Current and Future Intraoperative Imaging Strategies to Increase Radical Resection Rates in Pancreatic Cancer Surgery
Prognosis of patients with pancreatic cancer is poor. Even the small minority that undergoes resection with curative intent has low 5-year survival rates. This may partly be explained by the high number of irradical resections, which results in local recurrence and impaired overall survival. Current...
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| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-8 |
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| creator | Handgraaf, Henricus J. M. Boonstra, Martin C. Van Erkel, Arian R. Bonsing, Bert A. Putter, Hein van de Velde, Cornelis J. H. Vahrmeijer, Alexander L. Mieog, J. Sven D. |
| description | Prognosis of patients with pancreatic cancer is poor. Even the small minority that undergoes resection with curative intent has low 5-year survival rates. This may partly be explained by the high number of irradical resections, which results in local recurrence and impaired overall survival. Currently, ultrasonography is used during surgery for resectability assessment and frozen-section analysis is used for assessment of resection margins in order to decrease the number of irradical resections. The introduction of minimal invasive techniques in pancreatic surgery has deprived surgeons from direct tactile information. To improve intraoperative assessment of pancreatic tumor extension, enhanced or novel intraoperative imaging technologies accurately visualizing and delineating cancer cells are necessary. Emerging modalities are intraoperative near-infrared fluorescence imaging and freehand nuclear imaging using tumor-specific targeted contrast agents. In this review, we performed a meta-analysis of the literature on laparoscopic ultrasonography and we summarized and discussed current and future intraoperative imaging modalities and their potential for improved tumor demarcation during pancreatic surgery. |
| doi_str_mv | 10.1155/2014/890230 |
| format | Article |
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M. ; Boonstra, Martin C. ; Van Erkel, Arian R. ; Bonsing, Bert A. ; Putter, Hein ; van de Velde, Cornelis J. H. ; Vahrmeijer, Alexander L. ; Mieog, J. Sven D.</creator><contributor>Hirota, Masahiko</contributor><creatorcontrib>Handgraaf, Henricus J. M. ; Boonstra, Martin C. ; Van Erkel, Arian R. ; Bonsing, Bert A. ; Putter, Hein ; van de Velde, Cornelis J. H. ; Vahrmeijer, Alexander L. ; Mieog, J. Sven D. ; Hirota, Masahiko</creatorcontrib><description>Prognosis of patients with pancreatic cancer is poor. Even the small minority that undergoes resection with curative intent has low 5-year survival rates. This may partly be explained by the high number of irradical resections, which results in local recurrence and impaired overall survival. Currently, ultrasonography is used during surgery for resectability assessment and frozen-section analysis is used for assessment of resection margins in order to decrease the number of irradical resections. The introduction of minimal invasive techniques in pancreatic surgery has deprived surgeons from direct tactile information. To improve intraoperative assessment of pancreatic tumor extension, enhanced or novel intraoperative imaging technologies accurately visualizing and delineating cancer cells are necessary. Emerging modalities are intraoperative near-infrared fluorescence imaging and freehand nuclear imaging using tumor-specific targeted contrast agents. In this review, we performed a meta-analysis of the literature on laparoscopic ultrasonography and we summarized and discussed current and future intraoperative imaging modalities and their potential for improved tumor demarcation during pancreatic surgery.</description><identifier>ISSN: 2314-6133</identifier><identifier>ISSN: 2314-6141</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/890230</identifier><identifier>PMID: 25157372</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Cancer surgery ; Care and treatment ; Diagnostic imaging ; Diagnostic Imaging - methods ; Distribution ; Excision (Surgery) ; Forecasts and trends ; Humans ; Intraoperative Care - methods ; Laparoscopy ; Medical imaging ; Metastasis ; Methods ; Mortality ; Pancreas ; Pancreatic cancer ; Pancreatic Neoplasms - diagnosis ; Pancreatic Neoplasms - diagnostic imaging ; Pancreatic Neoplasms - surgery ; Patients ; Radionuclide Imaging ; Review ; Tomography ; Ultrasonic imaging ; Ultrasonography</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-8</ispartof><rights>Copyright © 2014 Henricus J. M. Handgraaf et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Henricus J. M. Handgraaf et al. Henricus J. M. Handgraaf et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Henricus J. M. Handgraaf et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-5647ddcf5b0458ac46c2daa9e7841c0ce084e7b92ac3bd2954217b8ab159023d3</citedby><cites>FETCH-LOGICAL-c527t-5647ddcf5b0458ac46c2daa9e7841c0ce084e7b92ac3bd2954217b8ab159023d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123536/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123536/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25157372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hirota, Masahiko</contributor><creatorcontrib>Handgraaf, Henricus J. M.</creatorcontrib><creatorcontrib>Boonstra, Martin C.</creatorcontrib><creatorcontrib>Van Erkel, Arian R.</creatorcontrib><creatorcontrib>Bonsing, Bert A.</creatorcontrib><creatorcontrib>Putter, Hein</creatorcontrib><creatorcontrib>van de Velde, Cornelis J. H.</creatorcontrib><creatorcontrib>Vahrmeijer, Alexander L.</creatorcontrib><creatorcontrib>Mieog, J. Sven D.</creatorcontrib><title>Current and Future Intraoperative Imaging Strategies to Increase Radical Resection Rates in Pancreatic Cancer Surgery</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Prognosis of patients with pancreatic cancer is poor. Even the small minority that undergoes resection with curative intent has low 5-year survival rates. This may partly be explained by the high number of irradical resections, which results in local recurrence and impaired overall survival. 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In this review, we performed a meta-analysis of the literature on laparoscopic ultrasonography and we summarized and discussed current and future intraoperative imaging modalities and their potential for improved tumor demarcation during pancreatic surgery.</description><subject>Cancer surgery</subject><subject>Care and treatment</subject><subject>Diagnostic imaging</subject><subject>Diagnostic Imaging - methods</subject><subject>Distribution</subject><subject>Excision (Surgery)</subject><subject>Forecasts and trends</subject><subject>Humans</subject><subject>Intraoperative Care - methods</subject><subject>Laparoscopy</subject><subject>Medical imaging</subject><subject>Metastasis</subject><subject>Methods</subject><subject>Mortality</subject><subject>Pancreas</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - diagnosis</subject><subject>Pancreatic Neoplasms - diagnostic imaging</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Patients</subject><subject>Radionuclide Imaging</subject><subject>Review</subject><subject>Tomography</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><issn>2314-6133</issn><issn>2314-6141</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0t1r1TAYBvAiihtzV14rAW9EOS6fTXojjIPTwUDZ9Dq8Td_TZfSkxySd7L83tfP4cbPeNE1_PCQPb1U9Z_QdY0qdcMrkiWkoF_RRdcgFk6uaSfZ4vxbioDpO6YaWx7CaNvXT6oArprTQ_LCa1lOMGDKB0JGzKU8RyXnIEcYdRsj-tnxuofehJ1dlN2PvMZE8FuQiQkJyCZ13MJBLTOiyH0PZycX4QL7AL5S9I-uyxEiupthjvHtWPdnAkPD4_n1UfTv78HX9aXXx-eP5-vRi5RTXeaVqqbvObVRLpTLgZO14B9CgNpI56pAaibptODjRdrxRkjPdGmiZmhvpxFH1fsndTe0WO4fzzQa7i34L8c6O4O2_f4K_tv14ayXjQom6BLy-D4jj9wlTtlufHA4DBBynZFnNSqlMGPUwVaa0b4Rihb76j96MUwyliaIUN1KzWvxRPQxofdiM5YhuDrWnkmvKpRG0qLeLcnFMKeJmfztG7Twidh4Ru4xI0S__LmRvfw9EAW8WcO1DBz_8A2kvFoyF4Ab2WFFVN1r8BKPZzAI</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Handgraaf, Henricus J. 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M.</au><au>Boonstra, Martin C.</au><au>Van Erkel, Arian R.</au><au>Bonsing, Bert A.</au><au>Putter, Hein</au><au>van de Velde, Cornelis J. H.</au><au>Vahrmeijer, Alexander L.</au><au>Mieog, J. Sven D.</au><au>Hirota, Masahiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Current and Future Intraoperative Imaging Strategies to Increase Radical Resection Rates in Pancreatic Cancer Surgery</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>2314-6133</issn><issn>2314-6141</issn><eissn>2314-6141</eissn><abstract>Prognosis of patients with pancreatic cancer is poor. Even the small minority that undergoes resection with curative intent has low 5-year survival rates. This may partly be explained by the high number of irradical resections, which results in local recurrence and impaired overall survival. Currently, ultrasonography is used during surgery for resectability assessment and frozen-section analysis is used for assessment of resection margins in order to decrease the number of irradical resections. The introduction of minimal invasive techniques in pancreatic surgery has deprived surgeons from direct tactile information. To improve intraoperative assessment of pancreatic tumor extension, enhanced or novel intraoperative imaging technologies accurately visualizing and delineating cancer cells are necessary. Emerging modalities are intraoperative near-infrared fluorescence imaging and freehand nuclear imaging using tumor-specific targeted contrast agents. In this review, we performed a meta-analysis of the literature on laparoscopic ultrasonography and we summarized and discussed current and future intraoperative imaging modalities and their potential for improved tumor demarcation during pancreatic surgery.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>25157372</pmid><doi>10.1155/2014/890230</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Cancer surgery Care and treatment Diagnostic imaging Diagnostic Imaging - methods Distribution Excision (Surgery) Forecasts and trends Humans Intraoperative Care - methods Laparoscopy Medical imaging Metastasis Methods Mortality Pancreas Pancreatic cancer Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - diagnostic imaging Pancreatic Neoplasms - surgery Patients Radionuclide Imaging Review Tomography Ultrasonic imaging Ultrasonography |
| title | Current and Future Intraoperative Imaging Strategies to Increase Radical Resection Rates in Pancreatic Cancer Surgery |
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