Congenital heart disease linked to maternal autoimmunity against cardiac myosin

Structural congenital heart disease (CHD) has not previously been linked to autoimmunity. In our study, we developed an autoimmune model of structural CHD that resembles hypoplastic left heart syndrome (HLHS), a life-threatening CHD primarily affecting the left ventricle. Because cardiac myosin (CM)...

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Veröffentlicht in:	The Journal of immunology (1950) 2014-05, Vol.192 (9), p.4074-4082
Hauptverfasser:	Cole, Charles R, Yutzey, Katherine E, Brar, Anoop K, Goessling, Lisa S, Van Vickle-Chavez, Sarah J, Cunningham, Madeleine W, Eghtesady, Pirooz
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies - immunology Autoimmunity - immunology Blotting, Western Cardiac Myosins - immunology Disease Models, Animal Enzyme-Linked Immunosorbent Assay Female Heart Defects, Congenital - immunology Heart Defects, Congenital - pathology Hypoplastic Left Heart Syndrome - immunology Hypoplastic Left Heart Syndrome - pathology Immunohistochemistry Rats Rats, Inbred Lew
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