Humanized mice as a model for aberrant responses in human T cell immunotherapy

Immune-deficient mice, reconstituted with human stem cells, have been used to analyze human immune responses in vivo. Although they have been used to study immune responses to xenografts, allografts, and pathogens, there have not been models of autoimmune disease in which the mechanisms of the patho...

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Veröffentlicht in:	The Journal of immunology (1950) 2014-07, Vol.193 (2), p.587-596
Hauptverfasser:	Vudattu, Nalini K, Waldron-Lynch, Frank, Truman, Lucy A, Deng, Songyan, Preston-Hurlburt, Paula, Torres, Richard, Raycroft, Maurice T, Mamula, Mark J, Herold, Kevan C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - drug effects Adrenal Glands - immunology Adrenal Glands - metabolism Animals Antibodies, Monoclonal - toxicity Antibodies, Monoclonal, Humanized - pharmacology Autoimmune Diseases - chemically induced Autoimmune Diseases - immunology Autoimmune Diseases - therapy Cytokines - blood Cytokines - immunology Cytokines - metabolism Disease Models, Animal Flow Cytometry Humans Interleukin Receptor Common gamma Subunit - deficiency Interleukin Receptor Common gamma Subunit - genetics Ipilimumab Liver - drug effects Liver - immunology Liver - metabolism Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Mice Mice, Inbred NOD Mice, Knockout Mice, SCID Phosphorylation - drug effects Phosphorylation - immunology STAT5 Transcription Factor - immunology STAT5 Transcription Factor - metabolism Stem Cell Transplantation - methods Survival Analysis T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Transplantation, Heterologous Weight Loss - drug effects Weight Loss - immunology
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