AEG-1 Regulates Retinoid X Receptor and Inhibits Retinoid Signaling

Retinoid X receptor (RXR) regulates key cellular responses such as cell growth and development, and this regulation is frequently perturbed in various malignancies, including hepatocellular carcinoma (HCC). However, the molecule(s) that physically govern this deregulation are mostly unknown. Here, w...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2014-08, Vol.74 (16), p.4364-4377
Hauptverfasser:	SRIVASTAVA, Jyoti, ROBERTSON, Chadia L, SHAH, Khalid, BHERE, Deepak, SUBLER, Mark A, WINDLE, Jolene J, FISHER, Paul B, SARKAR, Devanand, RAJASEKARAN, Devaraja, GREDLER, Rachel, SIDDIQ, Ayesha, EMDAD, Luni, MUKHOPADHYAY, Nitai D, GHOSH, Shobha, HYLEMON, Phillip B, GIL, Gregorio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cell Adhesion Molecules - antagonists & inhibitors Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell Differentiation - physiology Gene Knockdown Techniques HEK293 Cells Heterografts Humans Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Medical sciences Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Nude Mice, Transgenic Pharmacology. Drug treatments Phosphorylation Promoter Regions, Genetic Retinoid X Receptors - antagonists & inhibitors Retinoid X Receptors - genetics Retinoid X Receptors - metabolism Retinoids - antagonists & inhibitors Retinoids - metabolism Signal Transduction Transfection Tretinoin - pharmacology Tumors Up-Regulation
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