Skeletal Muscle Ras-Related GTP Binding B mRNA and Protein Expression Is Increased after Essential Amino Acid Ingestion in Healthy Humans

Essential amino acids (EAAs) are potent stimulators of mechanistic target of rapamycin complex 1 (mTORC1) signaling and muscle protein synthesis. However, regulators upstream of mTORC1 that are responsive to EAA availability are not well described, especially in human skeletal muscle. The purpose of...

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Veröffentlicht in:	The Journal of nutrition 2014-09, Vol.144 (9), p.1409-1414
Hauptverfasser:	Carlin, Matthew B., Tanner, Ruth E., Agergaard, Jakob, Jalili, Thunder, McClain, Donald A., Drummond, Micah J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acids, Essential - metabolism Biological and medical sciences Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Guanosine Triphosphate - metabolism Humans Leucine - metabolism Leucine-tRNA Ligase - genetics Leucine-tRNA Ligase - metabolism Male Mechanistic Target of Rapamycin Complex 1 Monomeric GTP-Binding Proteins - genetics Monomeric GTP-Binding Proteins - metabolism Multiprotein Complexes - metabolism Muscle Proteins - metabolism Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions Phosphorylation Protein Biosynthesis Protein Processing, Post-Translational Quadriceps Muscle - metabolism Reference Values RNA, Messenger - metabolism Striated muscle. Tendons TOR Serine-Threonine Kinases - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: osteoarticular system, musculoskeletal system Young Adult
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