The Changing Demographics of Knee Dislocation: A Retrospective Database Review

Background Knee dislocations are uncommon but devastating orthopaedic injuries. Little is known about their frequency and the types of patients who are affected. Questions/purposes Using a large national insurance database, we determined (1) the incidence of knee dislocation in patients with orthopa...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinical orthopaedics and related research 2014-09, Vol.472 (9), p.2609-2614
Hauptverfasser: Arom, Gabriel A., Yeranosian, Michael G., Petrigliano, Frank A., Terrell, Rodney D., McAllister, David R.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 2614
container_issue 9
container_start_page 2609
container_title Clinical orthopaedics and related research
container_volume 472
creator Arom, Gabriel A.
Yeranosian, Michael G.
Petrigliano, Frank A.
Terrell, Rodney D.
McAllister, David R.
description Background Knee dislocations are uncommon but devastating orthopaedic injuries. Little is known about their frequency and the types of patients who are affected. Questions/purposes Using a large national insurance database, we determined (1) the incidence of knee dislocation in patients with orthopaedic injuries and examined the incidence as a function of (2) year of diagnosis, (3) dislocation type (open versus closed, direction), and (4) patient demographic factors (sex, age). Methods We searched the PearlDiver database, a national database of private insurance records consisting of 11 million patients with orthopaedic diagnoses, using diagnosis (ICD-9-CM) codes for knee dislocation between the years 2004 and 2009. The PearlDiver database does not include Medicare, Medicaid, or uninsured patients. Patients were stratified by age, sex, and year of diagnosis. Incidence was defined as the number of dislocation events per 100 patient-years. Results We identified 8050 dislocations, representing an incidence of 0.072 events per 100 patient-years between 2004 and 2009. Annual dislocation incidence did not increase during the 6-year study period. Of the 8050 dislocations, 1333 (17%) were open and 6717 (83%) were closed, representing an incidence of 0.060 per 100 for closed dislocations and 0.012 per 100 for open dislocations. The most common direction of dislocation was unspecified or other (65%), followed by anterior (13%), lateral (11%), posterior (6%), and medial (5%). Of the patients sustaining dislocations, 4172 (52%) were female and 3878 (48%) were male. Males displayed an increased risk of knee dislocation compared to females (odds ratio = 1.09). The mean patient age was 35 years, and patient age was inversely correlated to the incidence of knee dislocation (10-year odds ratio = 0.77). Conclusions Our data suggest that knee dislocation might represent a significantly larger burden among orthopaedic injuries than previously thought. The finding that males and females have a nearly equal risk of knee dislocation enhances the diagnosing physician’s clinical suspicion of this injury. Future large prospective studies analyzing the various causes of knee dislocation could provide insight into the changing demographics of this injury. Level of Evidence Level IV, prognostic study. See Instructions for Authors for a complete description of levels of evidence.
doi_str_mv 10.1007/s11999-013-3373-0
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4117912</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1551024522</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-d7fb4d3ab69229b43d103e3097874d47225270bf4d1c4182df664b0eda0fb2da3</originalsourceid><addsrcrecordid>eNp1kdFrFDEQxoNY7LX6B_giC774snVmkr29-CCUq61iUZAKvoXs7uxeyl5yJnsn_vfNcbVUwaeQfL_5JjOfEC8RzhCgfpsQtdYloCylrGUJT8QMK1qUiJKeihkA6FIT_jgWJynd5qtUFT0Tx6QI1YJoJr7crLhYrqwfnB-KC16HIdrNyrWpCH3x2TMXFy6NobWTC_5dcV584ymGtOF2crss2sk2NnF-3jn-9Vwc9XZM_OL-PBXfLz_cLD-W11-vPi3Pr8u2AjmVXd03qpO2mWsi3SjZIUiWoOtFrTpVE1VUQ9OrDluFC-r6-Vw1wJ2FvqHOylPx_uC72TZr7lr2U7Sj2US3tvG3CdaZvxXvVmYIO6MQa42UDd7cG8Twc8tpMmuXWh5H6zlsk8GqQqC8rT36-h_0Nmyjz-PtqZwDSF1lCg9Um7eTIvcPn0Ew-7TMIS2T0zL7tAzkmlePp3io-BNPBugApCz5geOj1v91vQO1RJ85</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1550070395</pqid></control><display><type>article</type><title>The Changing Demographics of Knee Dislocation: A Retrospective Database Review</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Arom, Gabriel A. ; Yeranosian, Michael G. ; Petrigliano, Frank A. ; Terrell, Rodney D. ; McAllister, David R.</creator><creatorcontrib>Arom, Gabriel A. ; Yeranosian, Michael G. ; Petrigliano, Frank A. ; Terrell, Rodney D. ; McAllister, David R.</creatorcontrib><description>Background Knee dislocations are uncommon but devastating orthopaedic injuries. Little is known about their frequency and the types of patients who are affected. Questions/purposes Using a large national insurance database, we determined (1) the incidence of knee dislocation in patients with orthopaedic injuries and examined the incidence as a function of (2) year of diagnosis, (3) dislocation type (open versus closed, direction), and (4) patient demographic factors (sex, age). Methods We searched the PearlDiver database, a national database of private insurance records consisting of 11 million patients with orthopaedic diagnoses, using diagnosis (ICD-9-CM) codes for knee dislocation between the years 2004 and 2009. The PearlDiver database does not include Medicare, Medicaid, or uninsured patients. Patients were stratified by age, sex, and year of diagnosis. Incidence was defined as the number of dislocation events per 100 patient-years. Results We identified 8050 dislocations, representing an incidence of 0.072 events per 100 patient-years between 2004 and 2009. Annual dislocation incidence did not increase during the 6-year study period. Of the 8050 dislocations, 1333 (17%) were open and 6717 (83%) were closed, representing an incidence of 0.060 per 100 for closed dislocations and 0.012 per 100 for open dislocations. The most common direction of dislocation was unspecified or other (65%), followed by anterior (13%), lateral (11%), posterior (6%), and medial (5%). Of the patients sustaining dislocations, 4172 (52%) were female and 3878 (48%) were male. Males displayed an increased risk of knee dislocation compared to females (odds ratio = 1.09). The mean patient age was 35 years, and patient age was inversely correlated to the incidence of knee dislocation (10-year odds ratio = 0.77). Conclusions Our data suggest that knee dislocation might represent a significantly larger burden among orthopaedic injuries than previously thought. The finding that males and females have a nearly equal risk of knee dislocation enhances the diagnosing physician’s clinical suspicion of this injury. Future large prospective studies analyzing the various causes of knee dislocation could provide insight into the changing demographics of this injury. Level of Evidence Level IV, prognostic study. See Instructions for Authors for a complete description of levels of evidence.</description><identifier>ISSN: 0009-921X</identifier><identifier>EISSN: 1528-1132</identifier><identifier>DOI: 10.1007/s11999-013-3373-0</identifier><identifier>PMID: 24214822</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adolescent ; Adult ; Age Distribution ; Aged ; Child ; Conservative Orthopedics ; Databases, Factual ; Demography - trends ; Female ; Humans ; Incidence ; Knee ; Knee Dislocation - epidemiology ; Male ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Orthopedics ; Orthopedics - statistics &amp; numerical data ; Retrospective Studies ; Sex Distribution ; Sports Medicine ; Surgery ; Surgical Orthopedics ; Symposium: Management of the Dislocated Knee ; United States - epidemiology ; Young Adult</subject><ispartof>Clinical orthopaedics and related research, 2014-09, Vol.472 (9), p.2609-2614</ispartof><rights>The Association of Bone and Joint Surgeons® 2013</rights><rights>The Association of Bone and Joint Surgeons 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-d7fb4d3ab69229b43d103e3097874d47225270bf4d1c4182df664b0eda0fb2da3</citedby><cites>FETCH-LOGICAL-c503t-d7fb4d3ab69229b43d103e3097874d47225270bf4d1c4182df664b0eda0fb2da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117912/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117912/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24214822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arom, Gabriel A.</creatorcontrib><creatorcontrib>Yeranosian, Michael G.</creatorcontrib><creatorcontrib>Petrigliano, Frank A.</creatorcontrib><creatorcontrib>Terrell, Rodney D.</creatorcontrib><creatorcontrib>McAllister, David R.</creatorcontrib><title>The Changing Demographics of Knee Dislocation: A Retrospective Database Review</title><title>Clinical orthopaedics and related research</title><addtitle>Clin Orthop Relat Res</addtitle><addtitle>Clin Orthop Relat Res</addtitle><description>Background Knee dislocations are uncommon but devastating orthopaedic injuries. Little is known about their frequency and the types of patients who are affected. Questions/purposes Using a large national insurance database, we determined (1) the incidence of knee dislocation in patients with orthopaedic injuries and examined the incidence as a function of (2) year of diagnosis, (3) dislocation type (open versus closed, direction), and (4) patient demographic factors (sex, age). Methods We searched the PearlDiver database, a national database of private insurance records consisting of 11 million patients with orthopaedic diagnoses, using diagnosis (ICD-9-CM) codes for knee dislocation between the years 2004 and 2009. The PearlDiver database does not include Medicare, Medicaid, or uninsured patients. Patients were stratified by age, sex, and year of diagnosis. Incidence was defined as the number of dislocation events per 100 patient-years. Results We identified 8050 dislocations, representing an incidence of 0.072 events per 100 patient-years between 2004 and 2009. Annual dislocation incidence did not increase during the 6-year study period. Of the 8050 dislocations, 1333 (17%) were open and 6717 (83%) were closed, representing an incidence of 0.060 per 100 for closed dislocations and 0.012 per 100 for open dislocations. The most common direction of dislocation was unspecified or other (65%), followed by anterior (13%), lateral (11%), posterior (6%), and medial (5%). Of the patients sustaining dislocations, 4172 (52%) were female and 3878 (48%) were male. Males displayed an increased risk of knee dislocation compared to females (odds ratio = 1.09). The mean patient age was 35 years, and patient age was inversely correlated to the incidence of knee dislocation (10-year odds ratio = 0.77). Conclusions Our data suggest that knee dislocation might represent a significantly larger burden among orthopaedic injuries than previously thought. The finding that males and females have a nearly equal risk of knee dislocation enhances the diagnosing physician’s clinical suspicion of this injury. Future large prospective studies analyzing the various causes of knee dislocation could provide insight into the changing demographics of this injury. Level of Evidence Level IV, prognostic study. See Instructions for Authors for a complete description of levels of evidence.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Child</subject><subject>Conservative Orthopedics</subject><subject>Databases, Factual</subject><subject>Demography - trends</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Knee</subject><subject>Knee Dislocation - epidemiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>Orthopedics</subject><subject>Orthopedics - statistics &amp; numerical data</subject><subject>Retrospective Studies</subject><subject>Sex Distribution</subject><subject>Sports Medicine</subject><subject>Surgery</subject><subject>Surgical Orthopedics</subject><subject>Symposium: Management of the Dislocated Knee</subject><subject>United States - epidemiology</subject><subject>Young Adult</subject><issn>0009-921X</issn><issn>1528-1132</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kdFrFDEQxoNY7LX6B_giC774snVmkr29-CCUq61iUZAKvoXs7uxeyl5yJnsn_vfNcbVUwaeQfL_5JjOfEC8RzhCgfpsQtdYloCylrGUJT8QMK1qUiJKeihkA6FIT_jgWJynd5qtUFT0Tx6QI1YJoJr7crLhYrqwfnB-KC16HIdrNyrWpCH3x2TMXFy6NobWTC_5dcV584ymGtOF2crss2sk2NnF-3jn-9Vwc9XZM_OL-PBXfLz_cLD-W11-vPi3Pr8u2AjmVXd03qpO2mWsi3SjZIUiWoOtFrTpVE1VUQ9OrDluFC-r6-Vw1wJ2FvqHOylPx_uC72TZr7lr2U7Sj2US3tvG3CdaZvxXvVmYIO6MQa42UDd7cG8Twc8tpMmuXWh5H6zlsk8GqQqC8rT36-h_0Nmyjz-PtqZwDSF1lCg9Um7eTIvcPn0Ew-7TMIS2T0zL7tAzkmlePp3io-BNPBugApCz5geOj1v91vQO1RJ85</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Arom, Gabriel A.</creator><creator>Yeranosian, Michael G.</creator><creator>Petrigliano, Frank A.</creator><creator>Terrell, Rodney D.</creator><creator>McAllister, David R.</creator><general>Springer US</general><general>Lippincott Williams &amp; Wilkins Ovid Technologies</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140901</creationdate><title>The Changing Demographics of Knee Dislocation: A Retrospective Database Review</title><author>Arom, Gabriel A. ; Yeranosian, Michael G. ; Petrigliano, Frank A. ; Terrell, Rodney D. ; McAllister, David R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-d7fb4d3ab69229b43d103e3097874d47225270bf4d1c4182df664b0eda0fb2da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Child</topic><topic>Conservative Orthopedics</topic><topic>Databases, Factual</topic><topic>Demography - trends</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Knee</topic><topic>Knee Dislocation - epidemiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Middle Aged</topic><topic>Orthopedics</topic><topic>Orthopedics - statistics &amp; numerical data</topic><topic>Retrospective Studies</topic><topic>Sex Distribution</topic><topic>Sports Medicine</topic><topic>Surgery</topic><topic>Surgical Orthopedics</topic><topic>Symposium: Management of the Dislocated Knee</topic><topic>United States - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arom, Gabriel A.</creatorcontrib><creatorcontrib>Yeranosian, Michael G.</creatorcontrib><creatorcontrib>Petrigliano, Frank A.</creatorcontrib><creatorcontrib>Terrell, Rodney D.</creatorcontrib><creatorcontrib>McAllister, David R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical orthopaedics and related research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arom, Gabriel A.</au><au>Yeranosian, Michael G.</au><au>Petrigliano, Frank A.</au><au>Terrell, Rodney D.</au><au>McAllister, David R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Changing Demographics of Knee Dislocation: A Retrospective Database Review</atitle><jtitle>Clinical orthopaedics and related research</jtitle><stitle>Clin Orthop Relat Res</stitle><addtitle>Clin Orthop Relat Res</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>472</volume><issue>9</issue><spage>2609</spage><epage>2614</epage><pages>2609-2614</pages><issn>0009-921X</issn><eissn>1528-1132</eissn><abstract>Background Knee dislocations are uncommon but devastating orthopaedic injuries. Little is known about their frequency and the types of patients who are affected. Questions/purposes Using a large national insurance database, we determined (1) the incidence of knee dislocation in patients with orthopaedic injuries and examined the incidence as a function of (2) year of diagnosis, (3) dislocation type (open versus closed, direction), and (4) patient demographic factors (sex, age). Methods We searched the PearlDiver database, a national database of private insurance records consisting of 11 million patients with orthopaedic diagnoses, using diagnosis (ICD-9-CM) codes for knee dislocation between the years 2004 and 2009. The PearlDiver database does not include Medicare, Medicaid, or uninsured patients. Patients were stratified by age, sex, and year of diagnosis. Incidence was defined as the number of dislocation events per 100 patient-years. Results We identified 8050 dislocations, representing an incidence of 0.072 events per 100 patient-years between 2004 and 2009. Annual dislocation incidence did not increase during the 6-year study period. Of the 8050 dislocations, 1333 (17%) were open and 6717 (83%) were closed, representing an incidence of 0.060 per 100 for closed dislocations and 0.012 per 100 for open dislocations. The most common direction of dislocation was unspecified or other (65%), followed by anterior (13%), lateral (11%), posterior (6%), and medial (5%). Of the patients sustaining dislocations, 4172 (52%) were female and 3878 (48%) were male. Males displayed an increased risk of knee dislocation compared to females (odds ratio = 1.09). The mean patient age was 35 years, and patient age was inversely correlated to the incidence of knee dislocation (10-year odds ratio = 0.77). Conclusions Our data suggest that knee dislocation might represent a significantly larger burden among orthopaedic injuries than previously thought. The finding that males and females have a nearly equal risk of knee dislocation enhances the diagnosing physician’s clinical suspicion of this injury. Future large prospective studies analyzing the various causes of knee dislocation could provide insight into the changing demographics of this injury. Level of Evidence Level IV, prognostic study. See Instructions for Authors for a complete description of levels of evidence.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24214822</pmid><doi>10.1007/s11999-013-3373-0</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0009-921X
ispartof Clinical orthopaedics and related research, 2014-09, Vol.472 (9), p.2609-2614
issn 0009-921X
1528-1132
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4117912
source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SpringerLink Journals - AutoHoldings
subjects Adolescent
Adult
Age Distribution
Aged
Child
Conservative Orthopedics
Databases, Factual
Demography - trends
Female
Humans
Incidence
Knee
Knee Dislocation - epidemiology
Male
Medicine
Medicine & Public Health
Middle Aged
Orthopedics
Orthopedics - statistics & numerical data
Retrospective Studies
Sex Distribution
Sports Medicine
Surgery
Surgical Orthopedics
Symposium: Management of the Dislocated Knee
United States - epidemiology
Young Adult
title The Changing Demographics of Knee Dislocation: A Retrospective Database Review
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T02%3A28%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Changing%20Demographics%20of%20Knee%20Dislocation:%20A%20Retrospective%20Database%20Review&rft.jtitle=Clinical%20orthopaedics%20and%20related%20research&rft.au=Arom,%20Gabriel%20A.&rft.date=2014-09-01&rft.volume=472&rft.issue=9&rft.spage=2609&rft.epage=2614&rft.pages=2609-2614&rft.issn=0009-921X&rft.eissn=1528-1132&rft_id=info:doi/10.1007/s11999-013-3373-0&rft_dat=%3Cproquest_pubme%3E1551024522%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1550070395&rft_id=info:pmid/24214822&rfr_iscdi=true