Association between genetic polymorphisms of cytochrome P450 2C19 and the risk of cerebral ischemic stroke in Chinese
Cytochrome P450 (CYP) 2C19 is a very important drug metabolizing enzyme. Although the single nucleotide polymorphisms (SNPs) of CYP2C19 G681A and G636A have been suggested that they may increase the incidence of cardiovascular events, the relationship between SNPs in CYP2C19 and cerebral ischemic st...
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| Veröffentlicht in: | BMC genetics 2014-07, Vol.15 (1), p.83-83, Article 83 |
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| creator | Gu, Shuzhen Sun, Yan Han, Ruifa Wang, Lin Wang, Dongliang Wang, Jizuo Li, Xin |
| description | Cytochrome P450 (CYP) 2C19 is a very important drug metabolizing enzyme. Although the single nucleotide polymorphisms (SNPs) of CYP2C19 G681A and G636A have been suggested that they may increase the incidence of cardiovascular events, the relationship between SNPs in CYP2C19 and cerebral ischemic stroke (CIS) are unclear. The aim of this study was to investigate the correlation between the distribution of G681A and G636A polymorphisms in CYP2C19 gene and the risk of CIS in Chinese.
The peripheral blood DNA was extracted from 299 patients with CIS and 295 healthy controls. The genotyping was conducted using the polymerase chain reaction-restriction fragment length polymorphism. The sampled sequencing was applied to verify the correctness of genotyping results. Both the genotype and allele distributions were compared in patients with CIS and healthy controls.
The frequencies of CYP2C19 681AA (11.7% vs. 2.7%; P = 0.000), 636AA (4.0% vs. 0.7%; P = 0.007), 636AG (7.0% vs. 2.2%; P = 0.038) genotype, CYP2C19 681A (30.9% vs. 20.8%; P = 0.000) and 636A (13.0% vs. 5.8%; P = 0.000) allele in the CIS group are significantly higher than those in the controls. The frequencies of CYP2C19 681AA (16.7% vs. 8.6%; P = 0.036), CYP2C19 636AA (7.0% vs. 2.2%; P = 0.038) genotype, CYP2C19 681A (36.4% vs. 27.6%; P = 0.023) and CYP2C19 636A (17.5% vs.10.3%; P = 0.010) allele in the recurrent stroke group are significantly higher than those in the first onset group. Multivariate logistic regression analysis of risk factors for cerebral ischemic stroke and recurrent stroke respectively suggests that the CYP2C19 681AA genotype may be an independent risk factor for CIS (OR = 6.179, 95% CI: 2.285 ~ 16.708; P = 0.000) and recurrent stroke (OR = 2.305, 95% CI: 1.121 ~ 4.743; P = 0.023).
The AA genotype and A allele of CYP2C19 G681A may be related to the occurrence and recurrence of cerebral ischemic stroke. |
| doi_str_mv | 10.1186/1471-2350-15-83 |
| format | Article |
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The peripheral blood DNA was extracted from 299 patients with CIS and 295 healthy controls. The genotyping was conducted using the polymerase chain reaction-restriction fragment length polymorphism. The sampled sequencing was applied to verify the correctness of genotyping results. Both the genotype and allele distributions were compared in patients with CIS and healthy controls.
The frequencies of CYP2C19 681AA (11.7% vs. 2.7%; P = 0.000), 636AA (4.0% vs. 0.7%; P = 0.007), 636AG (7.0% vs. 2.2%; P = 0.038) genotype, CYP2C19 681A (30.9% vs. 20.8%; P = 0.000) and 636A (13.0% vs. 5.8%; P = 0.000) allele in the CIS group are significantly higher than those in the controls. The frequencies of CYP2C19 681AA (16.7% vs. 8.6%; P = 0.036), CYP2C19 636AA (7.0% vs. 2.2%; P = 0.038) genotype, CYP2C19 681A (36.4% vs. 27.6%; P = 0.023) and CYP2C19 636A (17.5% vs.10.3%; P = 0.010) allele in the recurrent stroke group are significantly higher than those in the first onset group. Multivariate logistic regression analysis of risk factors for cerebral ischemic stroke and recurrent stroke respectively suggests that the CYP2C19 681AA genotype may be an independent risk factor for CIS (OR = 6.179, 95% CI: 2.285 ~ 16.708; P = 0.000) and recurrent stroke (OR = 2.305, 95% CI: 1.121 ~ 4.743; P = 0.023).
The AA genotype and A allele of CYP2C19 G681A may be related to the occurrence and recurrence of cerebral ischemic stroke.</description><identifier>ISSN: 1471-2350</identifier><identifier>ISSN: 1471-2156</identifier><identifier>EISSN: 1471-2350</identifier><identifier>EISSN: 1471-2156</identifier><identifier>DOI: 10.1186/1471-2350-15-83</identifier><identifier>PMID: 25030528</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Aged ; Aryl Hydrocarbon Hydroxylases - genetics ; Asian Continental Ancestry Group - genetics ; Brain Ischemia - genetics ; Cardiovascular disease ; Case-Control Studies ; Cytochrome P-450 CYP2C19 ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Medical research ; Middle Aged ; Multivariate Analysis ; NMR ; Nuclear magnetic resonance ; Polymorphism, Single Nucleotide ; Recurrence ; Risk Factors ; Sequence Analysis, DNA ; Stroke ; Stroke - genetics ; Studies</subject><ispartof>BMC genetics, 2014-07, Vol.15 (1), p.83-83, Article 83</ispartof><rights>2014 Gu et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>Copyright © 2014 Gu et al.; licensee BioMed Central Ltd. 2014 Gu et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b583t-1d1c0b8e8029a9a4fad7844882137942aaf9d0fdec4a79216e2c77aa180337b13</citedby><cites>FETCH-LOGICAL-b583t-1d1c0b8e8029a9a4fad7844882137942aaf9d0fdec4a79216e2c77aa180337b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123826/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123826/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25030528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gu, Shuzhen</creatorcontrib><creatorcontrib>Sun, Yan</creatorcontrib><creatorcontrib>Han, Ruifa</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><creatorcontrib>Wang, Dongliang</creatorcontrib><creatorcontrib>Wang, Jizuo</creatorcontrib><creatorcontrib>Li, Xin</creatorcontrib><title>Association between genetic polymorphisms of cytochrome P450 2C19 and the risk of cerebral ischemic stroke in Chinese</title><title>BMC genetics</title><addtitle>BMC Med Genet</addtitle><description>Cytochrome P450 (CYP) 2C19 is a very important drug metabolizing enzyme. Although the single nucleotide polymorphisms (SNPs) of CYP2C19 G681A and G636A have been suggested that they may increase the incidence of cardiovascular events, the relationship between SNPs in CYP2C19 and cerebral ischemic stroke (CIS) are unclear. The aim of this study was to investigate the correlation between the distribution of G681A and G636A polymorphisms in CYP2C19 gene and the risk of CIS in Chinese.
The peripheral blood DNA was extracted from 299 patients with CIS and 295 healthy controls. The genotyping was conducted using the polymerase chain reaction-restriction fragment length polymorphism. The sampled sequencing was applied to verify the correctness of genotyping results. Both the genotype and allele distributions were compared in patients with CIS and healthy controls.
The frequencies of CYP2C19 681AA (11.7% vs. 2.7%; P = 0.000), 636AA (4.0% vs. 0.7%; P = 0.007), 636AG (7.0% vs. 2.2%; P = 0.038) genotype, CYP2C19 681A (30.9% vs. 20.8%; P = 0.000) and 636A (13.0% vs. 5.8%; P = 0.000) allele in the CIS group are significantly higher than those in the controls. The frequencies of CYP2C19 681AA (16.7% vs. 8.6%; P = 0.036), CYP2C19 636AA (7.0% vs. 2.2%; P = 0.038) genotype, CYP2C19 681A (36.4% vs. 27.6%; P = 0.023) and CYP2C19 636A (17.5% vs.10.3%; P = 0.010) allele in the recurrent stroke group are significantly higher than those in the first onset group. Multivariate logistic regression analysis of risk factors for cerebral ischemic stroke and recurrent stroke respectively suggests that the CYP2C19 681AA genotype may be an independent risk factor for CIS (OR = 6.179, 95% CI: 2.285 ~ 16.708; P = 0.000) and recurrent stroke (OR = 2.305, 95% CI: 1.121 ~ 4.743; P = 0.023).
The AA genotype and A allele of CYP2C19 G681A may be related to the occurrence and recurrence of cerebral ischemic stroke.</description><subject>Aged</subject><subject>Aryl Hydrocarbon Hydroxylases - genetics</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Brain Ischemia - genetics</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Cytochrome P-450 CYP2C19</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Recurrence</subject><subject>Risk Factors</subject><subject>Sequence Analysis, DNA</subject><subject>Stroke</subject><subject>Stroke - genetics</subject><subject>Studies</subject><issn>1471-2350</issn><issn>1471-2156</issn><issn>1471-2350</issn><issn>1471-2156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkk1v1DAURS1ERcvAmh2yxIZNqJ_tJM4GqR3xJVUqC1hbjvPSuE3swU5A8-_xMGXUViB1Zcvv-Or6yIS8AvYOQFWnIGsouChZAWWhxBNycjh5emd_TJ6ndM0Y1EqIZ-SYl0ywkqsTspylFKwzswuetjj_QvT0Cj3OztJNGLdTiJvBpSnR0FO7nYMdYpiQfpUlo3wNDTW-o_OANLp08wfCiG00I3XJDjjlnDTHcIPUeboenMeEL8hRb8aEL2_XFfn-8cO39efi4vLTl_XZRdGWSswFdGBZq1Ax3pjGyN50tZJSKQ6ibiQ3pm861ndopakbDhVyW9fGgGJC1C2IFXm_z90s7YSdRT_nYnoT3WTiVgfj9P2Jd4O-Cj-1BC4Ur3LA-T6gdeE_AfcnNkx6p13vtGsodRa-Im9vW8TwY8E06ymrwXE0HsOSMlUxyJc4ewRaclHlt8qMvnmAXocl-qxzR0Fdclk1mTrdUzaGlCL2h-6Q6-Uv9I-2r-86O_B__4z4Db1LwZc</recordid><startdate>20140717</startdate><enddate>20140717</enddate><creator>Gu, Shuzhen</creator><creator>Sun, Yan</creator><creator>Han, Ruifa</creator><creator>Wang, Lin</creator><creator>Wang, Dongliang</creator><creator>Wang, Jizuo</creator><creator>Li, Xin</creator><general>BioMed Central</general><general>BioMed Central Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140717</creationdate><title>Association between genetic polymorphisms of cytochrome P450 2C19 and the risk of cerebral ischemic stroke in Chinese</title><author>Gu, Shuzhen ; Sun, Yan ; Han, Ruifa ; Wang, Lin ; Wang, Dongliang ; Wang, Jizuo ; Li, Xin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b583t-1d1c0b8e8029a9a4fad7844882137942aaf9d0fdec4a79216e2c77aa180337b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Aryl Hydrocarbon Hydroxylases - genetics</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Brain Ischemia - genetics</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Cytochrome P-450 CYP2C19</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Recurrence</topic><topic>Risk Factors</topic><topic>Sequence Analysis, DNA</topic><topic>Stroke</topic><topic>Stroke - genetics</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gu, Shuzhen</creatorcontrib><creatorcontrib>Sun, Yan</creatorcontrib><creatorcontrib>Han, Ruifa</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><creatorcontrib>Wang, Dongliang</creatorcontrib><creatorcontrib>Wang, Jizuo</creatorcontrib><creatorcontrib>Li, Xin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gu, Shuzhen</au><au>Sun, Yan</au><au>Han, Ruifa</au><au>Wang, Lin</au><au>Wang, Dongliang</au><au>Wang, Jizuo</au><au>Li, Xin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between genetic polymorphisms of cytochrome P450 2C19 and the risk of cerebral ischemic stroke in Chinese</atitle><jtitle>BMC genetics</jtitle><addtitle>BMC Med Genet</addtitle><date>2014-07-17</date><risdate>2014</risdate><volume>15</volume><issue>1</issue><spage>83</spage><epage>83</epage><pages>83-83</pages><artnum>83</artnum><issn>1471-2350</issn><issn>1471-2156</issn><eissn>1471-2350</eissn><eissn>1471-2156</eissn><abstract>Cytochrome P450 (CYP) 2C19 is a very important drug metabolizing enzyme. Although the single nucleotide polymorphisms (SNPs) of CYP2C19 G681A and G636A have been suggested that they may increase the incidence of cardiovascular events, the relationship between SNPs in CYP2C19 and cerebral ischemic stroke (CIS) are unclear. The aim of this study was to investigate the correlation between the distribution of G681A and G636A polymorphisms in CYP2C19 gene and the risk of CIS in Chinese.
The peripheral blood DNA was extracted from 299 patients with CIS and 295 healthy controls. The genotyping was conducted using the polymerase chain reaction-restriction fragment length polymorphism. The sampled sequencing was applied to verify the correctness of genotyping results. Both the genotype and allele distributions were compared in patients with CIS and healthy controls.
The frequencies of CYP2C19 681AA (11.7% vs. 2.7%; P = 0.000), 636AA (4.0% vs. 0.7%; P = 0.007), 636AG (7.0% vs. 2.2%; P = 0.038) genotype, CYP2C19 681A (30.9% vs. 20.8%; P = 0.000) and 636A (13.0% vs. 5.8%; P = 0.000) allele in the CIS group are significantly higher than those in the controls. The frequencies of CYP2C19 681AA (16.7% vs. 8.6%; P = 0.036), CYP2C19 636AA (7.0% vs. 2.2%; P = 0.038) genotype, CYP2C19 681A (36.4% vs. 27.6%; P = 0.023) and CYP2C19 636A (17.5% vs.10.3%; P = 0.010) allele in the recurrent stroke group are significantly higher than those in the first onset group. Multivariate logistic regression analysis of risk factors for cerebral ischemic stroke and recurrent stroke respectively suggests that the CYP2C19 681AA genotype may be an independent risk factor for CIS (OR = 6.179, 95% CI: 2.285 ~ 16.708; P = 0.000) and recurrent stroke (OR = 2.305, 95% CI: 1.121 ~ 4.743; P = 0.023).
The AA genotype and A allele of CYP2C19 G681A may be related to the occurrence and recurrence of cerebral ischemic stroke.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>25030528</pmid><doi>10.1186/1471-2350-15-83</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Springer Nature OA/Free Journals; PubMed Central Open Access |
| subjects | Aged Aryl Hydrocarbon Hydroxylases - genetics Asian Continental Ancestry Group - genetics Brain Ischemia - genetics Cardiovascular disease Case-Control Studies Cytochrome P-450 CYP2C19 Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Male Medical research Middle Aged Multivariate Analysis NMR Nuclear magnetic resonance Polymorphism, Single Nucleotide Recurrence Risk Factors Sequence Analysis, DNA Stroke Stroke - genetics Studies |
| title | Association between genetic polymorphisms of cytochrome P450 2C19 and the risk of cerebral ischemic stroke in Chinese |
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