Hallmarks of triple negative breast cancer emerging at last

Triple negative breast cancers （TNBC） are clinically heterogeneous but mostly aggressive malignancies devoid of expression of the estrogen, progesterone and HER2 （ERBB2 or NEU） receptors. Recent evidence shows that basal endoplasmic reticulum stress （ERS） is typically activated in TNBC and cooperate...

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Veröffentlicht in:	Cell research 2014-08, Vol.24 (8), p.904-905
Hauptverfasser:	Bernardi, Rosa, Gianni, Luca
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337 631/67/1347 Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors Basic Helix-Loop-Helix Transcription Factors - metabolism Breast cancer Cell Biology DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism Endoplasmic Reticulum Stress ERBB2 ERS Estrogens Female Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Life Sciences Neoplastic Stem Cells - metabolism Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Recurrence Regulatory Factor X Transcription Factors Research Highlight Transcription Factors - antagonists & inhibitors Transcription Factors - metabolism Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Unfolded Protein Response 乳腺癌内质网应激异质性恶性肿瘤阴性雌激素
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Beschreibung
Zusammenfassung:	Triple negative breast cancers （TNBC） are clinically heterogeneous but mostly aggressive malignancies devoid of expression of the estrogen, progesterone and HER2 （ERBB2 or NEU） receptors. Recent evidence shows that basal endoplasmic reticulum stress （ERS） is typically activated in TNBC and cooperates with hypoxia signaling to promote tumor progression and relapse; ERS and hypoxia response may therefore be among the long-searched hallmarks of TNBC.
ISSN:	1001-0602 1748-7838
DOI:	10.1038/cr.2014.61