Potential Therapeutic Strategies for Alzheimer’s Disease Targeting or Beyond β-Amyloid : Insights from Clinical Trials
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with two hallmarks: β-amyloid plagues and neurofibrillary tangles. It is one of the most alarming illnesses to elderly people. No effective drugs and therapies have been developed, while mechanism-based explorations of therapeutic...
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| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-22 |
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| creator | Jia, Qiutian Deng, Yulin Qing, Hong |
| description | Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with two hallmarks: β-amyloid plagues and neurofibrillary tangles. It is one of the most alarming illnesses to elderly people. No effective drugs and therapies have been developed, while mechanism-based explorations of therapeutic approaches have been intensively investigated. Outcomes of clinical trials suggested several pitfalls in the choice of biomarkers, development of drug candidates, and interaction of drug-targeted molecules; however, they also aroused concerns on the potential deficiency in our understanding of pathogenesis of AD, and ultimately stimulated the advent of novel drug targets tests. The anticipated increase of AD patients in next few decades makes development of better therapy an urgent issue. Here we attempt to summarize and compare putative therapeutic strategies that have completed clinical trials or are currently being tested from various perspectives to provide insights for treatments of Alzheimer’s disease. |
| doi_str_mv | 10.1155/2014/837157 |
| format | Article |
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Here we attempt to summarize and compare putative therapeutic strategies that have completed clinical trials or are currently being tested from various perspectives to provide insights for treatments of Alzheimer’s disease.</description><subject>Alzheimer Disease - drug therapy</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer Disease - pathology</subject><subject>Amyloid beta-Peptides - antagonists & inhibitors</subject><subject>Amyloid beta-Peptides - genetics</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>Biomarkers - metabolism</subject><subject>Clinical Trials as Topic</subject><subject>Humans</subject><subject>Molecular Targeted Therapy</subject><subject>Neurofibrillary Tangles - pathology</subject><subject>Review</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQhyMEolXpiTPIR0QV6on_JRyQlqWUSpVAYjlbbjxJjJJ4sbOg7YnX4DV4kD4ET1KvUlZwqi9jyZ--mfEvy54CfQUgxGlBgZ-WTIFQD7LDggHPJXB4uL8zdpAdx_iVplOCpJV8nB0UApiUjB5m209-wnFypierDoNZ42ZyNfk8BTNh6zCSxgey6K87dAOGPz9_RfLORTQRycqEFic3tiQhb3HrR0tufueLYdt7Z8lrcjFG13ZTcgQ_kGXvRlfvGoXULj7JHjWp4PFdPcq-vD9bLT_klx_PL5aLy7zmCqa8MKqiqm4Ut4LL0jJGa4ucSlmALNEg51hKyytJRQWVKjk2lcUrEKVEBZYdZW9m73pzNaCt07bB9Hod3GDCVnvj9P8vo-t0679rDgVXokyCF3eC4L9tME56cLHGvjcj-k3UICF9LKiK3Y8KKcuiAMoTejKjdfAxBmz2EwHVu2j1Llo9R5vo5_8usWf_BpmAlzPQudGaH-4e27MZxoRgY_awoAVVkt0C5m23EQ</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Jia, Qiutian</creator><creator>Deng, Yulin</creator><creator>Qing, Hong</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7SS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6347-798X</orcidid></search><sort><creationdate>20140101</creationdate><title>Potential Therapeutic Strategies for Alzheimer’s Disease Targeting or Beyond β-Amyloid : Insights from Clinical Trials</title><author>Jia, Qiutian ; Deng, Yulin ; Qing, Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-2a7907cf74d5468d330cde40662168eae44e86d49605919784ef9deb1586e71d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alzheimer Disease - drug therapy</topic><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer Disease - pathology</topic><topic>Amyloid beta-Peptides - antagonists & inhibitors</topic><topic>Amyloid beta-Peptides - genetics</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>Biomarkers - metabolism</topic><topic>Clinical Trials as Topic</topic><topic>Humans</topic><topic>Molecular Targeted Therapy</topic><topic>Neurofibrillary Tangles - pathology</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jia, Qiutian</creatorcontrib><creatorcontrib>Deng, Yulin</creatorcontrib><creatorcontrib>Qing, Hong</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jia, Qiutian</au><au>Deng, Yulin</au><au>Qing, Hong</au><au>King, Tan E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential Therapeutic Strategies for Alzheimer’s Disease Targeting or Beyond β-Amyloid : Insights from Clinical Trials</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>22</epage><pages>1-22</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with two hallmarks: β-amyloid plagues and neurofibrillary tangles. It is one of the most alarming illnesses to elderly people. No effective drugs and therapies have been developed, while mechanism-based explorations of therapeutic approaches have been intensively investigated. Outcomes of clinical trials suggested several pitfalls in the choice of biomarkers, development of drug candidates, and interaction of drug-targeted molecules; however, they also aroused concerns on the potential deficiency in our understanding of pathogenesis of AD, and ultimately stimulated the advent of novel drug targets tests. The anticipated increase of AD patients in next few decades makes development of better therapy an urgent issue. 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| source | MEDLINE; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Alzheimer Disease - drug therapy Alzheimer Disease - genetics Alzheimer Disease - pathology Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Biomarkers - metabolism Clinical Trials as Topic Humans Molecular Targeted Therapy Neurofibrillary Tangles - pathology Review |
| title | Potential Therapeutic Strategies for Alzheimer’s Disease Targeting or Beyond β-Amyloid : Insights from Clinical Trials |
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