Targeted expression of a dominant‐negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation

In this study we used a dominant‐negative FGF receptor mutant to block FGF function in a specific tissue of transgenic mice. The mutant receptor, which is known to block signal transduction in cells when co‐expressed with wild‐type receptors, was targeted to suprabasal keratinocytes using a keratin...

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