Snail regulates Nanog status during the epithelial-mesenchymal transition via the Smad1/Akt/GSK3β signaling pathway in non-small-cell lung cancer

The epithelial-mesenchymal transition (EMT), a crucial step in cancer metastasis, is important in transformed cancer cells with stem cell-like properties. In this study, we established a Snail-overexpressing cell model for non-small-cell lung cancer (NSCLC) and investigated its underlying mechanism....

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Veröffentlicht in:	Oncotarget 2014-06, Vol.5 (11), p.3880-3894
Hauptverfasser:	Liu, Chen-Wei, Li, Ching-Hao, Peng, Yi-Jen, Cheng, Yu-Wen, Chen, Huei-Wen, Liao, Po-Lin, Kang, Jaw-Jou, Yeng, Mao-Hsiung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Epithelial-Mesenchymal Transition - physiology Female Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Heterografts Homeodomain Proteins - metabolism Humans Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Mice Mice, Inbred BALB C Mice, SCID Middle Aged Nanog Homeobox Protein Neoplastic Stem Cells - pathology Proto-Oncogene Proteins c-akt - metabolism Research Paper Signal Transduction Smad1 Protein - metabolism Snail Family Transcription Factors Transcription Factors - antagonists & inhibitors Transcription Factors - metabolism Transfection
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