Interleukin 33: a switch-hitting cytokine

Interleukin 33: a switch-hitting cytokine

Highlights • IL-33 is a proinflammtory cytokine with pleiotropic properties. • IL-33 activities far exceed the Th2 immunity also promoting Th1 and CD8 responses. • IL-33 can drive antiviral and antitumor immunity. • IL-33 can act as a new potent immunoadjuvant.

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Bibliographische Detailangaben
Veröffentlicht in:Current opinion in immunology 2014-06, Vol.28, p.102-106
Hauptverfasser: Villarreal, Daniel O, Weiner, David B
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Cytokines - immunology
Humans
Interleukins - immunology
Neoplasms - immunology
Th1 Cells - immunology
Th2 Cells - immunology
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Zusammenfassung:Highlights • IL-33 is a proinflammtory cytokine with pleiotropic properties. • IL-33 activities far exceed the Th2 immunity also promoting Th1 and CD8 responses. • IL-33 can drive antiviral and antitumor immunity. • IL-33 can act as a new potent immunoadjuvant.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2014.03.004