Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III
Objective: Bayley-III scales are currently used to evaluate outcomes of term infants following hypothermia therapy, while all before reported outcomes in this population have used Bayley-II. Our objectives were to determine the incidence of abnormal neurodevelopmental outcomes using Bayley III and t...
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| Veröffentlicht in: | Journal of perinatology 2014-08, Vol.34 (8), p.629-633 |
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| container_title | Journal of perinatology |
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| creator | Chalak, L F DuPont, T L Sánchez, P J Lucke, A Heyne, R J Morriss, M C Rollins, N K |
| description | Objective:
Bayley-III scales are currently used to evaluate outcomes of term infants following hypothermia therapy, while all before reported outcomes in this population have used Bayley-II. Our objectives were to determine the incidence of abnormal neurodevelopmental outcomes using Bayley III and the predictive value of Magnetic resonance imaging (MRI) in infants who received systemic hypothermia.
Study Design:
We conducted a prospective cohort study of inborn infants who underwent hypothermia for moderate/severe neonatal encephalopathy from October 2005–November 2011.
Result:
Eighty newborns underwent hypothermia (incidence of 1/1000). Of the survivors, 89% had Bayley-III performed around 24 months of age. An abnormal outcome using Bayley-III |
| doi_str_mv | 10.1038/jp.2014.67 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4117736</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A380748360</galeid><sourcerecordid>A380748360</sourcerecordid><originalsourceid>FETCH-LOGICAL-c638t-c2ddd5db16129cd95cb84dbeced6c2cd93f30d0b2572f18141411f719073a363</originalsourceid><addsrcrecordid>eNp9kl2L1DAUhoMo7uzqjT9ACoIsSsd8Nu2NsC5-DCzrzd6HNDmd6ZA2NWkX-u9NnXWZUZFzkY_3OW-Sk4PQK4LXBLPyw35YU0z4upBP0IpwWeRCcPYUrbDkLC8ZL87QeYx7jBdRPkdnlCeFMLZCt7cwBW_hHpwfOuhH7TI_jcZ3EDPdjBCy3Tz4cQeha3W2jHqYs7ZfpllaZL7JPunZwZxvNpsX6FmjXYSXD-MFuvvy-e76W37z_evm-uomNwUrx9xQa62wNSkIrYythKlLbmswYAtD0wZrGLa4pkLShpSEpyCNJBWWTLOCXaCPB9thqjuwJt07aKeG0HY6zMrrVp0qfbtTW3-vko2UvwwuHwyC_zFBHFXXRgPO6R78FBURAmNZ8hIn9M0f6N5PoU-vU7TgWEhRVdX_KCJ4RQWh8shrqx2otm98up1ZjlZXrEzfVbJiodb_oFJY6Frje2jatH-S8PYoYQfajbvo3TS2vo-n4LsDaIKPMUDzWDKC1dJLaj-opZdUIRP8-rjIj-jv5knA-wMQk9RvIRy9-W-7nwddz_A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1549251270</pqid></control><display><type>article</type><title>Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Chalak, L F ; DuPont, T L ; Sánchez, P J ; Lucke, A ; Heyne, R J ; Morriss, M C ; Rollins, N K</creator><creatorcontrib>Chalak, L F ; DuPont, T L ; Sánchez, P J ; Lucke, A ; Heyne, R J ; Morriss, M C ; Rollins, N K</creatorcontrib><description>Objective:
Bayley-III scales are currently used to evaluate outcomes of term infants following hypothermia therapy, while all before reported outcomes in this population have used Bayley-II. Our objectives were to determine the incidence of abnormal neurodevelopmental outcomes using Bayley III and the predictive value of Magnetic resonance imaging (MRI) in infants who received systemic hypothermia.
Study Design:
We conducted a prospective cohort study of inborn infants who underwent hypothermia for moderate/severe neonatal encephalopathy from October 2005–November 2011.
Result:
Eighty newborns underwent hypothermia (incidence of 1/1000). Of the survivors, 89% had Bayley-III performed around 24 months of age. An abnormal outcome using Bayley-III <85 occurred in 50%, while Bayley III <70 occurred in 13%. MRI predicted Bayley III<85 with sensitivity of 73%, specificity of 84%, positive-predictive value of 84% and negative-predictive value of 74%.
Conclusion:
A Bayley-III 85 cutoff identifies a disability rate of 50%, and MRI was predictive of abnormal outcomes. Findings can be useful for counseling of families and planning of future studies using Bayley III.</description><identifier>ISSN: 0743-8346</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/jp.2014.67</identifier><identifier>PMID: 24743133</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/699/375/3183 ; 692/699/375/366 ; 692/700/1720/3186 ; 692/700/565 ; Care and treatment ; Cerebral palsy ; Child Development ; Cohort analysis ; Cohort Studies ; Developmental Disabilities - diagnosis ; Developmental Disabilities - etiology ; Encephalopathy ; Female ; Health aspects ; Humans ; Hypothermia ; Hypothermia, Induced ; Hypoxia-Ischemia, Brain - complications ; Hypoxia-Ischemia, Brain - psychology ; Hypoxia-Ischemia, Brain - therapy ; Infant ; Infant, Newborn ; Infants ; Magnetic Resonance Imaging ; Male ; Medicine ; Medicine & Public Health ; Neonates ; original-article ; Outcome Assessment (Health Care) ; Patient outcomes ; Pediatric Surgery ; Pediatrics ; Predictive Value of Tests ; Traumatic brain injury ; Umbilical cord</subject><ispartof>Journal of perinatology, 2014-08, Vol.34 (8), p.629-633</ispartof><rights>Nature America, Inc. 2014</rights><rights>COPYRIGHT 2014 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Aug 2014</rights><rights>Nature America, Inc. 2014.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c638t-c2ddd5db16129cd95cb84dbeced6c2cd93f30d0b2572f18141411f719073a363</citedby><cites>FETCH-LOGICAL-c638t-c2ddd5db16129cd95cb84dbeced6c2cd93f30d0b2572f18141411f719073a363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/jp.2014.67$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/jp.2014.67$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24743133$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chalak, L F</creatorcontrib><creatorcontrib>DuPont, T L</creatorcontrib><creatorcontrib>Sánchez, P J</creatorcontrib><creatorcontrib>Lucke, A</creatorcontrib><creatorcontrib>Heyne, R J</creatorcontrib><creatorcontrib>Morriss, M C</creatorcontrib><creatorcontrib>Rollins, N K</creatorcontrib><title>Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective:
Bayley-III scales are currently used to evaluate outcomes of term infants following hypothermia therapy, while all before reported outcomes in this population have used Bayley-II. Our objectives were to determine the incidence of abnormal neurodevelopmental outcomes using Bayley III and the predictive value of Magnetic resonance imaging (MRI) in infants who received systemic hypothermia.
Study Design:
We conducted a prospective cohort study of inborn infants who underwent hypothermia for moderate/severe neonatal encephalopathy from October 2005–November 2011.
Result:
Eighty newborns underwent hypothermia (incidence of 1/1000). Of the survivors, 89% had Bayley-III performed around 24 months of age. An abnormal outcome using Bayley-III <85 occurred in 50%, while Bayley III <70 occurred in 13%. MRI predicted Bayley III<85 with sensitivity of 73%, specificity of 84%, positive-predictive value of 84% and negative-predictive value of 74%.
Conclusion:
A Bayley-III 85 cutoff identifies a disability rate of 50%, and MRI was predictive of abnormal outcomes. Findings can be useful for counseling of families and planning of future studies using Bayley III.</description><subject>692/699/375/3183</subject><subject>692/699/375/366</subject><subject>692/700/1720/3186</subject><subject>692/700/565</subject><subject>Care and treatment</subject><subject>Cerebral palsy</subject><subject>Child Development</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Developmental Disabilities - diagnosis</subject><subject>Developmental Disabilities - etiology</subject><subject>Encephalopathy</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hypothermia</subject><subject>Hypothermia, Induced</subject><subject>Hypoxia-Ischemia, Brain - complications</subject><subject>Hypoxia-Ischemia, Brain - psychology</subject><subject>Hypoxia-Ischemia, Brain - therapy</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neonates</subject><subject>original-article</subject><subject>Outcome Assessment (Health Care)</subject><subject>Patient outcomes</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Predictive Value of Tests</subject><subject>Traumatic brain injury</subject><subject>Umbilical cord</subject><issn>0743-8346</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kl2L1DAUhoMo7uzqjT9ACoIsSsd8Nu2NsC5-DCzrzd6HNDmd6ZA2NWkX-u9NnXWZUZFzkY_3OW-Sk4PQK4LXBLPyw35YU0z4upBP0IpwWeRCcPYUrbDkLC8ZL87QeYx7jBdRPkdnlCeFMLZCt7cwBW_hHpwfOuhH7TI_jcZ3EDPdjBCy3Tz4cQeha3W2jHqYs7ZfpllaZL7JPunZwZxvNpsX6FmjXYSXD-MFuvvy-e76W37z_evm-uomNwUrx9xQa62wNSkIrYythKlLbmswYAtD0wZrGLa4pkLShpSEpyCNJBWWTLOCXaCPB9thqjuwJt07aKeG0HY6zMrrVp0qfbtTW3-vko2UvwwuHwyC_zFBHFXXRgPO6R78FBURAmNZ8hIn9M0f6N5PoU-vU7TgWEhRVdX_KCJ4RQWh8shrqx2otm98up1ZjlZXrEzfVbJiodb_oFJY6Frje2jatH-S8PYoYQfajbvo3TS2vo-n4LsDaIKPMUDzWDKC1dJLaj-opZdUIRP8-rjIj-jv5knA-wMQk9RvIRy9-W-7nwddz_A</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Chalak, L F</creator><creator>DuPont, T L</creator><creator>Sánchez, P J</creator><creator>Lucke, A</creator><creator>Heyne, R J</creator><creator>Morriss, M C</creator><creator>Rollins, N K</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140801</creationdate><title>Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III</title><author>Chalak, L F ; DuPont, T L ; Sánchez, P J ; Lucke, A ; Heyne, R J ; Morriss, M C ; Rollins, N K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c638t-c2ddd5db16129cd95cb84dbeced6c2cd93f30d0b2572f18141411f719073a363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>692/699/375/3183</topic><topic>692/699/375/366</topic><topic>692/700/1720/3186</topic><topic>692/700/565</topic><topic>Care and treatment</topic><topic>Cerebral palsy</topic><topic>Child Development</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Developmental Disabilities - diagnosis</topic><topic>Developmental Disabilities - etiology</topic><topic>Encephalopathy</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hypothermia</topic><topic>Hypothermia, Induced</topic><topic>Hypoxia-Ischemia, Brain - complications</topic><topic>Hypoxia-Ischemia, Brain - psychology</topic><topic>Hypoxia-Ischemia, Brain - therapy</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neonates</topic><topic>original-article</topic><topic>Outcome Assessment (Health Care)</topic><topic>Patient outcomes</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Predictive Value of Tests</topic><topic>Traumatic brain injury</topic><topic>Umbilical cord</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chalak, L F</creatorcontrib><creatorcontrib>DuPont, T L</creatorcontrib><creatorcontrib>Sánchez, P J</creatorcontrib><creatorcontrib>Lucke, A</creatorcontrib><creatorcontrib>Heyne, R J</creatorcontrib><creatorcontrib>Morriss, M C</creatorcontrib><creatorcontrib>Rollins, N K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chalak, L F</au><au>DuPont, T L</au><au>Sánchez, P J</au><au>Lucke, A</au><au>Heyne, R J</au><au>Morriss, M C</au><au>Rollins, N K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>34</volume><issue>8</issue><spage>629</spage><epage>633</epage><pages>629-633</pages><issn>0743-8346</issn><eissn>1476-5543</eissn><abstract>Objective:
Bayley-III scales are currently used to evaluate outcomes of term infants following hypothermia therapy, while all before reported outcomes in this population have used Bayley-II. Our objectives were to determine the incidence of abnormal neurodevelopmental outcomes using Bayley III and the predictive value of Magnetic resonance imaging (MRI) in infants who received systemic hypothermia.
Study Design:
We conducted a prospective cohort study of inborn infants who underwent hypothermia for moderate/severe neonatal encephalopathy from October 2005–November 2011.
Result:
Eighty newborns underwent hypothermia (incidence of 1/1000). Of the survivors, 89% had Bayley-III performed around 24 months of age. An abnormal outcome using Bayley-III <85 occurred in 50%, while Bayley III <70 occurred in 13%. MRI predicted Bayley III<85 with sensitivity of 73%, specificity of 84%, positive-predictive value of 84% and negative-predictive value of 74%.
Conclusion:
A Bayley-III 85 cutoff identifies a disability rate of 50%, and MRI was predictive of abnormal outcomes. Findings can be useful for counseling of families and planning of future studies using Bayley III.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>24743133</pmid><doi>10.1038/jp.2014.67</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/699/375/3183 692/699/375/366 692/700/1720/3186 692/700/565 Care and treatment Cerebral palsy Child Development Cohort analysis Cohort Studies Developmental Disabilities - diagnosis Developmental Disabilities - etiology Encephalopathy Female Health aspects Humans Hypothermia Hypothermia, Induced Hypoxia-Ischemia, Brain - complications Hypoxia-Ischemia, Brain - psychology Hypoxia-Ischemia, Brain - therapy Infant Infant, Newborn Infants Magnetic Resonance Imaging Male Medicine Medicine & Public Health Neonates original-article Outcome Assessment (Health Care) Patient outcomes Pediatric Surgery Pediatrics Predictive Value of Tests Traumatic brain injury Umbilical cord |
| title | Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III |
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