Identification and Validation of Genetic Variants that Influence Transcription Factor and Cell Signaling Protein Levels

Many genetic variants associated with human disease have been found to be associated with alterations in mRNA expression. Although it is commonly assumed that mRNA expression changes will lead to consequent changes in protein levels, methodological challenges have limited our ability to test the deg...

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Veröffentlicht in:	American journal of human genetics 2014-08, Vol.95 (2), p.194-208
Hauptverfasser:	Hause, Ronald J., Stark, Amy L., Antao, Nirav N., Gorsic, Lidija K., Chung, Sophie H., Brown, Christopher D., Wong, Shan S., Gill, Daniel F., Myers, Jamie L., To, Lida Anita, White, Kevin P., Dolan, M. Eileen, Jones, Richard Baker
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - genetics Antibodies - immunology Base Sequence Cell Line Chromosome Mapping DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Gene Expression Genetic Variation Genetics Genome, Human - genetics Genome-Wide Association Study Genomics Genotype Genotype & phenotype Humans Models, Genetic Protein Array Analysis Proteins Proteins - genetics Proteins - metabolism Proteome - genetics Quantitative Trait Loci - genetics Ribonucleic acid RNA RNA Interference RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Small Interfering Sequence Analysis, DNA Signal Transduction - genetics Transcription Factors - genetics Transcriptome - genetics
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