A metabolomic comparison of mouse models of the Neuronal Ceroid Lipofuscinoses

The Neuronal Ceroid Lipofuscinoses (NCL) are a group of fatal inherited neurodegenerative diseases in humans distinguished by a common clinical pathology, characterized by the accumulation of storage body material in cells and gross brain atrophy. In this study, metabolic changes in three NCL mouse...

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Veröffentlicht in:	Journal of biomolecular NMR 2011-04, Vol.49 (3-4), p.175-184
Hauptverfasser:	Salek, Reza M., Pears, Michael R., Cooper, Jonathan D., Mitchison, Hannah M., Pearce, David A., Mortishire-Smith, Russell J., Griffin, Julian L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescence Age Animal models Animals Atrophy Biochemistry Biological and Medical Physics Biophysics Brain Butyric acid Cerebellum Cerebellum - metabolism Cerebellum - pathology Cerebral Cortex - metabolism Cerebral Cortex - pathology Cortex Cortex (motor) Disease Models, Animal gamma -Aminobutyric acid Glutamic acid Glutamic Acid - metabolism Glutamine Glutamine - metabolism Magnetic Resonance Spectroscopy Metabolism metabolomics Mice Motor neuron disease Motor neurons N.M.R Neurodegeneration Neurodegenerative diseases Neuronal ceroid lipofuscinosis Neuronal Ceroid-Lipofuscinoses - metabolism Neuronal Ceroid-Lipofuscinoses - pathology Neurons - metabolism Neurons - pathology Physics Physics and Astronomy Pigments, Biological Spectroscopy/Spectrometry
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