Nucleosome repositioning links DNA (de)methylation and differential CTCF binding during stem cell development

During differentiation of embryonic stem cells, chromatin reorganizes to establish cell type-specific expression programs. Here, we have dissected the linkages between DNA methylation (5mC), hydroxymethylation (5hmC), nucleosome repositioning, and binding of the transcription factor CTCF during this...

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Veröffentlicht in:	Genome research 2014-08, Vol.24 (8), p.1285-1295
Hauptverfasser:	Teif, Vladimir B, Beshnova, Daria A, Vainshtein, Yevhen, Marth, Caroline, Mallm, Jan-Philipp, Höfer, Thomas, Rippe, Karsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CCCTC-Binding Factor Cell Differentiation Cells, Cultured Chromatin Assembly and Disassembly CpG Islands DNA Methylation DNA-Binding Proteins - metabolism Embryonic Stem Cells - physiology Mice, 129 Strain Nucleosomes - metabolism Protein Binding Proto-Oncogene Proteins - metabolism Repressor Proteins - metabolism
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