Genomic organization and evolution of double minutes/homogeneously staining regions with MYC amplification in human cancer

The mechanism for generating double minutes chromosomes (dmin) and homogeneously staining regions (hsr) in cancer is still poorly understood. Through an integrated approach combining next-generation sequencing, single nucleotide polymorphism array, fluorescent in situ hybridization and polymerase ch...

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Veröffentlicht in:	Nucleic acids research 2014-08, Vol.42 (14), p.9131-9145
Hauptverfasser:	L'Abbate, Alberto, Macchia, Gemma, D'Addabbo, Pietro, Lonoce, Angelo, Tolomeo, Doron, Trombetta, Domenico, Kok, Klaas, Bartenhagen, Christoph, Whelan, Christopher W, Palumbo, Orazio, Severgnini, Marco, Cifola, Ingrid, Dugas, Martin, Carella, Massimo, De Bellis, Gianluca, Rocchi, Mariano, Carbone, Lucia, Storlazzi, Clelia Tiziana
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Chromosomes, Human - chemistry Evolution, Molecular Gene Amplification Gene Expression Gene Fusion Genes, myc Genes, Neoplasm Genome, Human Genomics HL-60 Cells Humans Neoplasms - genetics
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