Butylidenephthalide Blocks Potassium Channels and Enhances Basal Tension in Isolated Guinea-Pig Trachea

Butylidenephthalide (Bdph, 30~300 μM), a constituent of Ligusticum chuanxiong Hort., significantly enhanced tension in isolated guinea-pig trachea. In this study, we investigate the mechanism(s) of Bdph-induced contraction in the tissue. Isolated trachea was bathed in 5 mL of Krebs solution containi...

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Veröffentlicht in:	BioMed research international 2014-01, Vol.2014 (2014), p.1-7
Hauptverfasser:	Hsu, Hsin-Te, Yang, You-Lan, Chen, Wan-Chen, Chen, Chi-Ming, Ko, Wun-Chang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia Biomedical research Calcium Channel Blockers - pharmacology Chinese medicine Colleges & universities Drug Antagonism Experiments Guinea Pigs Health aspects Ligusticum Male Materia medica, Vegetable Medical research Medicinal plants Muscle Relaxation - drug effects Nifedipine - pharmacology Phthalic Anhydrides - pharmacology Plant extracts Potassium channels Potassium Channels - drug effects Rodents Smooth muscle Stroke Trachea Trachea - drug effects Trachea - physiology Verapamil - pharmacology
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