Epigenetic Silencing of CXCR4 Promotes Loss of Cell Adhesion in Cervical Cancer

In the network of chemokine signaling pathways, recent reports have described the SDF-1α/CXCR4 axis and its role in cancer progression and metastasis. Interestingly, we found downregulation of CXCR4 at both transcript and protein level in cervical cancer cell lines and primary tumors. We also found...

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Veröffentlicht in:	BioMed research international 2014-01, Vol.2014 (2014), p.1-13
Hauptverfasser:	Yadav, Suresh Singh, Prasad, Shyam Babu, Das, Mitali, Kumari, Soni, Pandey, Lakshmi Kant, Singh, Sunita, Pradhan, Satyajit, Narayan, Gopeshwar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Breast cancer Cell adhesion Cell adhesion & migration Cell Adhesion - genetics Cell Line, Tumor Cervical cancer Cervix Uteri - chemistry Cervix Uteri - pathology Chemokine CXCL12 - genetics Chemokine CXCL12 - metabolism DNA Methylation Epigenetic inheritance Female Gene Silencing - physiology Humans Metastasis Middle Aged Receptors, CXCR4 - genetics Receptors, CXCR4 - metabolism Tumor Microenvironment Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology
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