Transformation of membrane nanosurface of red blood cells under hemin action
Hemin is the product of hemoglobin oxidation. Some diseases may lead to a formation of hemin. The accumulation of hemin causes destruction of red blood cells (RBC) membranes. In this study the process of development of topological defects of RBC membranes within the size range from nanoscale to micr...
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| Veröffentlicht in: | Scientific reports 2014-08, Vol.4 (1), p.6033, Article 6033 |
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| creator | Kozlova, Elena Chernysh, Alexander Moroz, Victor Gudkova, Olga Sergunova, Victoria Kuzovlev, Artem |
| description | Hemin is the product of hemoglobin oxidation. Some diseases may lead to a formation of hemin. The accumulation of hemin causes destruction of red blood cells (RBC) membranes. In this study the process of development of topological defects of RBC membranes within the size range from nanoscale to microscale levels is shown. The formation of the grain-like structures in the membrane (“grains”) with typical sizes of 120–200 nm was experimentally shown. The process of formation of “grains” was dependent on the hemin concentration and incubation time. The possible mechanism of membrane nanostructure alterations is proposed. The kinetic equations of formation and transformation of small and medium topological defects were analyzed. This research can be used to study the cell intoxication and analyze the action of various agents on RBC membranes. |
| doi_str_mv | 10.1038/srep06033 |
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Some diseases may lead to a formation of hemin. The accumulation of hemin causes destruction of red blood cells (RBC) membranes. In this study the process of development of topological defects of RBC membranes within the size range from nanoscale to microscale levels is shown. The formation of the grain-like structures in the membrane (“grains”) with typical sizes of 120–200 nm was experimentally shown. The process of formation of “grains” was dependent on the hemin concentration and incubation time. The possible mechanism of membrane nanostructure alterations is proposed. The kinetic equations of formation and transformation of small and medium topological defects were analyzed. This research can be used to study the cell intoxication and analyze the action of various agents on RBC membranes.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep06033</identifier><identifier>PMID: 25112597</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>14/3 ; 631/80/2373/2238 ; 639/925/352/1060 ; Erythrocyte Membrane - chemistry ; Erythrocyte Membrane - metabolism ; Erythrocyte Membrane - ultrastructure ; Erythrocytes ; Erythrocytes - cytology ; Erythrocytes - metabolism ; Hemin ; Hemin - chemistry ; Hemin - metabolism ; Hemoglobin ; Humanities and Social Sciences ; Humans ; Intoxication ; Kinetics ; Mathematical models ; Membranes ; Microscopy, Atomic Force ; multidisciplinary ; Nanostructures - chemistry ; Oxidation ; Science</subject><ispartof>Scientific reports, 2014-08, Vol.4 (1), p.6033, Article 6033</ispartof><rights>The Author(s) 2014</rights><rights>Copyright Nature Publishing Group Aug 2014</rights><rights>Copyright © 2014, Macmillan Publishers Limited. All rights reserved 2014 Macmillan Publishers Limited. All rights reserved</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-b8889cd6157ab2fcdd9ee53d6ead8cee4142eb852d798421969885e6d9c498c93</citedby><cites>FETCH-LOGICAL-c504t-b8889cd6157ab2fcdd9ee53d6ead8cee4142eb852d798421969885e6d9c498c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129419/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129419/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25112597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kozlova, Elena</creatorcontrib><creatorcontrib>Chernysh, Alexander</creatorcontrib><creatorcontrib>Moroz, Victor</creatorcontrib><creatorcontrib>Gudkova, Olga</creatorcontrib><creatorcontrib>Sergunova, Victoria</creatorcontrib><creatorcontrib>Kuzovlev, Artem</creatorcontrib><title>Transformation of membrane nanosurface of red blood cells under hemin action</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Hemin is the product of hemoglobin oxidation. Some diseases may lead to a formation of hemin. The accumulation of hemin causes destruction of red blood cells (RBC) membranes. In this study the process of development of topological defects of RBC membranes within the size range from nanoscale to microscale levels is shown. The formation of the grain-like structures in the membrane (“grains”) with typical sizes of 120–200 nm was experimentally shown. The process of formation of “grains” was dependent on the hemin concentration and incubation time. The possible mechanism of membrane nanostructure alterations is proposed. The kinetic equations of formation and transformation of small and medium topological defects were analyzed. 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Chernysh, Alexander ; Moroz, Victor ; Gudkova, Olga ; Sergunova, Victoria ; Kuzovlev, Artem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-b8889cd6157ab2fcdd9ee53d6ead8cee4142eb852d798421969885e6d9c498c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>14/3</topic><topic>631/80/2373/2238</topic><topic>639/925/352/1060</topic><topic>Erythrocyte Membrane - chemistry</topic><topic>Erythrocyte Membrane - metabolism</topic><topic>Erythrocyte Membrane - ultrastructure</topic><topic>Erythrocytes</topic><topic>Erythrocytes - cytology</topic><topic>Erythrocytes - metabolism</topic><topic>Hemin</topic><topic>Hemin - chemistry</topic><topic>Hemin - metabolism</topic><topic>Hemoglobin</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Intoxication</topic><topic>Kinetics</topic><topic>Mathematical models</topic><topic>Membranes</topic><topic>Microscopy, Atomic Force</topic><topic>multidisciplinary</topic><topic>Nanostructures - chemistry</topic><topic>Oxidation</topic><topic>Science</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kozlova, Elena</creatorcontrib><creatorcontrib>Chernysh, Alexander</creatorcontrib><creatorcontrib>Moroz, Victor</creatorcontrib><creatorcontrib>Gudkova, Olga</creatorcontrib><creatorcontrib>Sergunova, Victoria</creatorcontrib><creatorcontrib>Kuzovlev, Artem</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kozlova, Elena</au><au>Chernysh, Alexander</au><au>Moroz, Victor</au><au>Gudkova, Olga</au><au>Sergunova, Victoria</au><au>Kuzovlev, Artem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transformation of membrane nanosurface of red blood cells under hemin action</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2014-08-12</date><risdate>2014</risdate><volume>4</volume><issue>1</issue><spage>6033</spage><pages>6033-</pages><artnum>6033</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Hemin is the product of hemoglobin oxidation. Some diseases may lead to a formation of hemin. The accumulation of hemin causes destruction of red blood cells (RBC) membranes. In this study the process of development of topological defects of RBC membranes within the size range from nanoscale to microscale levels is shown. The formation of the grain-like structures in the membrane (“grains”) with typical sizes of 120–200 nm was experimentally shown. The process of formation of “grains” was dependent on the hemin concentration and incubation time. The possible mechanism of membrane nanostructure alterations is proposed. The kinetic equations of formation and transformation of small and medium topological defects were analyzed. This research can be used to study the cell intoxication and analyze the action of various agents on RBC membranes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25112597</pmid><doi>10.1038/srep06033</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 14/3 631/80/2373/2238 639/925/352/1060 Erythrocyte Membrane - chemistry Erythrocyte Membrane - metabolism Erythrocyte Membrane - ultrastructure Erythrocytes Erythrocytes - cytology Erythrocytes - metabolism Hemin Hemin - chemistry Hemin - metabolism Hemoglobin Humanities and Social Sciences Humans Intoxication Kinetics Mathematical models Membranes Microscopy, Atomic Force multidisciplinary Nanostructures - chemistry Oxidation Science |
| title | Transformation of membrane nanosurface of red blood cells under hemin action |
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