Weight as Predictors of Clinical Progression and Treatment Failure: Results From the TREAT Asia Pediatric HIV Observational Database

OBJECTIVE:To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART). METHODS:We used Cox regression to analyze data of a cohort of Asian children. RESULTS:A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score < −3 was associated with mortality (P < 0.001) independent of CD4% and < −2 was associated with immunological failure (P ≤ 0.03) independent of age at cART. CONCLUSIONS:Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings.