let‐7e replacement yields potent anti‐arrhythmic efficacy via targeting beta 1‐adrenergic receptor in rat heart

Beta‐adrenoceptor (β‐AR) exerts critical regulation of cardiac function. MicroRNAs (miRNAs) are potentially involved in a variety of biological and pathological processes. This study aimed to investigate the role of miRNA let‐7e in the up‐regulation of β1‐AR and arrhythmogenesis in acute myocardial...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2014-07, Vol.18 (7), p.1334-1343
Hauptverfasser:	Li, Xin, Wang, Baoqiu, Cui, Hairong, Du, Yue, Song, Yang, Yang, Lei, Zhang, Qi, Sun, Fei, Luo, Dan, Xu, Chaoqian, Chu, Wenfeng, Lu, Yanjie, Yang, Baofeng
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics acute myocardial infarction Adrenergic receptors Animals Anti-Arrhythmia Agents Antisense therapy anti‐arrhythmia Arrhythmia Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - pathology Arrhythmias, Cardiac - prevention & control Biomarkers - analysis Blotting, Western Cardiac arrhythmia Cardiac function Cells, Cultured Coronary vessels Gene expression Gene Expression Profiling Gene Expression Regulation Heart attacks Heart failure Heart Rate Ischemia Kinases let‐7e Male Metoprolol MicroRNAs MicroRNAs - genetics miRNA mRNA Myocardial infarction Myocardial Infarction - genetics Myocardial Infarction - pathology Myocardial Infarction - prevention & control Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Neonates Original Propranolol Proteins Rats Rats, Wistar Real-Time Polymerase Chain Reaction Receptors, Adrenergic, beta-1 - chemistry Receptors, Adrenergic, beta-1 - genetics Receptors, Adrenergic, beta-1 - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Ventricle β1‐AR
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