Retinoid Prevents Mammary Gland Transformation by Carcinogenic Hydrocarbon in Whole-Organ Culture

The mouse mammary gland in whole-organ culture, an in vitro system that is capable of alveolar development, differentiation, involution, and oncogenic transformation, has been used to examine the effects of the retinoid 2-retinylidene-5,5-dimethyl-1,3-cyclohexanedione (retinylidene dimedone) on epit...

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Veröffentlicht in:	Proc. Natl. Acad. Sci. U.S.A.; (United States) 1979-11, Vol.76 (11), p.5891-5895
Hauptverfasser:	Dickens, Michael S., Custer, R. Philip, Sorof, Sam
Format:	Artikel
Sprache:	eng
Schlagworte:	560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987) 9,10-Dimethyl-1,2-benzanthracene - antagonists & inhibitors Adipose tissues Animal glands ANIMALS AROMATICS BENZANTHRACENE BIOLOGICAL EFFECTS BIOLOGICAL MODELS BODY CARCINOGENESIS Carcinogens CAROTENOIDS Cell Transformation, Neoplastic - drug effects CONDENSED AROMATICS DOSE-RESPONSE RELATIONSHIPS Female GLANDS HYDROCARBONS MAMMALS MAMMARY GLANDS Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - prevention & control MICE Mice, Inbred BALB C Mouse mammary tumor virus Murine sarcoma viruses Organ Culture Techniques ORGANIC COMPOUNDS ORGANS PATHOGENESIS Phenotypes PIGMENTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RESPONSE MODIFYING FACTORS Retinoids RODENTS Solvents Sulfoxides TERPENES TISSUE CULTURES TOLERANCE VERTEBRATES Vitamin A - analogs & derivatives Vitamin A - pharmacology
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