Thrombospondin related anonymous protein (TRAP) of Plasmodium falciparum binds specifically to sulfated glycoconjugates and to HepG2 hepatoma cells suggesting a role for this molecule in sporozoite invasion of hepatocytes

Thrombospondin related anonymous protein (TRAP) of Plasmodium falciparum contains an amino acid motif based around the sequence WSPCSVTCG which is also found in region II of the circumsporozoite (CS) proteins of different species of Plasmodium. This amino acid motif confers on the CS protein the abi...

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Veröffentlicht in:	The EMBO journal 1993-07, Vol.12 (7), p.2881-2889
Hauptverfasser:	Müller, H.M., Reckmann, I., Hollingdale, M.R., Bujard, H., Robson, K.J., Crisanti, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Binding Sites Biological and medical sciences Carcinoma, Hepatocellular Cloning, Molecular DNA, Single-Stranded Escherichia coli Fundamental and applied biological sciences. Psychology Glycoconjugates - chemistry Glycoconjugates - metabolism Life cycle. Host-agent relationship. Pathogenesis Liver - parasitology Molecular Sequence Data Plasmodium falciparum Plasmodium falciparum - metabolism Plasmodium falciparum - physiology Platelet Membrane Glycoproteins - genetics Platelet Membrane Glycoproteins - metabolism Protozoa Protozoan Proteins - chemistry Protozoan Proteins - genetics Protozoan Proteins - metabolism Sulfuric Acids - chemistry Thrombospondins Tumor Cells, Cultured
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