Speckle contrast optical spectroscopy, a non-invasive, diffuse optical method for measuring microvascular blood flow in tissue

Speckle contrast optical spectroscopy, a non-invasive, diffuse optical method for measuring microvascular blood flow in tissue

We introduce a new, non-invasive, diffuse optical technique, speckle contrast optical spectroscopy (SCOS), for probing deep tissue blood flow using the statistical properties of laser speckle contrast and the photon diffusion model for a point source. The feasibility of the method is tested using li...

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Veröffentlicht in:Biomedical optics express 2014-08, Vol.5 (8), p.2769-2784
Hauptverfasser: Valdes, Claudia P, Varma, Hari M, Kristoffersen, Anna K, Dragojevic, Tanja, Culver, Joseph P, Durduran, Turgut
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container_end_page 2784
container_issue 8
container_start_page 2769
container_title Biomedical optics express
container_volume 5
creator Valdes, Claudia P
Varma, Hari M
Kristoffersen, Anna K
Dragojevic, Tanja
Culver, Joseph P
Durduran, Turgut
description We introduce a new, non-invasive, diffuse optical technique, speckle contrast optical spectroscopy (SCOS), for probing deep tissue blood flow using the statistical properties of laser speckle contrast and the photon diffusion model for a point source. The feasibility of the method is tested using liquid phantoms which demonstrate that SCOS is capable of measuring the dynamic properties of turbid media non-invasively. We further present an in vivo measurement in a human forearm muscle using SCOS in two modalities: one with the dependence of the speckle contrast on the source-detector separation and another on the exposure time. In doing so, we also introduce crucial corrections to the speckle contrast that account for the variance of the shot and sensor dark noises.
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title Speckle contrast optical spectroscopy, a non-invasive, diffuse optical method for measuring microvascular blood flow in tissue
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