Dipyrone metabolite 4‐MAA induces hypothermia and inhibits PGE2‐dependent and ‐independent fever while 4‐AA only blocks PGE2‐dependent fever

Background and Purpose The antipyretic and hypothermic prodrug dipyrone prevents PGE2‐dependent and ‐independent fever induced by LPS from Escherichia coli and Tityus serrulatus venom (Tsv) respectively. We aimed to identify the dipyrone metabolites responsible for the antipyretic and hypothermic ef...

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Veröffentlicht in:	British journal of pharmacology 2014-08, Vol.171 (15), p.3666-3679
Hauptverfasser:	Malvar, David do C, Aguiar, Fernando A, Vaz, Artur de L L, Assis, Débora C R, Melo, Miriam C C, Jabor, Valquíria A P, Kalapothakis, Evanguedes, Ferreira, Sérgio H, Clososki, Giuliano C, Souza, Glória E P
Format:	Artikel
Sprache:	eng
Schlagworte:	Ampyrone - blood Ampyrone - cerebrospinal fluid Ampyrone - metabolism Ampyrone - pharmacology Animals Antipyretics - blood Antipyretics - cerebrospinal fluid Antipyretics - pharmacokinetics Antipyretics - pharmacology Body Temperature - drug effects Dinoprostone - cerebrospinal fluid Dinoprostone - metabolism dipyrone Dipyrone - analogs & derivatives Dipyrone - blood Dipyrone - cerebrospinal fluid Dipyrone - metabolism Dipyrone - pharmacokinetics Dipyrone - pharmacology dipyrone metabolites fever Fever - chemically induced Fever - drug therapy Fever - metabolism Hypothalamus - drug effects Hypothalamus - metabolism hypothermia Hypothermia - chemically induced Hypothermia - metabolism Indomethacin - pharmacology Lipopolysaccharides LPS Male Prodrugs - pharmacokinetics Rats, Wistar Research Papers Scorpion Venoms Tityus serrulatus venom
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