Interleukin-15 Expression Is Increased in Human Eosinophilic Esophagitis and Mediates Pathogenesis in Mice

Background & Aims Quantitative microarray analyses have shown increased expression of interleukin-15 ( IL-15 ) messenger RNA in the esophagus of patients with eosinophilic esophagitis (EoE), a recently recognized allergic disorder with poorly understood pathogenesis. Methods Quantitative polymer...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2010-07, Vol.139 (1), p.182-193.e7
Hauptverfasser:	Zhu, Xiang, Wang, Meiqin, Mavi, Parm, Rayapudi, Madhavi, Pandey, Akhilesh K, Kaul, Ajay, Putnam, Philip E, Rothenberg, Marc E, Mishra, Anil
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Animals CD4-Positive T-Lymphocytes - immunology Child Child, Preschool EoE Patients Eosinophilia - etiology Esophagitis - etiology Esophagus Female Gastroenterology and Hepatology Humans IL-15Ra Infant Interleukin-15 - analysis Interleukin-15 - genetics Interleukin-15 - physiology Male Mice Mice, Inbred BALB C Receptors, Interleukin-15 - physiology T Cells
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