Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum
Objective The glands of the stomach body and antral mucosa contain a complex compendium of cell lineages. In lower mammals, the distribution of oxyntic glands and antral glands define the anatomical regions within the stomach. We examined in detail the distribution of the full range of cell lineages...
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| Veröffentlicht in: | Gut 2014-11, Vol.63 (11), p.1711-1720 |
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| creator | Choi, Eunyoung Roland, Joseph T Barlow, Brittney J O'Neal, Ryan Rich, Amy E Nam, Ki Taek Shi, Chanjuan Goldenring, James R |
| description | Objective The glands of the stomach body and antral mucosa contain a complex compendium of cell lineages. In lower mammals, the distribution of oxyntic glands and antral glands define the anatomical regions within the stomach. We examined in detail the distribution of the full range of cell lineages within the human stomach. Design We determined the distribution of gastric gland cell lineages with specific immunocytochemical markers in entire stomach specimens from three non-obese organ donors. Results The anatomical body and antrum of the human stomach were defined by the presence of ghrelin and gastrin cells, respectively. Concentrations of somatostatin cells were observed in the proximal stomach. Parietal cells were seen in all glands of the body of the stomach as well as in over 50% of antral glands. MIST1 expressing chief cells were predominantly observed in the body although individual glands of the antrum also showed MIST1 expressing chief cells. While classically described antral glands were observed with gastrin cells and deep antral mucous cells without any parietal cells, we also observed a substantial population of mixed type glands containing both parietal cells and G cells throughout the antrum. Conclusions Enteroendocrine cells show distinct patterns of localisation in the human stomach. The existence of antral glands with mixed cell lineages indicates that human antral glands may be functionally chimeric with glands assembled from multiple distinct stem cell populations. |
| doi_str_mv | 10.1136/gutjnl-2013-305964 |
| format | Article |
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In lower mammals, the distribution of oxyntic glands and antral glands define the anatomical regions within the stomach. We examined in detail the distribution of the full range of cell lineages within the human stomach. Design We determined the distribution of gastric gland cell lineages with specific immunocytochemical markers in entire stomach specimens from three non-obese organ donors. Results The anatomical body and antrum of the human stomach were defined by the presence of ghrelin and gastrin cells, respectively. Concentrations of somatostatin cells were observed in the proximal stomach. Parietal cells were seen in all glands of the body of the stomach as well as in over 50% of antral glands. MIST1 expressing chief cells were predominantly observed in the body although individual glands of the antrum also showed MIST1 expressing chief cells. While classically described antral glands were observed with gastrin cells and deep antral mucous cells without any parietal cells, we also observed a substantial population of mixed type glands containing both parietal cells and G cells throughout the antrum. Conclusions Enteroendocrine cells show distinct patterns of localisation in the human stomach. The existence of antral glands with mixed cell lineages indicates that human antral glands may be functionally chimeric with glands assembled from multiple distinct stem cell populations.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>DOI: 10.1136/gutjnl-2013-305964</identifier><identifier>PMID: 24488499</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Arrays ; Cell Lineage ; Cells ; Enteroendocrine Cells - metabolism ; Gastric Mucosa - cytology ; Gastric Mucosa - metabolism ; Gastrins - metabolism ; Ghrelin - metabolism ; Humans ; Immunohistochemistry ; Mapping ; Parietal Cells, Gastric - cytology ; Parietal Cells, Gastric - metabolism ; Pyloric Antrum - cytology ; Pyloric Antrum - metabolism ; Somatostatin - metabolism ; Stomach ; Stomach - cytology ; Stomach - metabolism</subject><ispartof>Gut, 2014-11, Vol.63 (11), p.1711-1720</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2014 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b637t-57dfd7743acbb22695a6b103430b92f46e0f877eaec9498bf6823493958da32d3</citedby><cites>FETCH-LOGICAL-b637t-57dfd7743acbb22695a6b103430b92f46e0f877eaec9498bf6823493958da32d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://gut.bmj.com/content/63/11/1711.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://gut.bmj.com/content/63/11/1711.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,315,728,781,785,886,3197,23576,27929,27930,53796,53798,77605,77636</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24488499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Eunyoung</creatorcontrib><creatorcontrib>Roland, Joseph T</creatorcontrib><creatorcontrib>Barlow, Brittney J</creatorcontrib><creatorcontrib>O'Neal, Ryan</creatorcontrib><creatorcontrib>Rich, Amy E</creatorcontrib><creatorcontrib>Nam, Ki Taek</creatorcontrib><creatorcontrib>Shi, Chanjuan</creatorcontrib><creatorcontrib>Goldenring, James R</creatorcontrib><title>Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum</title><title>Gut</title><addtitle>Gut</addtitle><description>Objective The glands of the stomach body and antral mucosa contain a complex compendium of cell lineages. In lower mammals, the distribution of oxyntic glands and antral glands define the anatomical regions within the stomach. We examined in detail the distribution of the full range of cell lineages within the human stomach. Design We determined the distribution of gastric gland cell lineages with specific immunocytochemical markers in entire stomach specimens from three non-obese organ donors. Results The anatomical body and antrum of the human stomach were defined by the presence of ghrelin and gastrin cells, respectively. Concentrations of somatostatin cells were observed in the proximal stomach. Parietal cells were seen in all glands of the body of the stomach as well as in over 50% of antral glands. MIST1 expressing chief cells were predominantly observed in the body although individual glands of the antrum also showed MIST1 expressing chief cells. While classically described antral glands were observed with gastrin cells and deep antral mucous cells without any parietal cells, we also observed a substantial population of mixed type glands containing both parietal cells and G cells throughout the antrum. Conclusions Enteroendocrine cells show distinct patterns of localisation in the human stomach. The existence of antral glands with mixed cell lineages indicates that human antral glands may be functionally chimeric with glands assembled from multiple distinct stem cell populations.</description><subject>Arrays</subject><subject>Cell Lineage</subject><subject>Cells</subject><subject>Enteroendocrine Cells - metabolism</subject><subject>Gastric Mucosa - cytology</subject><subject>Gastric Mucosa - metabolism</subject><subject>Gastrins - metabolism</subject><subject>Ghrelin - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Mapping</subject><subject>Parietal Cells, Gastric - cytology</subject><subject>Parietal Cells, Gastric - metabolism</subject><subject>Pyloric Antrum - cytology</subject><subject>Pyloric Antrum - metabolism</subject><subject>Somatostatin - metabolism</subject><subject>Stomach</subject><subject>Stomach - cytology</subject><subject>Stomach - metabolism</subject><issn>0017-5749</issn><issn>1468-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkctu1DAYhS1ERYfCC7BAltiwCfUtvmyQ0IibVIlNu7acxEk8cuzBdirx9ngmpQJWXXnh73z2_x8A3mD0AWPKr6e1HIJvCMK0oahVnD0DO8y4bCiR8jnYIYRF0wqmLsHLnA8IISkVfgEuCWNSMqV2IO2t99C7YM1k4eBySa5bi4sBmuJNhnGEZbZwXhcTYC5xMf0Mk723xmc422JTnGywcc1w8iYM8BiPqzcnQ4YunMOTOWl7aEJJ6_IKXIw1bF8_nFfg7svn2_235ubH1-_7TzdNx6ko9d_DOAjBqOm7jhCuWsM7jCijqFNkZNyiUQphje0VU7IbuSSUKapaORhKBnoFPm7e49otduhtfd14fUxuMemXjsbpf2-Cm_UU7zXDWFRXFbx_EKT4c7W56MXlvu7LnOfVWCLJiRLtE9BWcowQR6Si7_5DD3FNoW5CYyEU4606U2Sj-hRzTnZ8_DdG-tS-3trXp_b11n4Nvf174sfIn7or0GxAtxyeIvwNi569FA</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Choi, Eunyoung</creator><creator>Roland, Joseph T</creator><creator>Barlow, Brittney J</creator><creator>O'Neal, Ryan</creator><creator>Rich, Amy E</creator><creator>Nam, Ki Taek</creator><creator>Shi, Chanjuan</creator><creator>Goldenring, James R</creator><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20141101</creationdate><title>Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum</title><author>Choi, Eunyoung ; Roland, Joseph T ; Barlow, Brittney J ; O'Neal, Ryan ; Rich, Amy E ; Nam, Ki Taek ; Shi, Chanjuan ; Goldenring, James R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b637t-57dfd7743acbb22695a6b103430b92f46e0f877eaec9498bf6823493958da32d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Arrays</topic><topic>Cell Lineage</topic><topic>Cells</topic><topic>Enteroendocrine Cells - metabolism</topic><topic>Gastric Mucosa - cytology</topic><topic>Gastric Mucosa - metabolism</topic><topic>Gastrins - metabolism</topic><topic>Ghrelin - metabolism</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Mapping</topic><topic>Parietal Cells, Gastric - cytology</topic><topic>Parietal Cells, Gastric - metabolism</topic><topic>Pyloric Antrum - cytology</topic><topic>Pyloric Antrum - metabolism</topic><topic>Somatostatin - metabolism</topic><topic>Stomach</topic><topic>Stomach - cytology</topic><topic>Stomach - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Eunyoung</creatorcontrib><creatorcontrib>Roland, Joseph T</creatorcontrib><creatorcontrib>Barlow, Brittney J</creatorcontrib><creatorcontrib>O'Neal, Ryan</creatorcontrib><creatorcontrib>Rich, Amy E</creatorcontrib><creatorcontrib>Nam, Ki Taek</creatorcontrib><creatorcontrib>Shi, Chanjuan</creatorcontrib><creatorcontrib>Goldenring, James R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Eunyoung</au><au>Roland, Joseph T</au><au>Barlow, Brittney J</au><au>O'Neal, Ryan</au><au>Rich, Amy E</au><au>Nam, Ki Taek</au><au>Shi, Chanjuan</au><au>Goldenring, James R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>63</volume><issue>11</issue><spage>1711</spage><epage>1720</epage><pages>1711-1720</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><coden>GUTTAK</coden><abstract>Objective The glands of the stomach body and antral mucosa contain a complex compendium of cell lineages. In lower mammals, the distribution of oxyntic glands and antral glands define the anatomical regions within the stomach. We examined in detail the distribution of the full range of cell lineages within the human stomach. Design We determined the distribution of gastric gland cell lineages with specific immunocytochemical markers in entire stomach specimens from three non-obese organ donors. Results The anatomical body and antrum of the human stomach were defined by the presence of ghrelin and gastrin cells, respectively. Concentrations of somatostatin cells were observed in the proximal stomach. Parietal cells were seen in all glands of the body of the stomach as well as in over 50% of antral glands. MIST1 expressing chief cells were predominantly observed in the body although individual glands of the antrum also showed MIST1 expressing chief cells. While classically described antral glands were observed with gastrin cells and deep antral mucous cells without any parietal cells, we also observed a substantial population of mixed type glands containing both parietal cells and G cells throughout the antrum. Conclusions Enteroendocrine cells show distinct patterns of localisation in the human stomach. The existence of antral glands with mixed cell lineages indicates that human antral glands may be functionally chimeric with glands assembled from multiple distinct stem cell populations.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>24488499</pmid><doi>10.1136/gutjnl-2013-305964</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Arrays Cell Lineage Cells Enteroendocrine Cells - metabolism Gastric Mucosa - cytology Gastric Mucosa - metabolism Gastrins - metabolism Ghrelin - metabolism Humans Immunohistochemistry Mapping Parietal Cells, Gastric - cytology Parietal Cells, Gastric - metabolism Pyloric Antrum - cytology Pyloric Antrum - metabolism Somatostatin - metabolism Stomach Stomach - cytology Stomach - metabolism |
| title | Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum |
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