Metabolic syndrome impairs notch signaling and promotes apoptosis in chronically ischemic myocardium

Objective Impaired angiogenesis is a known consequence of metabolic syndrome (MetS); however, the mechanism is not fully understood. Recent studies have shown that the notch signaling pathway is an integral component of cardiac angiogenesis. We tested, in a clinically relevant swine model, the effec...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of thoracic and cardiovascular surgery 2014-09, Vol.148 (3), p.1048-1055
Hauptverfasser:	Elmadhun, Nassrene Y., MD, Sabe, Ashraf A., MD, Lassaletta, Antonio D., MD, Chu, Louis M., MD, Kondra, Katelyn, BS, Sturek, Michael, PhD, Sellke, Frank W., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenic Proteins - metabolism Animals Apoptosis Apoptosis Regulatory Proteins - metabolism Cardiothoracic Surgery Chronic Disease Disease Models, Animal Male Metabolic Syndrome - complications Metabolic Syndrome - metabolism Metabolic Syndrome - pathology Metabolic Syndrome - physiopathology Myocardial Ischemia - complications Myocardial Ischemia - metabolism Myocardial Ischemia - pathology Myocardial Ischemia - physiopathology Myocardium - metabolism Myocardium - pathology Neovascularization, Physiologic Receptors, Notch - metabolism Signal Transduction Swine Swine, Miniature Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!