Integrated Analysis Identifies Interaction Patterns between Small Molecules and Pathways
Previous studies have indicated that the downstream proteins in a key pathway can be potential drug targets and that the pathway can play an important role in the action of drugs. So pathways could be considered as targets of small molecules. A link map between small molecules and pathways was const...
Gespeichert in:
| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-10 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 10 |
|---|---|
| container_issue | 2014 |
| container_start_page | 1 |
| container_title | BioMed research international |
| container_volume | 2014 |
| creator | Li, Weiguo Li, Yan Chen, Xin Jiang, Hong Sun, Jiatong Chen, Huan Lv, Sali |
| description | Previous studies have indicated that the downstream proteins in a key pathway can be potential drug targets and that the pathway can play an important role in the action of drugs. So pathways could be considered as targets of small molecules. A link map between small molecules and pathways was constructed using gene expression profile, pathways, and gene expression of cancer cell line intervened by small molecules and then we analysed the topological characteristics of the link map. Three link patterns were identified based on different drug discovery implications for breast, liver, and lung cancer. Furthermore, molecules that significantly targeted the same pathways tended to treat the same diseases. These results can provide a valuable reference for identifying drug candidates and targets in molecularly targeted therapy. |
| doi_str_mv | 10.1155/2014/931825 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4121214</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A427025039</galeid><sourcerecordid>A427025039</sourcerecordid><originalsourceid>FETCH-LOGICAL-c527t-bd30b3840ef0f22cb510695d0327c673e77d8d11ddbc4e1f41be333153668e993</originalsourceid><addsrcrecordid>eNqFkttrFDEUh4MottQ--awM-CLK2pxc5vIiLMXLQkVBBd9CJjmzm5LNtMmMy_73Zpw6qC9NCDnhfPlxboQ8BfoGQMoLRkFcNBxqJh-QU8ZBrEoQ8HCxOT8h5yld07xqKGlTPiYnTAKI_OuU_NiEAbdRD2iLddD-mFwqNhbD4DqH2czuqM3g-lB80UN-hFS0OBwQQ_F1r70vPvUezegzrIOdoN1BH9MT8qjTPuH53X1Gvr9_9-3y4-rq84fN5fpqZSSrhlVrOW15LSh2tGPMtBJo2UhLOatMWXGsKltbAGtbIxA6AS1yzkHysqyxafgZeTvr3oztHq3JkUft1U10ex2PqtdO_esJbqe2_U8lgOUtssDLO4HY346YBrV3yaD3OmA_JgUl1NNp2P2olBxowxhk9MV_6HU_xlzg3xSrRSVzaxZqqz0qF7o-h2gmUbUWrKJMUj6l-HqmTOxTitgt2QFV0xSoaQrUPAWZfv53QRb2T88z8GoGdi5YfXD3qD2bYcwIdnqBZc6TMv4Lb2zBHg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1552847513</pqid></control><display><type>article</type><title>Integrated Analysis Identifies Interaction Patterns between Small Molecules and Pathways</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Li, Weiguo ; Li, Yan ; Chen, Xin ; Jiang, Hong ; Sun, Jiatong ; Chen, Huan ; Lv, Sali</creator><contributor>Zheng, Siyuan</contributor><creatorcontrib>Li, Weiguo ; Li, Yan ; Chen, Xin ; Jiang, Hong ; Sun, Jiatong ; Chen, Huan ; Lv, Sali ; Zheng, Siyuan</creatorcontrib><description>Previous studies have indicated that the downstream proteins in a key pathway can be potential drug targets and that the pathway can play an important role in the action of drugs. So pathways could be considered as targets of small molecules. A link map between small molecules and pathways was constructed using gene expression profile, pathways, and gene expression of cancer cell line intervened by small molecules and then we analysed the topological characteristics of the link map. Three link patterns were identified based on different drug discovery implications for breast, liver, and lung cancer. Furthermore, molecules that significantly targeted the same pathways tended to treat the same diseases. These results can provide a valuable reference for identifying drug candidates and targets in molecularly targeted therapy.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/931825</identifier><identifier>PMID: 25114931</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Antimitotic agents ; Antineoplastic agents ; Cancer cells ; Cancer therapies ; Cluster Analysis ; Complications and side effects ; Computational Biology - methods ; Databases, Genetic ; Disease ; Dosage and administration ; Drug targeting ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic - genetics ; Genetic engineering ; Humans ; Liver cancer ; Lung cancer ; Medical research ; Neoplasms - genetics ; Neoplasms - metabolism ; Signal Transduction - genetics ; Transcriptome - genetics ; Transcriptome - physiology</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-10</ispartof><rights>Copyright © 2014 Yan Li et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Yan Li et al. Yan Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Yan Li et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-bd30b3840ef0f22cb510695d0327c673e77d8d11ddbc4e1f41be333153668e993</citedby><cites>FETCH-LOGICAL-c527t-bd30b3840ef0f22cb510695d0327c673e77d8d11ddbc4e1f41be333153668e993</cites><orcidid>0000-0002-5570-3809</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121214/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121214/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25114931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Zheng, Siyuan</contributor><creatorcontrib>Li, Weiguo</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Jiang, Hong</creatorcontrib><creatorcontrib>Sun, Jiatong</creatorcontrib><creatorcontrib>Chen, Huan</creatorcontrib><creatorcontrib>Lv, Sali</creatorcontrib><title>Integrated Analysis Identifies Interaction Patterns between Small Molecules and Pathways</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Previous studies have indicated that the downstream proteins in a key pathway can be potential drug targets and that the pathway can play an important role in the action of drugs. So pathways could be considered as targets of small molecules. A link map between small molecules and pathways was constructed using gene expression profile, pathways, and gene expression of cancer cell line intervened by small molecules and then we analysed the topological characteristics of the link map. Three link patterns were identified based on different drug discovery implications for breast, liver, and lung cancer. Furthermore, molecules that significantly targeted the same pathways tended to treat the same diseases. These results can provide a valuable reference for identifying drug candidates and targets in molecularly targeted therapy.</description><subject>Antimitotic agents</subject><subject>Antineoplastic agents</subject><subject>Cancer cells</subject><subject>Cancer therapies</subject><subject>Cluster Analysis</subject><subject>Complications and side effects</subject><subject>Computational Biology - methods</subject><subject>Databases, Genetic</subject><subject>Disease</subject><subject>Dosage and administration</subject><subject>Drug targeting</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Genetic engineering</subject><subject>Humans</subject><subject>Liver cancer</subject><subject>Lung cancer</subject><subject>Medical research</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>Signal Transduction - genetics</subject><subject>Transcriptome - genetics</subject><subject>Transcriptome - physiology</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkttrFDEUh4MottQ--awM-CLK2pxc5vIiLMXLQkVBBd9CJjmzm5LNtMmMy_73Zpw6qC9NCDnhfPlxboQ8BfoGQMoLRkFcNBxqJh-QU8ZBrEoQ8HCxOT8h5yld07xqKGlTPiYnTAKI_OuU_NiEAbdRD2iLddD-mFwqNhbD4DqH2czuqM3g-lB80UN-hFS0OBwQQ_F1r70vPvUezegzrIOdoN1BH9MT8qjTPuH53X1Gvr9_9-3y4-rq84fN5fpqZSSrhlVrOW15LSh2tGPMtBJo2UhLOatMWXGsKltbAGtbIxA6AS1yzkHysqyxafgZeTvr3oztHq3JkUft1U10ex2PqtdO_esJbqe2_U8lgOUtssDLO4HY346YBrV3yaD3OmA_JgUl1NNp2P2olBxowxhk9MV_6HU_xlzg3xSrRSVzaxZqqz0qF7o-h2gmUbUWrKJMUj6l-HqmTOxTitgt2QFV0xSoaQrUPAWZfv53QRb2T88z8GoGdi5YfXD3qD2bYcwIdnqBZc6TMv4Lb2zBHg</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Li, Weiguo</creator><creator>Li, Yan</creator><creator>Chen, Xin</creator><creator>Jiang, Hong</creator><creator>Sun, Jiatong</creator><creator>Chen, Huan</creator><creator>Lv, Sali</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5570-3809</orcidid></search><sort><creationdate>20140101</creationdate><title>Integrated Analysis Identifies Interaction Patterns between Small Molecules and Pathways</title><author>Li, Weiguo ; Li, Yan ; Chen, Xin ; Jiang, Hong ; Sun, Jiatong ; Chen, Huan ; Lv, Sali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-bd30b3840ef0f22cb510695d0327c673e77d8d11ddbc4e1f41be333153668e993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antimitotic agents</topic><topic>Antineoplastic agents</topic><topic>Cancer cells</topic><topic>Cancer therapies</topic><topic>Cluster Analysis</topic><topic>Complications and side effects</topic><topic>Computational Biology - methods</topic><topic>Databases, Genetic</topic><topic>Disease</topic><topic>Dosage and administration</topic><topic>Drug targeting</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic - genetics</topic><topic>Genetic engineering</topic><topic>Humans</topic><topic>Liver cancer</topic><topic>Lung cancer</topic><topic>Medical research</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Signal Transduction - genetics</topic><topic>Transcriptome - genetics</topic><topic>Transcriptome - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Weiguo</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Jiang, Hong</creatorcontrib><creatorcontrib>Sun, Jiatong</creatorcontrib><creatorcontrib>Chen, Huan</creatorcontrib><creatorcontrib>Lv, Sali</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>Proquest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Weiguo</au><au>Li, Yan</au><au>Chen, Xin</au><au>Jiang, Hong</au><au>Sun, Jiatong</au><au>Chen, Huan</au><au>Lv, Sali</au><au>Zheng, Siyuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Integrated Analysis Identifies Interaction Patterns between Small Molecules and Pathways</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Previous studies have indicated that the downstream proteins in a key pathway can be potential drug targets and that the pathway can play an important role in the action of drugs. So pathways could be considered as targets of small molecules. A link map between small molecules and pathways was constructed using gene expression profile, pathways, and gene expression of cancer cell line intervened by small molecules and then we analysed the topological characteristics of the link map. Three link patterns were identified based on different drug discovery implications for breast, liver, and lung cancer. Furthermore, molecules that significantly targeted the same pathways tended to treat the same diseases. These results can provide a valuable reference for identifying drug candidates and targets in molecularly targeted therapy.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>25114931</pmid><doi>10.1155/2014/931825</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-5570-3809</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2314-6133 |
| ispartof | BioMed research international, 2014-01, Vol.2014 (2014), p.1-10 |
| issn | 2314-6133 2314-6141 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4121214 |
| source | MEDLINE; PubMed Central Open Access; Wiley Online Library (Open Access Collection); PubMed Central; Alma/SFX Local Collection |
| subjects | Antimitotic agents Antineoplastic agents Cancer cells Cancer therapies Cluster Analysis Complications and side effects Computational Biology - methods Databases, Genetic Disease Dosage and administration Drug targeting Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic - genetics Genetic engineering Humans Liver cancer Lung cancer Medical research Neoplasms - genetics Neoplasms - metabolism Signal Transduction - genetics Transcriptome - genetics Transcriptome - physiology |
| title | Integrated Analysis Identifies Interaction Patterns between Small Molecules and Pathways |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T02%3A50%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Integrated%20Analysis%20Identifies%20Interaction%20Patterns%20between%20Small%20Molecules%20and%20Pathways&rft.jtitle=BioMed%20research%20international&rft.au=Li,%20Weiguo&rft.date=2014-01-01&rft.volume=2014&rft.issue=2014&rft.spage=1&rft.epage=10&rft.pages=1-10&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2014/931825&rft_dat=%3Cgale_pubme%3EA427025039%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1552847513&rft_id=info:pmid/25114931&rft_galeid=A427025039&rfr_iscdi=true |