The Validity of Quasi-Steady-State Approximations in Discrete Stochastic Simulations

In biochemical networks, reactions often occur on disparate timescales and can be characterized as either fast or slow. The quasi-steady-state approximation (QSSA) utilizes timescale separation to project models of biochemical networks onto lower-dimensional slow manifolds. As a result, fast element...

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Veröffentlicht in:	Biophysical journal 2014-08, Vol.107 (3), p.783-793
Hauptverfasser:	Kim, Jae Kyoung, Josić, Krešimir, Bennett, Matthew R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Approximation Biochemistry Biophysics Chemical reactions Kinetics Metabolic Networks and Pathways Models, Theoretical Simulation Stochastic models Stochastic Processes Systems Biophysics Validation studies
Online-Zugang:	Volltext
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