Effect of Local Tidal Lung Strain on Inflammation in Normal and Lipopolysaccharide-Exposed Sheep

OBJECTIVES:Regional tidal lung strain may trigger local inflammation during mechanical ventilation, particularly when additional inflammatory stimuli are present. However, it is unclear whether inflammation develops proportionally to tidal strain or only above a threshold. We aimed to 1) assess the...

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Veröffentlicht in:	Critical care medicine 2014-07, Vol.42 (7), p.e491-e500
Hauptverfasser:	Wellman, Tyler J, Winkler, Tilo, Costa, Eduardo L V, Musch, Guido, Harris, R Scott, Zheng, Hui, Venegas, Jose G, Vidal Melo, Marcos F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - physiopathology Animals Disease Models, Animal Fluorodeoxyglucose F18 Inflammation - physiopathology Lipopolysaccharides Pneumonia - physiopathology Positive-Pressure Respiration Positron-Emission Tomography Radiopharmaceuticals Respiration, Artificial Respiratory Function Tests Sheep Tidal Volume
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