Development and validation of a lung transplant-specific disability questionnaire
Background Lung transplant (LT) aims to extend survival and improve patient-centred outcomes (PCOs) by reducing disability and improving health-related quality of life (HRQL). Few PCO instruments have been validated in LT populations. We aimed to develop and validate a shortened version of the value...
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| Veröffentlicht in: | Thorax 2014-05, Vol.69 (5), p.445-450 |
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| creator | Singer, Jonathan Paul Blanc, Paul David Dean, Y Monica Hays, Steven Leard, Lorriana Kukreja, Jasleen Golden, Jeffrey Katz, Patricia P |
| description | Background Lung transplant (LT) aims to extend survival and improve patient-centred outcomes (PCOs) by reducing disability and improving health-related quality of life (HRQL). Few PCO instruments have been validated in LT populations. We aimed to develop and validate a shortened version of the valued life activities (VLA) disability scale specific to LT. Methods We used data from 140 subjects participating in an ongoing cohort study of LT. Subjects completed a survey battery, including VLA items, and physical assessments before LT. To develop a shortened LT-specific VLA (LT-VLA), we iteratively deleted items from a longer 32-item VLA battery, retaining the instrument's conceptual framework, scoring and performance characteristics. We evaluated LT-VLA validity by testing correlations with a HRQL measure (Short Form-12 Physical Function (SF-12 PF) subscale), forced vital capacity % (FVC%) predicted and 6 minute walk distance (6MWD). Responsiveness was evaluated in 84 subjects who completed assessments before and after LT. Results The 15-item LT-VLA scoring closely matched the longer VLA (correlations ≥0.96) and had excellent internal consistency (Cronbach's α 0.92). The LT-VLA required only 3 min or less to administer. The LT-VLA, measured as mean difficulty in performing each of the 15 activities queried, correlated with FVC% predicted (r=−0.30), 6MWD (r=−0.38) and SF-12 PF (r=−0.47) (all p |
| doi_str_mv | 10.1136/thoraxjnl-2013-204557 |
| format | Article |
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Few PCO instruments have been validated in LT populations. We aimed to develop and validate a shortened version of the valued life activities (VLA) disability scale specific to LT. Methods We used data from 140 subjects participating in an ongoing cohort study of LT. Subjects completed a survey battery, including VLA items, and physical assessments before LT. To develop a shortened LT-specific VLA (LT-VLA), we iteratively deleted items from a longer 32-item VLA battery, retaining the instrument's conceptual framework, scoring and performance characteristics. We evaluated LT-VLA validity by testing correlations with a HRQL measure (Short Form-12 Physical Function (SF-12 PF) subscale), forced vital capacity % (FVC%) predicted and 6 minute walk distance (6MWD). Responsiveness was evaluated in 84 subjects who completed assessments before and after LT. Results The 15-item LT-VLA scoring closely matched the longer VLA (correlations ≥0.96) and had excellent internal consistency (Cronbach's α 0.92). The LT-VLA required only 3 min or less to administer. The LT-VLA, measured as mean difficulty in performing each of the 15 activities queried, correlated with FVC% predicted (r=−0.30), 6MWD (r=−0.38) and SF-12 PF (r=−0.47) (all p<0.01). The LT-VLA mean difficulty was responsive to change from before to after LT (63% improvement; effect size=1.60). Conclusions The LT-VLA is a short, easy to administer, valid and responsive disease-specific PCO instrument that may be useful in clinical and research applications for lung transplantation.</description><identifier>ISSN: 0040-6376</identifier><identifier>EISSN: 1468-3296</identifier><identifier>DOI: 10.1136/thoraxjnl-2013-204557</identifier><identifier>PMID: 24355825</identifier><identifier>CODEN: THORA7</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Activities of daily living ; Chronic obstructive pulmonary disease ; Disability ; Disability Evaluation ; Disabled Persons - psychology ; Disabled Persons - statistics & numerical data ; Female ; Forced Expiratory Volume ; Humans ; Lung - physiopathology ; Lung diseases ; Lung Transplantation - rehabilitation ; Male ; Middle Aged ; Outcome Assessment (Health Care) - methods ; Patients ; Quality of Life ; Reproducibility of Results ; Studies ; Surveys and Questionnaires ; Transplants & implants ; Vital Capacity ; Walking - physiology</subject><ispartof>Thorax, 2014-05, Vol.69 (5), p.445-450</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2014 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b616t-b4db86fec2bfa22d307ed76d902abad3398ee3ecfb3aee4f9577118480dacb283</citedby><cites>FETCH-LOGICAL-b616t-b4db86fec2bfa22d307ed76d902abad3398ee3ecfb3aee4f9577118480dacb283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://thorax.bmj.com/content/69/5/445.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://thorax.bmj.com/content/69/5/445.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,314,777,781,882,3183,23552,27905,27906,77349,77380</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24355825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singer, Jonathan Paul</creatorcontrib><creatorcontrib>Blanc, Paul David</creatorcontrib><creatorcontrib>Dean, Y Monica</creatorcontrib><creatorcontrib>Hays, Steven</creatorcontrib><creatorcontrib>Leard, Lorriana</creatorcontrib><creatorcontrib>Kukreja, Jasleen</creatorcontrib><creatorcontrib>Golden, Jeffrey</creatorcontrib><creatorcontrib>Katz, Patricia P</creatorcontrib><title>Development and validation of a lung transplant-specific disability questionnaire</title><title>Thorax</title><addtitle>Thorax</addtitle><description>Background Lung transplant (LT) aims to extend survival and improve patient-centred outcomes (PCOs) by reducing disability and improving health-related quality of life (HRQL). Few PCO instruments have been validated in LT populations. We aimed to develop and validate a shortened version of the valued life activities (VLA) disability scale specific to LT. Methods We used data from 140 subjects participating in an ongoing cohort study of LT. Subjects completed a survey battery, including VLA items, and physical assessments before LT. To develop a shortened LT-specific VLA (LT-VLA), we iteratively deleted items from a longer 32-item VLA battery, retaining the instrument's conceptual framework, scoring and performance characteristics. We evaluated LT-VLA validity by testing correlations with a HRQL measure (Short Form-12 Physical Function (SF-12 PF) subscale), forced vital capacity % (FVC%) predicted and 6 minute walk distance (6MWD). Responsiveness was evaluated in 84 subjects who completed assessments before and after LT. Results The 15-item LT-VLA scoring closely matched the longer VLA (correlations ≥0.96) and had excellent internal consistency (Cronbach's α 0.92). The LT-VLA required only 3 min or less to administer. The LT-VLA, measured as mean difficulty in performing each of the 15 activities queried, correlated with FVC% predicted (r=−0.30), 6MWD (r=−0.38) and SF-12 PF (r=−0.47) (all p<0.01). The LT-VLA mean difficulty was responsive to change from before to after LT (63% improvement; effect size=1.60). Conclusions The LT-VLA is a short, easy to administer, valid and responsive disease-specific PCO instrument that may be useful in clinical and research applications for lung transplantation.</description><subject>Activities of daily living</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Disability</subject><subject>Disability Evaluation</subject><subject>Disabled Persons - psychology</subject><subject>Disabled Persons - statistics & numerical data</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Humans</subject><subject>Lung - physiopathology</subject><subject>Lung diseases</subject><subject>Lung Transplantation - rehabilitation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Outcome Assessment (Health Care) - methods</subject><subject>Patients</subject><subject>Quality of Life</subject><subject>Reproducibility of Results</subject><subject>Studies</subject><subject>Surveys and Questionnaires</subject><subject>Transplants & implants</subject><subject>Vital Capacity</subject><subject>Walking - physiology</subject><issn>0040-6376</issn><issn>1468-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU9rFTEUxYMo9rX6EZQBN25G8z-ZjSDVqlAoBV2HZHKnzWMmGZOZh_325vnqQ7vqJneR3znccw9Crwh-RwiT75fblO2vbRxbigmrDxdCPUEbwqVuGe3kU7TBmONWMiVP0GkpW4yxJkQ9RyeUMyE0FRt0_Ql2MKZ5grg0NvpmZ8fg7RJSbNLQ2GZc402zZBvLPNq4tGWGPgyhb3wo1oUxLHfNzxXKXhFtyPACPRvsWODl_TxDPy4-fz__2l5effl2_vGydZLIpXXcOy0H6KkbLKWeYQVeSd9hap31jHUagEE_OGYB-NAJpQjRXGNve0c1O0MfDr7z6ibwfQ2Q7WjmHCab70yywfz_E8OtuUk7w-v9BJbV4O29QU5_EpgplB7GGhPSWgwRRHKMGe8q-uYBuk1rjjWeIUoTTaujqpQ4UH1OpWQYjssQbPalmWNpZl-aOZRWda__TXJU_W2pAvgAuGn7SM_fyVyoQw</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Singer, Jonathan Paul</creator><creator>Blanc, Paul David</creator><creator>Dean, Y Monica</creator><creator>Hays, Steven</creator><creator>Leard, Lorriana</creator><creator>Kukreja, Jasleen</creator><creator>Golden, Jeffrey</creator><creator>Katz, Patricia P</creator><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140501</creationdate><title>Development and validation of a lung transplant-specific disability questionnaire</title><author>Singer, Jonathan Paul ; Blanc, Paul David ; Dean, Y Monica ; Hays, Steven ; Leard, Lorriana ; Kukreja, Jasleen ; Golden, Jeffrey ; Katz, Patricia P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b616t-b4db86fec2bfa22d307ed76d902abad3398ee3ecfb3aee4f9577118480dacb283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Activities of daily living</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Disability</topic><topic>Disability Evaluation</topic><topic>Disabled Persons - psychology</topic><topic>Disabled Persons - statistics & numerical data</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Humans</topic><topic>Lung - physiopathology</topic><topic>Lung diseases</topic><topic>Lung Transplantation - rehabilitation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Outcome Assessment (Health Care) - methods</topic><topic>Patients</topic><topic>Quality of Life</topic><topic>Reproducibility of Results</topic><topic>Studies</topic><topic>Surveys and Questionnaires</topic><topic>Transplants & implants</topic><topic>Vital Capacity</topic><topic>Walking - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singer, Jonathan Paul</creatorcontrib><creatorcontrib>Blanc, Paul David</creatorcontrib><creatorcontrib>Dean, Y Monica</creatorcontrib><creatorcontrib>Hays, Steven</creatorcontrib><creatorcontrib>Leard, Lorriana</creatorcontrib><creatorcontrib>Kukreja, Jasleen</creatorcontrib><creatorcontrib>Golden, Jeffrey</creatorcontrib><creatorcontrib>Katz, Patricia P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Thorax</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singer, Jonathan Paul</au><au>Blanc, Paul David</au><au>Dean, Y Monica</au><au>Hays, Steven</au><au>Leard, Lorriana</au><au>Kukreja, Jasleen</au><au>Golden, Jeffrey</au><au>Katz, Patricia P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development and validation of a lung transplant-specific disability questionnaire</atitle><jtitle>Thorax</jtitle><addtitle>Thorax</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>69</volume><issue>5</issue><spage>445</spage><epage>450</epage><pages>445-450</pages><issn>0040-6376</issn><eissn>1468-3296</eissn><coden>THORA7</coden><abstract>Background Lung transplant (LT) aims to extend survival and improve patient-centred outcomes (PCOs) by reducing disability and improving health-related quality of life (HRQL). Few PCO instruments have been validated in LT populations. We aimed to develop and validate a shortened version of the valued life activities (VLA) disability scale specific to LT. Methods We used data from 140 subjects participating in an ongoing cohort study of LT. Subjects completed a survey battery, including VLA items, and physical assessments before LT. To develop a shortened LT-specific VLA (LT-VLA), we iteratively deleted items from a longer 32-item VLA battery, retaining the instrument's conceptual framework, scoring and performance characteristics. We evaluated LT-VLA validity by testing correlations with a HRQL measure (Short Form-12 Physical Function (SF-12 PF) subscale), forced vital capacity % (FVC%) predicted and 6 minute walk distance (6MWD). Responsiveness was evaluated in 84 subjects who completed assessments before and after LT. Results The 15-item LT-VLA scoring closely matched the longer VLA (correlations ≥0.96) and had excellent internal consistency (Cronbach's α 0.92). The LT-VLA required only 3 min or less to administer. The LT-VLA, measured as mean difficulty in performing each of the 15 activities queried, correlated with FVC% predicted (r=−0.30), 6MWD (r=−0.38) and SF-12 PF (r=−0.47) (all p<0.01). The LT-VLA mean difficulty was responsive to change from before to after LT (63% improvement; effect size=1.60). Conclusions The LT-VLA is a short, easy to administer, valid and responsive disease-specific PCO instrument that may be useful in clinical and research applications for lung transplantation.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>24355825</pmid><doi>10.1136/thoraxjnl-2013-204557</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Activities of daily living Chronic obstructive pulmonary disease Disability Disability Evaluation Disabled Persons - psychology Disabled Persons - statistics & numerical data Female Forced Expiratory Volume Humans Lung - physiopathology Lung diseases Lung Transplantation - rehabilitation Male Middle Aged Outcome Assessment (Health Care) - methods Patients Quality of Life Reproducibility of Results Studies Surveys and Questionnaires Transplants & implants Vital Capacity Walking - physiology |
| title | Development and validation of a lung transplant-specific disability questionnaire |
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