Protein Biomarker Identification in the CSF of Patients With CNS Lymphoma

Elucidation of the CSF proteome may yield insights into the pathogenesis of CNS disease. We tested the hypothesis that individual CSF proteins distinguish CNS lymphoma from benign focal brain lesions. We used a liquid chromatography/mass spectrometry-based method to differentially quantify and ident...

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Veröffentlicht in:	Journal of clinical oncology 2008-01, Vol.26 (1), p.96-105
Hauptverfasser:	ROY, Sushmita, JOSEPHSON, S. Andrew, JONES, Ted, BECKER, Christopher H, SCHULMAN, Howard, RUBENSTEIN, James L, FRIDLYAND, Jane, KARCH, Jon, KADOCH, Cigall, KARRIM, Juliana, DAMON, Lloyd, TRESELER, Patrick, KUNWAR, Sandeep, SHUMAN, Marc A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antithrombin III - genetics Antithrombin III - metabolism Biological and medical sciences Biomarkers, Tumor - cerebrospinal fluid Brain Neoplasms - cerebrospinal fluid Brain Neoplasms - pathology Case-Control Studies Chromatography, Liquid Diagnosis, Differential Enzyme-Linked Immunosorbent Assay Female Hematologic and hematopoietic diseases Humans Immunoblotting Immunoenzyme Techniques Leukemia, Myeloid - cerebrospinal fluid Leukemia, Myeloid - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma - cerebrospinal fluid Lymphoma - pathology Lymphoma, B-Cell - cerebrospinal fluid Lymphoma, B-Cell - pathology Lymphoma, B-Cell, Marginal Zone - cerebrospinal fluid Lymphoma, B-Cell, Marginal Zone - pathology Lymphoma, Large B-Cell, Diffuse - cerebrospinal fluid Lymphoma, Large B-Cell, Diffuse - pathology Lymphoma, Non-Hodgkin - cerebrospinal fluid Lymphoma, Non-Hodgkin - pathology Male Medical sciences Middle Aged Neoplasm Proteins - cerebrospinal fluid Proteomics Sensitivity and Specificity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Survival Rate Tumors
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