors, thereby allowing interrogation of interactions between the microbiome and immune system. Here Huttenhower et al. review the role of microbiota in IBD and its potential for translational medicine.</description><subject>Animals</subject><subject>Antibiotics</subject><subject>Biogeography</subject><subject>Colitis, Ulcerative - immunology</subject><subject>Colitis, Ulcerative - microbiology</subject><subject>Crohn Disease - immunology</subject><subject>Crohn Disease - microbiology</subject><subject>Disease Models, Animal</subject><subject>Gastrointestinal Tract - immunology</subject><subject>Gastrointestinal Tract - microbiology</subject><subject>Genomes</subject><subject>Humans</subject><subject>Inflammatory bowel disease</subject><subject>Metabolites</subject><subject>Metagenome</subject><subject>Mice</subject><subject>Microbiota - immunology</subject><subject>Pathogenesis</subject><subject>Translational Medical Research</subject><issn>1074-7613</issn><issn>1097-4180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF9PwjAUxRujEUS_gTFLfN5s13bdXkwU_EMC8QWfm667g5JtxXZo-PYOQdQX-3Kbe0_P_fUgdElwRDBJbpaRqet1Y6IYExZhHmFCj1Cf4EyEjKT4eHsXLBQJoT105v0Sd0Ke4VPUi1nGcYxZH43GTVmpulatdZvg3n5AFYyMB-UhUD5QwdQWXau0Lpg51fhKtaaZB-0CgqnRzubG1nCOTkpVebjY1wF6fXyYDZ_DycvTeHg3CTXnog0F04XgLM1ZDh1BrFjCBImz7pR5meiUaprglMcgkpyURQYpphCXhKqEcULpAN3ufFfrvIZCQ9M6VcmVM7VyG2mVkX8njVnIuX2XjFDO2Nbgem_g7NsafCuXdu2ajlkSTkXK4iwlnYrtVN3_vHdQHjYQLLfZy6XcZS-32UvMJf6iu_pNd3j0HfYPPnQZvRtw0msDjYbCONCtLKz5f8MnNueWtg</recordid><startdate>20140619</startdate><enddate>20140619</enddate><creator>Huttenhower, Curtis</creator><creator>Kostic, Aleksandar D.</creator><creator>Xavier, Ramnik J.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20140619</creationdate><title>Inflammatory Bowel Disease as a Model for Translating the Microbiome</title><author>Huttenhower, Curtis ; 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Inflammatory bowel diseases (IBDs) involve environmental, host genetic, and commensal microbial factors, thereby allowing interrogation of interactions between the microbiome and immune system. Here Huttenhower et al. review the role of microbiota in IBD and its potential for translational medicine.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24950204</pmid><doi>10.1016/j.immuni.2014.05.013</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antibiotics Biogeography Colitis, Ulcerative - immunology Colitis, Ulcerative - microbiology Crohn Disease - immunology Crohn Disease - microbiology Disease Models, Animal Gastrointestinal Tract - immunology Gastrointestinal Tract - microbiology Genomes Humans Inflammatory bowel disease Metabolites Metagenome Mice Microbiota - immunology Pathogenesis Translational Medical Research |
| title | Inflammatory Bowel Disease as a Model for Translating the Microbiome |
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