Exopolysaccharide from Ganoderma applanatum as a Promising Bioactive Compound with Cytostatic and Antibacterial Properties
A new exopolysaccharide preparation isolated from stationary cultures of the white rot fungus Ganoderma applanatum (GpEPS) was tested in terms of its bioactive properties including its cytotoxic and immunostimulatory effect. The results indicate that the tested GpEPS (at concentrations above 22.85 µ...
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| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-10 |
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| creator | Osińska-Jaroszuk, Monika Jaszek, Magdalena Mizerska-Dudka, Magdalena Błachowicz, Adriana Rejczak, Tomasz Piotr Janusz, Grzegorz Wydrych, Jerzy Polak, Jolanta Jarosz-Wilkołazka, Anna Kandefer-Szerszeń, Martyna |
| description | A new exopolysaccharide preparation isolated from stationary cultures of the white rot fungus Ganoderma applanatum (GpEPS) was tested in terms of its bioactive properties including its cytotoxic and immunostimulatory effect. The results indicate that the tested GpEPS (at concentrations above 22.85 µg/mL and 228.5 µg/mL) may exhibit selective activity against tumor cells (cell lines SiHa) and stimulate production of TNF-α THP-1-derived macrophages at the level of 752.17 pg/mL. The GpEPS showed antibacterial properties against Staphyloccoccus aureus and a toxic effect against Vibrio fischeri cells (82.8% cell damage). High cholesterol-binding capacity and triglycerides-binding capacity (57.9% and 41.6% after 24 h of incubation with the tested substances, resp.) were also detected for the investigated samples of GpEPS. |
| doi_str_mv | 10.1155/2014/743812 |
| format | Article |
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The results indicate that the tested GpEPS (at concentrations above 22.85 µg/mL and 228.5 µg/mL) may exhibit selective activity against tumor cells (cell lines SiHa) and stimulate production of TNF-α THP-1-derived macrophages at the level of 752.17 pg/mL. The GpEPS showed antibacterial properties against Staphyloccoccus aureus and a toxic effect against Vibrio fischeri cells (82.8% cell damage). High cholesterol-binding capacity and triglycerides-binding capacity (57.9% and 41.6% after 24 h of incubation with the tested substances, resp.) were also detected for the investigated samples of GpEPS.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/743812</identifier><identifier>PMID: 25114920</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Aliivibrio fischeri - drug effects ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Biomedical research ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cytostatic Agents - chemistry ; Cytostatic Agents - pharmacology ; Deoxyribonucleic acid ; DNA ; Experiments ; Free radicals ; Fungal Polysaccharides - chemistry ; Fungal Polysaccharides - pharmacology ; Ganoderma - chemistry ; Ganoderma applanatum ; Genetic testing ; Glucose ; Humans ; Immunologic Factors ; Macrophages ; Microbial Viability - drug effects ; Molecular weight ; Polysaccharides ; Reishi ; Triglycerides ; Tumor necrosis factor ; Vibrio fischeri</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-10</ispartof><rights>Copyright © 2014 Monika Osińska-Jaroszuk et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Monika Osinska-Jaroszuk et al. Monika Osinska-Jaroszuk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Monika Osińska-Jaroszuk et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-23723147d893e204da70648bc500533cd6088b35b3dc2e2fa114290216d7babe3</citedby><cites>FETCH-LOGICAL-c490t-23723147d893e204da70648bc500533cd6088b35b3dc2e2fa114290216d7babe3</cites><orcidid>0000-0003-1822-2181 ; 0000-0003-2364-6181 ; 0000-0003-2609-1820 ; 0000-0002-2046-2806</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120920/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120920/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25114920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Odeku, Oluwatoyin A.</contributor><creatorcontrib>Osińska-Jaroszuk, Monika</creatorcontrib><creatorcontrib>Jaszek, Magdalena</creatorcontrib><creatorcontrib>Mizerska-Dudka, Magdalena</creatorcontrib><creatorcontrib>Błachowicz, Adriana</creatorcontrib><creatorcontrib>Rejczak, Tomasz Piotr</creatorcontrib><creatorcontrib>Janusz, Grzegorz</creatorcontrib><creatorcontrib>Wydrych, Jerzy</creatorcontrib><creatorcontrib>Polak, Jolanta</creatorcontrib><creatorcontrib>Jarosz-Wilkołazka, Anna</creatorcontrib><creatorcontrib>Kandefer-Szerszeń, Martyna</creatorcontrib><title>Exopolysaccharide from Ganoderma applanatum as a Promising Bioactive Compound with Cytostatic and Antibacterial Properties</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>A new exopolysaccharide preparation isolated from stationary cultures of the white rot fungus Ganoderma applanatum (GpEPS) was tested in terms of its bioactive properties including its cytotoxic and immunostimulatory effect. The results indicate that the tested GpEPS (at concentrations above 22.85 µg/mL and 228.5 µg/mL) may exhibit selective activity against tumor cells (cell lines SiHa) and stimulate production of TNF-α THP-1-derived macrophages at the level of 752.17 pg/mL. The GpEPS showed antibacterial properties against Staphyloccoccus aureus and a toxic effect against Vibrio fischeri cells (82.8% cell damage). High cholesterol-binding capacity and triglycerides-binding capacity (57.9% and 41.6% after 24 h of incubation with the tested substances, resp.) were also detected for the investigated samples of GpEPS.</description><subject>Aliivibrio fischeri - drug effects</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biomedical research</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cytostatic Agents - chemistry</subject><subject>Cytostatic Agents - pharmacology</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Experiments</subject><subject>Free radicals</subject><subject>Fungal Polysaccharides - chemistry</subject><subject>Fungal Polysaccharides - pharmacology</subject><subject>Ganoderma - chemistry</subject><subject>Ganoderma applanatum</subject><subject>Genetic testing</subject><subject>Glucose</subject><subject>Humans</subject><subject>Immunologic Factors</subject><subject>Macrophages</subject><subject>Microbial Viability - 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The results indicate that the tested GpEPS (at concentrations above 22.85 µg/mL and 228.5 µg/mL) may exhibit selective activity against tumor cells (cell lines SiHa) and stimulate production of TNF-α THP-1-derived macrophages at the level of 752.17 pg/mL. The GpEPS showed antibacterial properties against Staphyloccoccus aureus and a toxic effect against Vibrio fischeri cells (82.8% cell damage). High cholesterol-binding capacity and triglycerides-binding capacity (57.9% and 41.6% after 24 h of incubation with the tested substances, resp.) were also detected for the investigated samples of GpEPS.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>25114920</pmid><doi>10.1155/2014/743812</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-1822-2181</orcidid><orcidid>https://orcid.org/0000-0003-2364-6181</orcidid><orcidid>https://orcid.org/0000-0003-2609-1820</orcidid><orcidid>https://orcid.org/0000-0002-2046-2806</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aliivibrio fischeri - drug effects Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biomedical research Cell Line, Tumor Cell Proliferation - drug effects Cytostatic Agents - chemistry Cytostatic Agents - pharmacology Deoxyribonucleic acid DNA Experiments Free radicals Fungal Polysaccharides - chemistry Fungal Polysaccharides - pharmacology Ganoderma - chemistry Ganoderma applanatum Genetic testing Glucose Humans Immunologic Factors Macrophages Microbial Viability - drug effects Molecular weight Polysaccharides Reishi Triglycerides Tumor necrosis factor Vibrio fischeri |
| title | Exopolysaccharide from Ganoderma applanatum as a Promising Bioactive Compound with Cytostatic and Antibacterial Properties |
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