Value of mink vomit model in study of anti-emetic drugs
AIM： To establish a new, reliable vomit model of minks METHODS： Adult male minks were randomly divided into 8 groups （n=6）： cisplatin （7.5 mg/kg） intraperitoneal injection （ip） group, copper sulfate （40 mg/kg） intragastric injection （ig） group, apomorphine （1.6 mg/kg） subcutaneous injection （sc） gro...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2006-02, Vol.12 (8), p.1300-1302 |
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| creator | Zhang, Fang Wang, Lei Yang, Zhi-Hong Liu, Zhan-Tao Yue, Wang |
| description | AIM： To establish a new, reliable vomit model of minks
METHODS： Adult male minks were randomly divided into 8 groups （n=6）： cisplatin （7.5 mg/kg） intraperitoneal injection （ip） group, copper sulfate （40 mg/kg） intragastric injection （ig） group, apomorphine （1.6 mg/kg） subcutaneous injection （sc） group, and 18 Gy whole-body X-irradiation group, ondansetron injection group （2 mg/kg ip） 30 min later followed by cisplatin （7.5 mg/kg） ip, normal saline （NS） ip injection control group, metoclopramide injection group （4 mg/kg ip） 30 rain later followed by apomorphine （1.6 mg/kg） sc, NS ig control group. The frequency of retching and vomiting was calculated. After behavioral experiment, distribution of 5-HT in the ileum was detected by immunohistologic method. RESULTS： Cisplatin, apomorphine, copper sulfate and X-irradiation administered to minks evoked a profound emetic response in the animals. However, retching and vomiting were significantly inhibited by pretreatment with ondansetron and metoclopramide in cisplatin and copper sulfate groups （P=0.018）. Immunohistologic result showed that 5-HT released from enterochromaffin cells （EC cells） was involved in vomiting mechanism.
CONCLUSION： Mink vomit model has a great value in studying the vomiting mechanism and screening new antiemetic drugs. |
| doi_str_mv | 10.3748/wjg.v12.i8.1300 |
| format | Article |
| fullrecord | <record><control><sourceid>wanfang_jour_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4124448</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>21533187</cqvip_id><wanfj_id>wjg200608025</wanfj_id><sourcerecordid>wjg200608025</sourcerecordid><originalsourceid>FETCH-LOGICAL-c447t-938c90796398b7862925304cb19c6d1dc2c92b994f4fe3c207b7ef0b2063fb7f3</originalsourceid><addsrcrecordid>eNpVkc1P3DAQxa2qqGy3PfeGogr1lt3xR2L7goRQW5CQuNBeLcexs14SG-JkEf89Xu2qhdMc5s1v3sxD6BuGFeVMrJ-33WqHycqLFaYAH9CCECxLIhh8RAsMwEtJCT9Fn1PaAhBKK_IJneK6okxIWCD-V_ezLaIrBh8eil0c_FQMsbV94UORprl92Td1mHxpBzt5U7Tj3KUv6MTpPtmvx7pEf379vL-6Lm_vft9cXd6WhjE-5eXCSOCyplI0XNREkooCMw2Wpm5xa4iRpJGSOeYsNQR4w62DhkBNXcMdXaKLA_dxbgbbGhumUffqcfSDHl9U1F697wS_UV3cKYYJY0xkwPkB8KyD06FT2ziPIVtW-XcEoAYB2dMS_TjuGePTbNOkBp-M7XsdbJyTqjlnklU4C9cHoRljSqN1_7xgUPtM9lyVM1FeqH0meeLs7Qn_9ccQsuD7EbmJoXvy2WSjzYPzvVUEV5RiwekrdpGTLg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67749451</pqid></control><display><type>article</type><title>Value of mink vomit model in study of anti-emetic drugs</title><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Zhang, Fang ; Wang, Lei ; Yang, Zhi-Hong ; Liu, Zhan-Tao ; Yue, Wang</creator><creatorcontrib>Zhang, Fang ; Wang, Lei ; Yang, Zhi-Hong ; Liu, Zhan-Tao ; Yue, Wang</creatorcontrib><description>AIM： To establish a new, reliable vomit model of minks
METHODS： Adult male minks were randomly divided into 8 groups （n=6）： cisplatin （7.5 mg/kg） intraperitoneal injection （ip） group, copper sulfate （40 mg/kg） intragastric injection （ig） group, apomorphine （1.6 mg/kg） subcutaneous injection （sc） group, and 18 Gy whole-body X-irradiation group, ondansetron injection group （2 mg/kg ip） 30 min later followed by cisplatin （7.5 mg/kg） ip, normal saline （NS） ip injection control group, metoclopramide injection group （4 mg/kg ip） 30 rain later followed by apomorphine （1.6 mg/kg） sc, NS ig control group. The frequency of retching and vomiting was calculated. After behavioral experiment, distribution of 5-HT in the ileum was detected by immunohistologic method. RESULTS： Cisplatin, apomorphine, copper sulfate and X-irradiation administered to minks evoked a profound emetic response in the animals. However, retching and vomiting were significantly inhibited by pretreatment with ondansetron and metoclopramide in cisplatin and copper sulfate groups （P=0.018）. Immunohistologic result showed that 5-HT released from enterochromaffin cells （EC cells） was involved in vomiting mechanism.
CONCLUSION： Mink vomit model has a great value in studying the vomiting mechanism and screening new antiemetic drugs.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v12.i8.1300</identifier><identifier>PMID: 16534890</identifier><language>eng</language><publisher>United States: Department of Pharmacology, Medical College of Qingdao University, Qingdao 266021, Shandong Province, China</publisher><subject>Animals ; Antiemetics - therapeutic use ; Apomorphine ; Cisplatin - administration & dosage ; Copper Sulfate - administration & dosage ; Disease Models, Animal ; Enterochromaffin Cells - metabolism ; Immunohistochemistry ; Male ; Metoclopramide - administration & dosage ; Metoclopramide - therapeutic use ; Mink ; Ondansetron - administration & dosage ; Ondansetron - therapeutic use ; Random Allocation ; Rapid Communication ; Reproducibility of Results ; Serotonin - metabolism ; Vomiting - chemically induced ; Vomiting - physiopathology ; Vomiting - prevention & control ; 动物实验 ; 止呕药</subject><ispartof>World journal of gastroenterology : WJG, 2006-02, Vol.12 (8), p.1300-1302</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2006 Baishideng Publishing Group Co., Limited. All rights reserved. 2006</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-938c90796398b7862925304cb19c6d1dc2c92b994f4fe3c207b7ef0b2063fb7f3</citedby><cites>FETCH-LOGICAL-c447t-938c90796398b7862925304cb19c6d1dc2c92b994f4fe3c207b7ef0b2063fb7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124448/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124448/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16534890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Fang</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Yang, Zhi-Hong</creatorcontrib><creatorcontrib>Liu, Zhan-Tao</creatorcontrib><creatorcontrib>Yue, Wang</creatorcontrib><title>Value of mink vomit model in study of anti-emetic drugs</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM： To establish a new, reliable vomit model of minks
METHODS： Adult male minks were randomly divided into 8 groups （n=6）： cisplatin （7.5 mg/kg） intraperitoneal injection （ip） group, copper sulfate （40 mg/kg） intragastric injection （ig） group, apomorphine （1.6 mg/kg） subcutaneous injection （sc） group, and 18 Gy whole-body X-irradiation group, ondansetron injection group （2 mg/kg ip） 30 min later followed by cisplatin （7.5 mg/kg） ip, normal saline （NS） ip injection control group, metoclopramide injection group （4 mg/kg ip） 30 rain later followed by apomorphine （1.6 mg/kg） sc, NS ig control group. The frequency of retching and vomiting was calculated. After behavioral experiment, distribution of 5-HT in the ileum was detected by immunohistologic method. RESULTS： Cisplatin, apomorphine, copper sulfate and X-irradiation administered to minks evoked a profound emetic response in the animals. However, retching and vomiting were significantly inhibited by pretreatment with ondansetron and metoclopramide in cisplatin and copper sulfate groups （P=0.018）. Immunohistologic result showed that 5-HT released from enterochromaffin cells （EC cells） was involved in vomiting mechanism.
CONCLUSION： Mink vomit model has a great value in studying the vomiting mechanism and screening new antiemetic drugs.</description><subject>Animals</subject><subject>Antiemetics - therapeutic use</subject><subject>Apomorphine</subject><subject>Cisplatin - administration & dosage</subject><subject>Copper Sulfate - administration & dosage</subject><subject>Disease Models, Animal</subject><subject>Enterochromaffin Cells - metabolism</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Metoclopramide - administration & dosage</subject><subject>Metoclopramide - therapeutic use</subject><subject>Mink</subject><subject>Ondansetron - administration & dosage</subject><subject>Ondansetron - therapeutic use</subject><subject>Random Allocation</subject><subject>Rapid Communication</subject><subject>Reproducibility of Results</subject><subject>Serotonin - metabolism</subject><subject>Vomiting - chemically induced</subject><subject>Vomiting - physiopathology</subject><subject>Vomiting - prevention & control</subject><subject>动物实验</subject><subject>止呕药</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1P3DAQxa2qqGy3PfeGogr1lt3xR2L7goRQW5CQuNBeLcexs14SG-JkEf89Xu2qhdMc5s1v3sxD6BuGFeVMrJ-33WqHycqLFaYAH9CCECxLIhh8RAsMwEtJCT9Fn1PaAhBKK_IJneK6okxIWCD-V_ezLaIrBh8eil0c_FQMsbV94UORprl92Td1mHxpBzt5U7Tj3KUv6MTpPtmvx7pEf379vL-6Lm_vft9cXd6WhjE-5eXCSOCyplI0XNREkooCMw2Wpm5xa4iRpJGSOeYsNQR4w62DhkBNXcMdXaKLA_dxbgbbGhumUffqcfSDHl9U1F697wS_UV3cKYYJY0xkwPkB8KyD06FT2ziPIVtW-XcEoAYB2dMS_TjuGePTbNOkBp-M7XsdbJyTqjlnklU4C9cHoRljSqN1_7xgUPtM9lyVM1FeqH0meeLs7Qn_9ccQsuD7EbmJoXvy2WSjzYPzvVUEV5RiwekrdpGTLg</recordid><startdate>20060228</startdate><enddate>20060228</enddate><creator>Zhang, Fang</creator><creator>Wang, Lei</creator><creator>Yang, Zhi-Hong</creator><creator>Liu, Zhan-Tao</creator><creator>Yue, Wang</creator><general>Department of Pharmacology, Medical College of Qingdao University, Qingdao 266021, Shandong Province, China</general><general>Baishideng Publishing Group Co., Limited</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20060228</creationdate><title>Value of mink vomit model in study of anti-emetic drugs</title><author>Zhang, Fang ; Wang, Lei ; Yang, Zhi-Hong ; Liu, Zhan-Tao ; Yue, Wang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-938c90796398b7862925304cb19c6d1dc2c92b994f4fe3c207b7ef0b2063fb7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Antiemetics - therapeutic use</topic><topic>Apomorphine</topic><topic>Cisplatin - administration & dosage</topic><topic>Copper Sulfate - administration & dosage</topic><topic>Disease Models, Animal</topic><topic>Enterochromaffin Cells - metabolism</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Metoclopramide - administration & dosage</topic><topic>Metoclopramide - therapeutic use</topic><topic>Mink</topic><topic>Ondansetron - administration & dosage</topic><topic>Ondansetron - therapeutic use</topic><topic>Random Allocation</topic><topic>Rapid Communication</topic><topic>Reproducibility of Results</topic><topic>Serotonin - metabolism</topic><topic>Vomiting - chemically induced</topic><topic>Vomiting - physiopathology</topic><topic>Vomiting - prevention & control</topic><topic>动物实验</topic><topic>止呕药</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Fang</creatorcontrib><creatorcontrib>Wang, Lei</creatorcontrib><creatorcontrib>Yang, Zhi-Hong</creatorcontrib><creatorcontrib>Liu, Zhan-Tao</creatorcontrib><creatorcontrib>Yue, Wang</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Fang</au><au>Wang, Lei</au><au>Yang, Zhi-Hong</au><au>Liu, Zhan-Tao</au><au>Yue, Wang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of mink vomit model in study of anti-emetic drugs</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2006-02-28</date><risdate>2006</risdate><volume>12</volume><issue>8</issue><spage>1300</spage><epage>1302</epage><pages>1300-1302</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM： To establish a new, reliable vomit model of minks
METHODS： Adult male minks were randomly divided into 8 groups （n=6）： cisplatin （7.5 mg/kg） intraperitoneal injection （ip） group, copper sulfate （40 mg/kg） intragastric injection （ig） group, apomorphine （1.6 mg/kg） subcutaneous injection （sc） group, and 18 Gy whole-body X-irradiation group, ondansetron injection group （2 mg/kg ip） 30 min later followed by cisplatin （7.5 mg/kg） ip, normal saline （NS） ip injection control group, metoclopramide injection group （4 mg/kg ip） 30 rain later followed by apomorphine （1.6 mg/kg） sc, NS ig control group. The frequency of retching and vomiting was calculated. After behavioral experiment, distribution of 5-HT in the ileum was detected by immunohistologic method. RESULTS： Cisplatin, apomorphine, copper sulfate and X-irradiation administered to minks evoked a profound emetic response in the animals. However, retching and vomiting were significantly inhibited by pretreatment with ondansetron and metoclopramide in cisplatin and copper sulfate groups （P=0.018）. Immunohistologic result showed that 5-HT released from enterochromaffin cells （EC cells） was involved in vomiting mechanism.
CONCLUSION： Mink vomit model has a great value in studying the vomiting mechanism and screening new antiemetic drugs.</abstract><cop>United States</cop><pub>Department of Pharmacology, Medical College of Qingdao University, Qingdao 266021, Shandong Province, China</pub><pmid>16534890</pmid><doi>10.3748/wjg.v12.i8.1300</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antiemetics - therapeutic use Apomorphine Cisplatin - administration & dosage Copper Sulfate - administration & dosage Disease Models, Animal Enterochromaffin Cells - metabolism Immunohistochemistry Male Metoclopramide - administration & dosage Metoclopramide - therapeutic use Mink Ondansetron - administration & dosage Ondansetron - therapeutic use Random Allocation Rapid Communication Reproducibility of Results Serotonin - metabolism Vomiting - chemically induced Vomiting - physiopathology Vomiting - prevention & control 动物实验 止呕药 |
| title | Value of mink vomit model in study of anti-emetic drugs |
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