Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons

Rapid input-restricted change in gene expression is an important aspect of synaptic plasticity requiring complex mechanisms of post-transcriptional mRNA trafficking and regulation. Small non-coding miRNA are uniquely poised to support these functions by providing a nucleic-acid-based specificity com...

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Veröffentlicht in:	Nucleic acids research 2014-08, Vol.42 (14), p.9195-9208
Hauptverfasser:	Goldie, Belinda J, Dun, Matthew D, Lin, Minjie, Smith, Nathan D, Verrills, Nicole M, Dayas, Christopher V, Cairns, Murray J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Down-Regulation Exosomes - chemistry Exosomes - metabolism Humans MicroRNAs - analysis MicroRNAs - metabolism Microtubule-Associated Proteins - analysis Molecular Biology Nerve Tissue Proteins - analysis Neurites - chemistry Neurites - metabolism Neurons - metabolism Neurons - physiology Protein Biosynthesis Proteome - chemistry RNA, Messenger - metabolism Signal Transduction Transcription, Genetic
Online-Zugang:	Volltext
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