Mismatch repair protein expression in 1049 endometrial carcinomas, associations with body mass index, and other clinicopathologic variables

Abstract Objective Links between obesity, with its attendant estrogen abnormalities, and the endometrial carcinoma (EC) DNA Mismatch Repair Protein (MMR) system have recently been proposed. We investigated relationships between body mass index (BMI) and clinicopathological correlates including MMR e...

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Veröffentlicht in:	Gynecologic oncology 2014-04, Vol.133 (1), p.43-47
Hauptverfasser:	Joehlin-Price, Amy S, Perrino, Carmen M, Stephens, Julie, Backes, Floor J, Goodfellow, Paul J, Cohn, David E, Suarez, Adrian A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Adenocarcinoma, Clear Cell - complications Adenocarcinoma, Clear Cell - metabolism Adenosine Triphosphatases - metabolism Adult Aged Aged, 80 and over Biomarkers, Tumor - metabolism BMI Body Mass Index Carcinoma - complications Carcinoma - metabolism Carcinoma, Endometrioid - complications Carcinoma, Endometrioid - metabolism Carcinosarcoma - complications Carcinosarcoma - metabolism DNA Mismatch Repair DNA mismatch repair protein DNA Repair Enzymes - metabolism DNA-Binding Proteins - metabolism Endometrial cancer Endometrial Neoplasms - complications Endometrial Neoplasms - metabolism Female Hematology, Oncology and Palliative Medicine Humans Middle Aged Mismatch Repair Endonuclease PMS2 MMR Multivariate Analysis MutL Protein Homolog 1 MutS Homolog 2 Protein - metabolism Nuclear Proteins - metabolism Obesity - complications Obesity - metabolism Obstetrics and Gynecology Overweight - complications Overweight - metabolism Retrospective Studies
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