Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS

Neuroinflammation is a prominent pathological feature in the spinal cords of patients with amyotrophic lateral sclerosis (ALS), as well as in transgenic mouse models of inherited ALS, and is characterized by activated microglia. Earlier studies showed that activated microglia play important roles in...

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Veröffentlicht in:	Experimental neurology 2012-09, Vol.237 (1), p.147-152
Hauptverfasser:	Liao, Bing, Zhao, Weihua, Beers, David R., Henkel, Jenny S., Appel, Stanley H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - enzymology Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - prevention & control Animal models Animals Astrocytes - enzymology Astrocytes - pathology Biological and medical sciences Brain-derived neurotrophic factor CD163 antigen Cells, Cultured Coculture Techniques CYBB protein Disease Models, Animal Humans Inflammation Inflammation - enzymology Inflammation - genetics Inflammation - prevention & control Medical sciences Mice Mice, Inbred C57BL Mice, Neurologic Mutants Mice, Transgenic Microglia Microglia - enzymology Microglia - pathology Miscellaneous Motor neurons Motor Neurons - enzymology Motor Neurons - pathology mRNA Neurology Neuroprotection Neurotoxicity Phenotype Spinal cord Superoxide dismutase Superoxide Dismutase - biosynthesis Superoxide Dismutase - genetics Survival Toxicology Transformation Transformation, Genetic Transgenic mice
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