Phosphoproteome Dynamics in Onset and Maintenance of Oncogene-induced Senescence

Expression of the BRAFV600E oncoprotein is known to cause benign lesions, such as melanocytic nevi (moles). Despite the oncogenic function of mutant BRAF, these lesions are arrested by a cell-autonomous mechanism called oncogene-induced senescence. Infrequently, nevi can progress to malignant melano...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular & cellular proteomics 2014-08, Vol.13 (8), p.2089-2100
Hauptverfasser:	de Graaf, Erik L., Kaplon, Joanna, Zhou, Houjiang, Heck, Albert J.R., Peeper, Daniel S., Altelaar, A. F. Maarten
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Cellular Senescence Databases, Genetic Gene Expression Regulation, Neoplastic Humans Oncogenes Phosphorylation Proteomics - methods Proto-Oncogene Proteins B-raf - metabolism Signal Transduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!