Sox2, a key factor in the regulation of pluripotency and neural differentiation
Sex determining region Y-box 2(Sox2), a member of the SoxB1 transcription factor family, is an important transcriptional regulator in pluripotent stem cells(PSCs). Together with octamer-binding transcription factor 4 and Nanog, they co-operatively control gene expression in PSCs and maintain their p...
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| Veröffentlicht in: | World journal of stem cells 2014-07, Vol.6 (3), p.305-311 |
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| container_title | World journal of stem cells |
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| creator | Zhang, Shuchen Cui, Wei |
| description | Sex determining region Y-box 2(Sox2), a member of the SoxB1 transcription factor family, is an important transcriptional regulator in pluripotent stem cells(PSCs). Together with octamer-binding transcription factor 4 and Nanog, they co-operatively control gene expression in PSCs and maintain their pluripotency. Furthermore, Sox2 plays an essential role in somatic cell reprogram-ming, reversing the epigenetic configuration of differ-entiated cells back to a pluripotent embryonic state. In addition to its role in regulation of pluripotency, Sox2 is also a critical factor for directing the differentiation of PSCs to neural progenitors and for maintaining the properties of neural progenitor stem cells. Here, we review recent findings concerning the involvement of Sox2 in pluripotency, somatic cell reprogramming and neural differentiation as well as the molecular mecha-nisms underlying these roles. |
| doi_str_mv | 10.4252/wjsc.v6.i3.305 |
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Here, we review recent findings concerning the involvement of Sox2 in pluripotency, somatic cell reprogramming and neural differentiation as well as the molecular mecha-nisms underlying these roles.</description><subject>cells</subject><subject>determining</subject><subject>differentiation</subject><subject>Neural</subject><subject>Pluripotency</subject><subject>Pluripotent</subject><subject>region</subject><subject>Reprogramming</subject><subject>Sex</subject><subject>stem</subject><subject>Topic Highlight</subject><subject>Y-box</subject><issn>1948-0210</issn><issn>1948-0210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNpVkUtvGyEURlGVqrFSb7uskLLJop7yGJiZTaXKah5SJC_arhFmLjbJGGyYceJ_H1w7lssGJD7OPZeL0BdKipIJ9v3lKZliKwvHC07EBzSiTVlPCKPk4ux8icYpPZG8SiFlyT6hSyYok7wmIzT7HV7ZN6zxM-yw1aYPETuP-yXgCIuh070LHgeL190Q3Tr04M0Oa99iD0PUHW6dtRDB9-5f9DP6aHWXYHzcr9Df219_pveTx9ndw_Tn48Rw1oiJAcsoQCPLmoqm5XNSNZZY3XIj66psBc0NaZDAai2Y4Fm40ZVgc7PviDN-hX4cuOthvoLWZIFso9bRrXTcqaCd-v_Gu6VahK0qKaes2gNujoAYNgOkXq1cMtB12kMYkqJC8IqUXNIcLQ5RE0NKEeypDCVqPwi1H4TaSuW4yt75wddzuVP8_dtz4PpIXAa_2Di_OENmAKvrquZvSmyQ7w</recordid><startdate>20140726</startdate><enddate>20140726</enddate><creator>Zhang, Shuchen</creator><creator>Cui, Wei</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140726</creationdate><title>Sox2, a key factor in the regulation of pluripotency and neural differentiation</title><author>Zhang, Shuchen ; Cui, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3295-cef21ee9648159d3b079f0fad3c6874d51305ae6e28a52532519a752bc0210323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>cells</topic><topic>determining</topic><topic>differentiation</topic><topic>Neural</topic><topic>Pluripotency</topic><topic>Pluripotent</topic><topic>region</topic><topic>Reprogramming</topic><topic>Sex</topic><topic>stem</topic><topic>Topic Highlight</topic><topic>Y-box</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Shuchen</creatorcontrib><creatorcontrib>Cui, Wei</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of stem cells</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Shuchen</au><au>Cui, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sox2, a key factor in the regulation of pluripotency and neural differentiation</atitle><jtitle>World journal of stem cells</jtitle><addtitle>World Journal of Stem Cells</addtitle><date>2014-07-26</date><risdate>2014</risdate><volume>6</volume><issue>3</issue><spage>305</spage><epage>311</epage><pages>305-311</pages><issn>1948-0210</issn><eissn>1948-0210</eissn><abstract>Sex determining region Y-box 2(Sox2), a member of the SoxB1 transcription factor family, is an important transcriptional regulator in pluripotent stem cells(PSCs). 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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | cells determining differentiation Neural Pluripotency Pluripotent region Reprogramming Sex stem Topic Highlight Y-box |
| title | Sox2, a key factor in the regulation of pluripotency and neural differentiation |
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