Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells

Abstract Exosomes, nano-vesicles naturally released from living cells, have been well recognized to play critical roles in mediating cell-to-cell communication. Given that diabetic hearts exhibit insufficient angiogenesis, it is significant to test whether diabetic cardiomyocyte-derived exosomes pos...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2014-09, Vol.74, p.139-150
Hauptverfasser:	Wang, Xiaohong, Huang, Wei, Liu, Guansheng, Cai, Wenfeng, Millard, Ronald W, Wang, Yigang, Chang, Jiang, Peng, Tianqing, Fan, Guo-Chang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - pharmacology Animals Benzylidene Compounds - pharmacology Biological Transport Biomarkers - metabolism Cardiomyocytes Cardiovascular Cell Movement Cell Proliferation Coculture Techniques Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelial Cells - pathology Exosomes Exosomes - drug effects Exosomes - metabolism Exosomes - pathology Gene Expression Regulation HSP20 Heat-Shock Proteins - genetics HSP20 Heat-Shock Proteins - metabolism Humans Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism MicroRNAs - genetics MicroRNAs - metabolism miR-320 Myocardial angiogenesis Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Neovascularization, Physiologic Proto-Oncogene Protein c-ets-2 - genetics Proto-Oncogene Protein c-ets-2 - metabolism Rats Rats, Wistar Signal Transduction Type 2 diabetes
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