A Genome-Wide Association Study to Identify Genomic Modulators of Rate Control Therapy in Patients With Atrial Fibrillation

For many patients with atrial fibrillation, ventricular rate control with atrioventricular (AV) nodal blockers is considered first-line therapy, although response to treatment is highly variable. Using an extreme phenotype of failure of rate control necessitating AV nodal ablation and pacemaker impl...

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Veröffentlicht in:	The American journal of cardiology 2014-08, Vol.114 (4), p.593-600
Hauptverfasser:	Kolek, Matthew J., MD, Edwards, Todd L., PhD, Muhammad, Raafia, MD, Balouch, Adnan, MD, Shoemaker, M. Benjamin, MD, Blair, Marcia A., MS, Kor, Kaylen C., BE, Takahashi, Atsushi, PhD, Kubo, Michiaki, MD, PhD, Roden, Dan M., MD, Tanaka, Toshihiro, MD, PhD, Darbar, Dawood, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anti-Arrhythmia Agents - therapeutic use Atrial Fibrillation - drug therapy Atrial Fibrillation - genetics Atrial Fibrillation - physiopathology Atrioventricular Node - drug effects Atrioventricular Node - physiopathology Cardiac arrhythmia Cardiovascular Chromosomes Confidence intervals Deoxyribonucleic acid DNA DNA - genetics Electrocardiography Female Follow-Up Studies Gender Genome-Wide Association Study - methods Genomes Genomics Genotype Genotype & phenotype Heart Rate - physiology Humans Male Middle Aged Phenotype Polymorphism, Single Nucleotide Quality control Retrospective Studies SOXD Transcription Factors - genetics SOXD Transcription Factors - metabolism Time Factors
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