Targeted next generation sequencing identifies clinically actionable mutations in patients with melanoma

Summary Somatic sequencing of cancers has produced new insight into tumorigenesis, tumor heterogeneity, and disease progression, but the vast majority of genetic events identified are of indeterminate clinical significance. Here, we describe a NextGen sequencing approach to fully analyzing 248 genes...

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Veröffentlicht in:	Pigment cell and melanoma research 2014-07, Vol.27 (4), p.653-663
Hauptverfasser:	Jeck, William R., Parker, Joel, Carson, Craig C., Shields, Janiel M., Sambade, Maria J., Peters, Eldon C., Burd, Christin E., Thomas, Nancy E., Chiang, Derek Y., Liu, Wenjin, Eberhard, David A., Ollila, David, Grilley-Olson, Juneko, Moschos, Stergios, Neil Hayes, D., Sharpless, Norman E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor clinical trials diagnostics Female genomics High-Throughput Nucleotide Sequencing Humans Male Melanoma - genetics Mutation Neoplasm Proteins - genetics resequencing therapeutics
Online-Zugang:	Volltext
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