Butylidenephthalide Blocks Potassium Channels and Enhances Basal Tension in Isolated Guinea-Pig Trachea
Butylidenephthalide (Bdph, 30~300 μM), a constituent of Ligusticum chuanxiong Hort., significantly enhanced tension in isolated guinea-pig trachea. In this study, we investigate the mechanism(s) of Bdph-induced contraction in the tissue. Isolated trachea was bathed in 5 mL of Krebs solution containi...
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| description | Butylidenephthalide (Bdph, 30~300 μM), a constituent of Ligusticum chuanxiong Hort., significantly enhanced tension in isolated guinea-pig trachea. In this study, we investigate the mechanism(s) of Bdph-induced contraction in the tissue. Isolated trachea was bathed in 5 mL of Krebs solution containing indomethacin (3 μM), and its tension changes were isometrically recorded. Cromakalim (3 μM), an ATP-dependent K+ channel opener, significantly antagonized the Bdph-induced enhancement of baseline tension. Bdph (300 μM) also significantly antagonized cromakalim-induced relaxation. Bdph (300 μM) did not significantly influence the antagonistic effects of glibenclamide (GBC, 1 μM) and tetraethylammonium (TEA, 8 mM) against the cromakalim-induced relaxation. However, Bdph (300 μM) and 4-aminopiridine (4-AP, 5 mM), a blocker of Kv1 family of K+ channels, in combination significantly rightward shifted the log concentration-relaxation curve of cromakalim. The antagonistic effect of the combination almost equals the sum of the individual effects of Bdph and 4-AP, suggesting that the antagonistic mechanism of Bdph may be similar to that of 4-AP. All calcium channel blockers influenced neither the baseline tension nor antagonistic effect of Bdph against cromakalim. In conclusion, Bdph may be similar to 4-AP, a blocker of Kv1 family of K+ channels, to enhance the baseline tension of guinea-pig trachea. |
| doi_str_mv | 10.1155/2014/875230 |
| format | Article |
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In this study, we investigate the mechanism(s) of Bdph-induced contraction in the tissue. Isolated trachea was bathed in 5 mL of Krebs solution containing indomethacin (3 μM), and its tension changes were isometrically recorded. Cromakalim (3 μM), an ATP-dependent K+ channel opener, significantly antagonized the Bdph-induced enhancement of baseline tension. Bdph (300 μM) also significantly antagonized cromakalim-induced relaxation. Bdph (300 μM) did not significantly influence the antagonistic effects of glibenclamide (GBC, 1 μM) and tetraethylammonium (TEA, 8 mM) against the cromakalim-induced relaxation. However, Bdph (300 μM) and 4-aminopiridine (4-AP, 5 mM), a blocker of Kv1 family of K+ channels, in combination significantly rightward shifted the log concentration-relaxation curve of cromakalim. The antagonistic effect of the combination almost equals the sum of the individual effects of Bdph and 4-AP, suggesting that the antagonistic mechanism of Bdph may be similar to that of 4-AP. All calcium channel blockers influenced neither the baseline tension nor antagonistic effect of Bdph against cromakalim. In conclusion, Bdph may be similar to 4-AP, a blocker of Kv1 family of K+ channels, to enhance the baseline tension of guinea-pig trachea.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/875230</identifier><identifier>PMID: 25114927</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Animals ; Ataxia ; Biomedical research ; Calcium Channel Blockers - pharmacology ; Chinese medicine ; Colleges & universities ; Drug Antagonism ; Experiments ; Guinea Pigs ; Health aspects ; Ligusticum ; Male ; Materia medica, Vegetable ; Medical research ; Medicinal plants ; Muscle Relaxation - drug effects ; Nifedipine - pharmacology ; Phthalic Anhydrides - pharmacology ; Plant extracts ; Potassium channels ; Potassium Channels - drug effects ; Rodents ; Smooth muscle ; Stroke ; Trachea ; Trachea - drug effects ; Trachea - physiology ; Verapamil - pharmacology</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-7</ispartof><rights>Copyright © 2014 Hsin-Te Hsu et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Hsin-Te Hsu et al. Hsin-Te Hsu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Hsin-Te Hsu et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-acabc5e1c94bc4d95c490d7bca4d56c55a383b8ee8a9d56df84c7d18d5a03cfd3</citedby><cites>FETCH-LOGICAL-c527t-acabc5e1c94bc4d95c490d7bca4d56c55a383b8ee8a9d56df84c7d18d5a03cfd3</cites><orcidid>0000-0002-1823-9824</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119919/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119919/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27915,27916,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25114927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Tomoda, Akio</contributor><creatorcontrib>Hsu, Hsin-Te</creatorcontrib><creatorcontrib>Yang, You-Lan</creatorcontrib><creatorcontrib>Chen, Wan-Chen</creatorcontrib><creatorcontrib>Chen, Chi-Ming</creatorcontrib><creatorcontrib>Ko, Wun-Chang</creatorcontrib><title>Butylidenephthalide Blocks Potassium Channels and Enhances Basal Tension in Isolated Guinea-Pig Trachea</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Butylidenephthalide (Bdph, 30~300 μM), a constituent of Ligusticum chuanxiong Hort., significantly enhanced tension in isolated guinea-pig trachea. In this study, we investigate the mechanism(s) of Bdph-induced contraction in the tissue. Isolated trachea was bathed in 5 mL of Krebs solution containing indomethacin (3 μM), and its tension changes were isometrically recorded. Cromakalim (3 μM), an ATP-dependent K+ channel opener, significantly antagonized the Bdph-induced enhancement of baseline tension. Bdph (300 μM) also significantly antagonized cromakalim-induced relaxation. Bdph (300 μM) did not significantly influence the antagonistic effects of glibenclamide (GBC, 1 μM) and tetraethylammonium (TEA, 8 mM) against the cromakalim-induced relaxation. However, Bdph (300 μM) and 4-aminopiridine (4-AP, 5 mM), a blocker of Kv1 family of K+ channels, in combination significantly rightward shifted the log concentration-relaxation curve of cromakalim. The antagonistic effect of the combination almost equals the sum of the individual effects of Bdph and 4-AP, suggesting that the antagonistic mechanism of Bdph may be similar to that of 4-AP. All calcium channel blockers influenced neither the baseline tension nor antagonistic effect of Bdph against cromakalim. In conclusion, Bdph may be similar to 4-AP, a blocker of Kv1 family of K+ channels, to enhance the baseline tension of guinea-pig trachea.</description><subject>Animals</subject><subject>Ataxia</subject><subject>Biomedical research</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Chinese medicine</subject><subject>Colleges & universities</subject><subject>Drug Antagonism</subject><subject>Experiments</subject><subject>Guinea Pigs</subject><subject>Health aspects</subject><subject>Ligusticum</subject><subject>Male</subject><subject>Materia medica, Vegetable</subject><subject>Medical research</subject><subject>Medicinal plants</subject><subject>Muscle Relaxation - drug effects</subject><subject>Nifedipine - pharmacology</subject><subject>Phthalic Anhydrides - pharmacology</subject><subject>Plant extracts</subject><subject>Potassium channels</subject><subject>Potassium Channels - drug effects</subject><subject>Rodents</subject><subject>Smooth muscle</subject><subject>Stroke</subject><subject>Trachea</subject><subject>Trachea - 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In this study, we investigate the mechanism(s) of Bdph-induced contraction in the tissue. Isolated trachea was bathed in 5 mL of Krebs solution containing indomethacin (3 μM), and its tension changes were isometrically recorded. Cromakalim (3 μM), an ATP-dependent K+ channel opener, significantly antagonized the Bdph-induced enhancement of baseline tension. Bdph (300 μM) also significantly antagonized cromakalim-induced relaxation. Bdph (300 μM) did not significantly influence the antagonistic effects of glibenclamide (GBC, 1 μM) and tetraethylammonium (TEA, 8 mM) against the cromakalim-induced relaxation. However, Bdph (300 μM) and 4-aminopiridine (4-AP, 5 mM), a blocker of Kv1 family of K+ channels, in combination significantly rightward shifted the log concentration-relaxation curve of cromakalim. The antagonistic effect of the combination almost equals the sum of the individual effects of Bdph and 4-AP, suggesting that the antagonistic mechanism of Bdph may be similar to that of 4-AP. All calcium channel blockers influenced neither the baseline tension nor antagonistic effect of Bdph against cromakalim. In conclusion, Bdph may be similar to 4-AP, a blocker of Kv1 family of K+ channels, to enhance the baseline tension of guinea-pig trachea.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>25114927</pmid><doi>10.1155/2014/875230</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1823-9824</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Ataxia Biomedical research Calcium Channel Blockers - pharmacology Chinese medicine Colleges & universities Drug Antagonism Experiments Guinea Pigs Health aspects Ligusticum Male Materia medica, Vegetable Medical research Medicinal plants Muscle Relaxation - drug effects Nifedipine - pharmacology Phthalic Anhydrides - pharmacology Plant extracts Potassium channels Potassium Channels - drug effects Rodents Smooth muscle Stroke Trachea Trachea - drug effects Trachea - physiology Verapamil - pharmacology |
| title | Butylidenephthalide Blocks Potassium Channels and Enhances Basal Tension in Isolated Guinea-Pig Trachea |
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