Intercellular Stress Reconstitution from Traction Force Data
Cells migrate collectively during development, wound healing, and cancer metastasis. Recently, a method has been developed to recover intercellular stress in monolayers from measured traction forces upon the substrate. To calculate stress maps in two dimensions, the cell sheet was assumed to behave...
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| Veröffentlicht in: | Biophysical journal 2014-08, Vol.107 (3), p.548-554 |
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| creator | Zimmermann, Juliane Hayes, Ryan L. Basan, Markus Onuchic, José N. Rappel, Wouter-Jan Levine, Herbert |
| description | Cells migrate collectively during development, wound healing, and cancer metastasis. Recently, a method has been developed to recover intercellular stress in monolayers from measured traction forces upon the substrate. To calculate stress maps in two dimensions, the cell sheet was assumed to behave like an elastic material, and it remains unclear to what extent this assumption is valid. In this study, we simulate our recently developed model for collective cell migration, and compute intercellular stress maps using the method employed in the experiments. We also compute these maps using a method that does not depend on the traction forces or material properties. The two independently obtained stress patterns agree well for the parameters we have probed and provide a verification of the validity of the experimental method. |
| doi_str_mv | 10.1016/j.bpj.2014.06.036 |
| format | Article |
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Recently, a method has been developed to recover intercellular stress in monolayers from measured traction forces upon the substrate. To calculate stress maps in two dimensions, the cell sheet was assumed to behave like an elastic material, and it remains unclear to what extent this assumption is valid. In this study, we simulate our recently developed model for collective cell migration, and compute intercellular stress maps using the method employed in the experiments. We also compute these maps using a method that does not depend on the traction forces or material properties. 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All rights reserved.</rights><rights>Copyright Biophysical Society Aug 5, 2014</rights><rights>2014 by the Biophysical Society. 2014 Biophysical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-f432a3f9bd4ca4814d08ff5afd75dd75a8df1b552af7426c3f1b471fb28a83f03</citedby><cites>FETCH-LOGICAL-c479t-f432a3f9bd4ca4814d08ff5afd75dd75a8df1b552af7426c3f1b471fb28a83f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129476/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006349514006808$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,3537,27903,27904,53769,53771,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25099794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zimmermann, Juliane</creatorcontrib><creatorcontrib>Hayes, Ryan L.</creatorcontrib><creatorcontrib>Basan, Markus</creatorcontrib><creatorcontrib>Onuchic, José N.</creatorcontrib><creatorcontrib>Rappel, Wouter-Jan</creatorcontrib><creatorcontrib>Levine, Herbert</creatorcontrib><title>Intercellular Stress Reconstitution from Traction Force Data</title><title>Biophysical journal</title><addtitle>Biophys J</addtitle><description>Cells migrate collectively during development, wound healing, and cancer metastasis. Recently, a method has been developed to recover intercellular stress in monolayers from measured traction forces upon the substrate. To calculate stress maps in two dimensions, the cell sheet was assumed to behave like an elastic material, and it remains unclear to what extent this assumption is valid. In this study, we simulate our recently developed model for collective cell migration, and compute intercellular stress maps using the method employed in the experiments. We also compute these maps using a method that does not depend on the traction forces or material properties. The two independently obtained stress patterns agree well for the parameters we have probed and provide a verification of the validity of the experimental method.</description><subject>Biophysics</subject><subject>Cell adhesion & migration</subject><subject>Cell Biophysics</subject><subject>Cell Movement</subject><subject>Mapping</subject><subject>Models, Biological</subject><subject>Stress response</subject><subject>Stress, Mechanical</subject><subject>Surface Properties</subject><subject>Validation studies</subject><issn>0006-3495</issn><issn>1542-0086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd9L3TAUx4NM5p3bH-CLFPbiS-vJj6YtiiBuTuGCMK_PIU0TTeltrkkq7L9fuqvifPAhHA75nO_JN1-EDjAUGDA_7ot20xcEMCuAF0D5DlrgkpEcoOaf0AIAeE5ZU-6hLyH0AJiUgD-jvVSapmrYAp1ej1F7pYdhGqTPbqPXIWS_tXJjiDZO0boxM96ts5WX6l936RKf_ZBRfkW7Rg5Bf3uu--ju8ufq4ipf3vy6vjhf5opVTcwNo0RS07QdU5LVmHVQG1NK01Vll46sO4PbsiTSVIxwRVPHKmxaUsuaGqD76Gyru5nate6UHqOXg9h4u5b-j3DSiv9vRvsg7t2TYJg0rOJJ4OhZwLvHSYco1jbMpuWo3RQETsspbzCZd31_h_Zu8mOyN1MUV7SuZ0G8pZR3IXhtXh-DQczZiF6kbMScjQAuUjZp5vCti9eJlzAScLIFdPrLJ6u9CMrqUenOeq2i6Jz9QP4v0vSgCA</recordid><startdate>20140805</startdate><enddate>20140805</enddate><creator>Zimmermann, Juliane</creator><creator>Hayes, Ryan L.</creator><creator>Basan, Markus</creator><creator>Onuchic, José N.</creator><creator>Rappel, Wouter-Jan</creator><creator>Levine, Herbert</creator><general>Elsevier Inc</general><general>Biophysical Society</general><general>The Biophysical Society</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140805</creationdate><title>Intercellular Stress Reconstitution from Traction Force Data</title><author>Zimmermann, Juliane ; 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| ispartof | Biophysical journal, 2014-08, Vol.107 (3), p.548-554 |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Biophysics Cell adhesion & migration Cell Biophysics Cell Movement Mapping Models, Biological Stress response Stress, Mechanical Surface Properties Validation studies |
| title | Intercellular Stress Reconstitution from Traction Force Data |
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