Alveolar nitric oxide and its role in pediatric asthma control assessment
Nitric oxide can be measured at multiple flow rates to determine proximal (maximum airway nitric oxide flux; JawNO) and distal inflammation (alveolar nitric oxide concentration; CANO). The main aim was to study the association among symptoms, lung function, proximal (maximum airway nitric oxide flux...
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| Veröffentlicht in: | BMC pulmonary medicine 2014-08, Vol.14 (1), p.126-126, Article 126 |
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| description | Nitric oxide can be measured at multiple flow rates to determine proximal (maximum airway nitric oxide flux; JawNO) and distal inflammation (alveolar nitric oxide concentration; CANO). The main aim was to study the association among symptoms, lung function, proximal (maximum airway nitric oxide flux) and distal (alveolar nitric oxide concentration) airway inflammation in asthmatic children treated and not treated with inhaled glucocorticoids.
A cross-sectional study with prospective data collection was carried out in a consecutive sample of girls and boys aged between 6 and 16 years with a medical diagnosis of asthma. Maximum airway nitric oxide flux and alveolar nitric oxide concentration were calculated according to the two-compartment model. In asthmatic patients, the asthma control questionnaire (CAN) was completed and forced spirometry was performed. In controls, differences between the sexes in alveolar nitric oxide concentration and maximum airway nitric oxide flux and their correlation with height were studied. The correlation among the fraction of exhaled NO at 50 ml/s (FENO50), CANO, JawNO, forced expiratory volume in 1 second (FEV1) and the CAN questionnaire was measured and the degree of agreement regarding asthma control assessment was studied using Cohen's kappa.
We studied 162 children; 49 healthy (group 1), 23 asthmatic participants without treatment (group 2) and 80 asthmatic patients treated with inhaled corticosteroids (group 3). CANO (ppb) was 2.2 (0.1-4.5), 3 (0.2-9.2) and 2.45 (0.1-24), respectively. JawNO (pl/s) was 516 (98.3-1470), 2356.67 (120-6110) and 1426 (156-11805), respectively. There was a strong association (r=0.97) between FENO50 and JawNO and the degree of agreement was very good in group 2 and was good in group 3. There was no agreement or only slight agreement between the measures used to monitor asthma control (FEV1, CAN questionnaire, CANO and JawNO).
The results for CANO and JawNO in controls were similar to those found in other reports. There was no agreement or only slight agreement among the three measure instruments analyzed to assess asthma control. In our sample, no additional information was provided by CANO and JawNO. |
| doi_str_mv | 10.1186/1471-2466-14-126 |
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A cross-sectional study with prospective data collection was carried out in a consecutive sample of girls and boys aged between 6 and 16 years with a medical diagnosis of asthma. Maximum airway nitric oxide flux and alveolar nitric oxide concentration were calculated according to the two-compartment model. In asthmatic patients, the asthma control questionnaire (CAN) was completed and forced spirometry was performed. In controls, differences between the sexes in alveolar nitric oxide concentration and maximum airway nitric oxide flux and their correlation with height were studied. The correlation among the fraction of exhaled NO at 50 ml/s (FENO50), CANO, JawNO, forced expiratory volume in 1 second (FEV1) and the CAN questionnaire was measured and the degree of agreement regarding asthma control assessment was studied using Cohen's kappa.
We studied 162 children; 49 healthy (group 1), 23 asthmatic participants without treatment (group 2) and 80 asthmatic patients treated with inhaled corticosteroids (group 3). CANO (ppb) was 2.2 (0.1-4.5), 3 (0.2-9.2) and 2.45 (0.1-24), respectively. JawNO (pl/s) was 516 (98.3-1470), 2356.67 (120-6110) and 1426 (156-11805), respectively. There was a strong association (r=0.97) between FENO50 and JawNO and the degree of agreement was very good in group 2 and was good in group 3. There was no agreement or only slight agreement between the measures used to monitor asthma control (FEV1, CAN questionnaire, CANO and JawNO).
The results for CANO and JawNO in controls were similar to those found in other reports. There was no agreement or only slight agreement among the three measure instruments analyzed to assess asthma control. In our sample, no additional information was provided by CANO and JawNO.</description><identifier>ISSN: 1471-2466</identifier><identifier>EISSN: 1471-2466</identifier><identifier>DOI: 10.1186/1471-2466-14-126</identifier><identifier>PMID: 25090994</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Administration, Inhalation ; Adolescent ; Agreements ; Airway management ; Allergies ; Analysis ; Asthma ; Asthma - drug therapy ; Asthma - metabolism ; Asthma - physiopathology ; Biomedical research ; Body Height ; Breath Tests ; Child ; Clinical medicine ; Cross-Sectional Studies ; Disease control ; Drug therapy ; Family medical history ; Female ; Food allergies ; Forced Expiratory Volume ; Glucocorticoids - administration & dosage ; Healthy Volunteers ; Humans ; Inflammation - metabolism ; Male ; Mathematical models ; Measurement ; Nitric oxide ; Nitric Oxide - analysis ; Nitric Oxide - metabolism ; Pediatrics ; Prospective Studies ; Pulmonary Alveoli - chemistry ; Pulmonary Alveoli - metabolism ; Pulmonology ; Questionnaires ; Surveys and Questionnaires ; Values</subject><ispartof>BMC pulmonary medicine, 2014-08, Vol.14 (1), p.126-126, Article 126</ispartof><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>2014 Sardón et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>Copyright © 2014 Sardón et al.; licensee BioMed Central Ltd. 2014 Sardón et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b551t-48b39631e54e72216498a9a9c6c9fd055d590462f1f6f057458bea8fae81d4c03</citedby><cites>FETCH-LOGICAL-b551t-48b39631e54e72216498a9a9c6c9fd055d590462f1f6f057458bea8fae81d4c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124482/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124482/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25090994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sardón, Olaia</creatorcontrib><creatorcontrib>Corcuera, Paula</creatorcontrib><creatorcontrib>Aldasoro, Ane</creatorcontrib><creatorcontrib>Korta, Javier</creatorcontrib><creatorcontrib>Mintegui, Javier</creatorcontrib><creatorcontrib>Emparanza, José I</creatorcontrib><creatorcontrib>Pérez-Yarza, Eduardo G</creatorcontrib><title>Alveolar nitric oxide and its role in pediatric asthma control assessment</title><title>BMC pulmonary medicine</title><addtitle>BMC Pulm Med</addtitle><description>Nitric oxide can be measured at multiple flow rates to determine proximal (maximum airway nitric oxide flux; JawNO) and distal inflammation (alveolar nitric oxide concentration; CANO). The main aim was to study the association among symptoms, lung function, proximal (maximum airway nitric oxide flux) and distal (alveolar nitric oxide concentration) airway inflammation in asthmatic children treated and not treated with inhaled glucocorticoids.
A cross-sectional study with prospective data collection was carried out in a consecutive sample of girls and boys aged between 6 and 16 years with a medical diagnosis of asthma. Maximum airway nitric oxide flux and alveolar nitric oxide concentration were calculated according to the two-compartment model. In asthmatic patients, the asthma control questionnaire (CAN) was completed and forced spirometry was performed. In controls, differences between the sexes in alveolar nitric oxide concentration and maximum airway nitric oxide flux and their correlation with height were studied. The correlation among the fraction of exhaled NO at 50 ml/s (FENO50), CANO, JawNO, forced expiratory volume in 1 second (FEV1) and the CAN questionnaire was measured and the degree of agreement regarding asthma control assessment was studied using Cohen's kappa.
We studied 162 children; 49 healthy (group 1), 23 asthmatic participants without treatment (group 2) and 80 asthmatic patients treated with inhaled corticosteroids (group 3). CANO (ppb) was 2.2 (0.1-4.5), 3 (0.2-9.2) and 2.45 (0.1-24), respectively. JawNO (pl/s) was 516 (98.3-1470), 2356.67 (120-6110) and 1426 (156-11805), respectively. There was a strong association (r=0.97) between FENO50 and JawNO and the degree of agreement was very good in group 2 and was good in group 3. There was no agreement or only slight agreement between the measures used to monitor asthma control (FEV1, CAN questionnaire, CANO and JawNO).
The results for CANO and JawNO in controls were similar to those found in other reports. There was no agreement or only slight agreement among the three measure instruments analyzed to assess asthma control. In our sample, no additional information was provided by CANO and JawNO.</description><subject>Administration, Inhalation</subject><subject>Adolescent</subject><subject>Agreements</subject><subject>Airway management</subject><subject>Allergies</subject><subject>Analysis</subject><subject>Asthma</subject><subject>Asthma - drug therapy</subject><subject>Asthma - metabolism</subject><subject>Asthma - physiopathology</subject><subject>Biomedical research</subject><subject>Body Height</subject><subject>Breath Tests</subject><subject>Child</subject><subject>Clinical medicine</subject><subject>Cross-Sectional Studies</subject><subject>Disease control</subject><subject>Drug therapy</subject><subject>Family medical history</subject><subject>Female</subject><subject>Food allergies</subject><subject>Forced Expiratory Volume</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Inflammation - metabolism</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Measurement</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - analysis</subject><subject>Nitric Oxide - metabolism</subject><subject>Pediatrics</subject><subject>Prospective Studies</subject><subject>Pulmonary Alveoli - chemistry</subject><subject>Pulmonary Alveoli - metabolism</subject><subject>Pulmonology</subject><subject>Questionnaires</subject><subject>Surveys and Questionnaires</subject><subject>Values</subject><issn>1471-2466</issn><issn>1471-2466</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1UsFu1DAQtRCIlsKdE4rEhUuKx7Ed-4K0WhWoVKkXOFuOM2ldJfZiZyv4-zrdsnRRKx88njfzZuZ5CHkP9BRAyc_AW6gZl7IGXgOTL8jx3vXykX1E3uR8Qym0SjSvyRETVFOt-TE5X423GEebquDn5F0Vf_seKxv6ys-5SnHEyodqg72397jN8_VkKxfDXMDyzJjzhGF-S14Ndsz47uE-IT-_nv1Yf68vLr-dr1cXdScEzDVXXaNlAyg4toyB5FpZbbWTTg89FaIXmnLJBhjkQEXLherQqsGigp472pyQLzvezbabsHeldLKj2SQ_2fTHROvNIRL8tbmKt4YD41yxQrDeEXQ-PkNwiLg4mUVKs0hZLFOULiyfHtpI8dcW82wmnx2Oow0Yt9mAEKxpQcPS8cf_Qm_iNoUi0n0UlKEp_Iu6siMaH4ZYiruF1KxEo4VuFFuaP30iqpweJ18-BQdf_AcJdJfgUsw54bAfFKhZluip0T48Vnif8HdrmjvERMCS</recordid><startdate>20140804</startdate><enddate>20140804</enddate><creator>Sardón, Olaia</creator><creator>Corcuera, Paula</creator><creator>Aldasoro, Ane</creator><creator>Korta, Javier</creator><creator>Mintegui, Javier</creator><creator>Emparanza, José I</creator><creator>Pérez-Yarza, Eduardo G</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140804</creationdate><title>Alveolar nitric oxide and its role in pediatric asthma control assessment</title><author>Sardón, Olaia ; Corcuera, Paula ; Aldasoro, Ane ; Korta, Javier ; Mintegui, Javier ; Emparanza, José I ; Pérez-Yarza, Eduardo G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b551t-48b39631e54e72216498a9a9c6c9fd055d590462f1f6f057458bea8fae81d4c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Administration, Inhalation</topic><topic>Adolescent</topic><topic>Agreements</topic><topic>Airway management</topic><topic>Allergies</topic><topic>Analysis</topic><topic>Asthma</topic><topic>Asthma - drug therapy</topic><topic>Asthma - metabolism</topic><topic>Asthma - physiopathology</topic><topic>Biomedical research</topic><topic>Body Height</topic><topic>Breath Tests</topic><topic>Child</topic><topic>Clinical medicine</topic><topic>Cross-Sectional Studies</topic><topic>Disease control</topic><topic>Drug therapy</topic><topic>Family medical history</topic><topic>Female</topic><topic>Food allergies</topic><topic>Forced Expiratory Volume</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>Inflammation - metabolism</topic><topic>Male</topic><topic>Mathematical models</topic><topic>Measurement</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - analysis</topic><topic>Nitric Oxide - metabolism</topic><topic>Pediatrics</topic><topic>Prospective Studies</topic><topic>Pulmonary Alveoli - chemistry</topic><topic>Pulmonary Alveoli - metabolism</topic><topic>Pulmonology</topic><topic>Questionnaires</topic><topic>Surveys and Questionnaires</topic><topic>Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sardón, Olaia</creatorcontrib><creatorcontrib>Corcuera, Paula</creatorcontrib><creatorcontrib>Aldasoro, Ane</creatorcontrib><creatorcontrib>Korta, Javier</creatorcontrib><creatorcontrib>Mintegui, Javier</creatorcontrib><creatorcontrib>Emparanza, José I</creatorcontrib><creatorcontrib>Pérez-Yarza, Eduardo G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC pulmonary medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sardón, Olaia</au><au>Corcuera, Paula</au><au>Aldasoro, Ane</au><au>Korta, Javier</au><au>Mintegui, Javier</au><au>Emparanza, José I</au><au>Pérez-Yarza, Eduardo G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alveolar nitric oxide and its role in pediatric asthma control assessment</atitle><jtitle>BMC pulmonary medicine</jtitle><addtitle>BMC Pulm Med</addtitle><date>2014-08-04</date><risdate>2014</risdate><volume>14</volume><issue>1</issue><spage>126</spage><epage>126</epage><pages>126-126</pages><artnum>126</artnum><issn>1471-2466</issn><eissn>1471-2466</eissn><abstract>Nitric oxide can be measured at multiple flow rates to determine proximal (maximum airway nitric oxide flux; JawNO) and distal inflammation (alveolar nitric oxide concentration; CANO). The main aim was to study the association among symptoms, lung function, proximal (maximum airway nitric oxide flux) and distal (alveolar nitric oxide concentration) airway inflammation in asthmatic children treated and not treated with inhaled glucocorticoids.
A cross-sectional study with prospective data collection was carried out in a consecutive sample of girls and boys aged between 6 and 16 years with a medical diagnosis of asthma. Maximum airway nitric oxide flux and alveolar nitric oxide concentration were calculated according to the two-compartment model. In asthmatic patients, the asthma control questionnaire (CAN) was completed and forced spirometry was performed. In controls, differences between the sexes in alveolar nitric oxide concentration and maximum airway nitric oxide flux and their correlation with height were studied. The correlation among the fraction of exhaled NO at 50 ml/s (FENO50), CANO, JawNO, forced expiratory volume in 1 second (FEV1) and the CAN questionnaire was measured and the degree of agreement regarding asthma control assessment was studied using Cohen's kappa.
We studied 162 children; 49 healthy (group 1), 23 asthmatic participants without treatment (group 2) and 80 asthmatic patients treated with inhaled corticosteroids (group 3). CANO (ppb) was 2.2 (0.1-4.5), 3 (0.2-9.2) and 2.45 (0.1-24), respectively. JawNO (pl/s) was 516 (98.3-1470), 2356.67 (120-6110) and 1426 (156-11805), respectively. There was a strong association (r=0.97) between FENO50 and JawNO and the degree of agreement was very good in group 2 and was good in group 3. There was no agreement or only slight agreement between the measures used to monitor asthma control (FEV1, CAN questionnaire, CANO and JawNO).
The results for CANO and JawNO in controls were similar to those found in other reports. There was no agreement or only slight agreement among the three measure instruments analyzed to assess asthma control. In our sample, no additional information was provided by CANO and JawNO.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>25090994</pmid><doi>10.1186/1471-2466-14-126</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Inhalation Adolescent Agreements Airway management Allergies Analysis Asthma Asthma - drug therapy Asthma - metabolism Asthma - physiopathology Biomedical research Body Height Breath Tests Child Clinical medicine Cross-Sectional Studies Disease control Drug therapy Family medical history Female Food allergies Forced Expiratory Volume Glucocorticoids - administration & dosage Healthy Volunteers Humans Inflammation - metabolism Male Mathematical models Measurement Nitric oxide Nitric Oxide - analysis Nitric Oxide - metabolism Pediatrics Prospective Studies Pulmonary Alveoli - chemistry Pulmonary Alveoli - metabolism Pulmonology Questionnaires Surveys and Questionnaires Values |
| title | Alveolar nitric oxide and its role in pediatric asthma control assessment |
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