MDM2 Regulates Hypoxic Hypoxia-inducible Factor 1α Stability in an E3 Ligase, Proteasome, and PTEN-Phosphatidylinositol 3-Kinase-AKT-dependent Manner

Hypoxia-inducible factor 1 (HIF1) is a heterodimeric transcription factor containing an inducibly expressed HIF1α subunit and a constitutively expressed HIF1β subunit. Under hypoxic conditions, the HIF1α subunit accumulates because of a decrease in the rate of proteolytic degradation, and the result...

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Veröffentlicht in:	The Journal of biological chemistry 2014-08, Vol.289 (33), p.22785-22797
Hauptverfasser:	Joshi, Shweta, Singh, Alok R., Durden, Donald L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Hypoxia - genetics Cell Line Enzyme Inhibitors Glucose Transporter Type 1 - genetics Glucose Transporter Type 1 - metabolism Hexokinase - genetics Hexokinase - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Mice Mice, Knockout Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Protein Stability Proteolysis Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-mdm2 - genetics Proto-Oncogene Proteins c-mdm2 - metabolism PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Signal Transduction
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