A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication

Cell cycle arrest in response to hypoxia is a fundamental physiological mechanism to maintain a balance between O(2) supply and demand. Many of the cellular responses to reduced O(2) availability are mediated through the transcriptional activity of hypoxia-inducible factor 1 (HIF-1). We report a rol...

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Veröffentlicht in:	Science signaling 2013-02, Vol.6 (262), p.ra10-ra10
Hauptverfasser:	Hubbi, Maimon E, Kshitiz, Gilkes, Daniele M, Rey, Sergio, Wong, Carmen C, Luo, Weibo, Kim, Deok-Ho, Dang, Chi V, Levchenko, Andre, Semenza, Gregg L
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Proteins - metabolism Cell Line, Tumor Cell Nucleus - metabolism Cell Proliferation Chromatin - metabolism DNA Replication Humans Hypoxia-Inducible Factor 1, alpha Subunit - physiology Nuclear Proteins - metabolism Phosphorylation Transcription, Genetic
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